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| Status |
Public on Jul 16, 2019 |
| Title |
COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We show that the COMPASS family histone methyltransferase co-factor ASH2L is required in NPCs proliferation and upper layer cortical projection neurons production and position. Deletion of ASH2L impairs trimethylation of H3K4 and transcriptional machinery specifically for subsets of Wnt-β-catenin signaling, disrupting their transcription and consequently inhibiting the proliferation ability of NPCs in late stages of neurogenesis.
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| Overall design |
We generated D6-Cre Ash2l conditional knockout mice.Through RNA-seq and ChIPseq of dorsal cortex from Ash2l WT and cKO mice to identify the role of Ash2l during corticogenesis
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| Contributor(s) |
Peng X, Li L |
| Citation(s) |
31315048 |
| |
| Submission date |
Oct 09, 2018 |
| Last update date |
Oct 18, 2019 |
| Contact name |
Xiaozhong Peng |
| E-mail(s) |
pengxiaozhong@pumc.edu.cn
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| Phone |
86 69156434
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| Organization name |
Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College
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| Department |
Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences
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| Lab |
Lab of Xiaozhong Peng
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| Street address |
No.5, Dongdan Santiao, Dongcheng District
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| City |
Beijing |
| ZIP/Postal code |
100005 |
| Country |
China |
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| Platforms (1) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE120988 |
COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling |
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| Relations |
| BioProject |
PRJNA495176 |
| SRA |
SRP164691 |
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