GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE120986 Query DataSets for GSE120986
Status Public on Jul 16, 2019
Title COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We show that the COMPASS family histone methyltransferase co-factor ASH2L is required in NPCs proliferation and upper layer cortical projection neurons production and position. Deletion of ASH2L impairs trimethylation of H3K4 and transcriptional machinery specifically for subsets of Wnt-β-catenin signaling, disrupting their transcription and consequently inhibiting the proliferation ability of NPCs in late stages of neurogenesis.
Overall design We generated D6-Cre Ash2l conditional knockout mice.Through RNA-seq and ChIPseq of dorsal cortex from Ash2l WT and cKO mice to identify the role of Ash2l during corticogenesis
Contributor(s) Peng X, Li L
Citation(s) 31315048
Submission date Oct 09, 2018
Last update date Oct 18, 2019
Contact name Xiaozhong Peng
Phone 86 69156434
Organization name Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College
Department Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences
Lab Lab of Xiaozhong Peng
Street address No.5, Dongdan Santiao, Dongcheng District
City Beijing
ZIP/Postal code 100005
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (12)
GSM3423423 E14.5_248_6_WT
GSM3423424 E14.5_248_2_KO
GSM3423425 E14.5_351_1_WT
This SubSeries is part of SuperSeries:
GSE120988 COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling
BioProject PRJNA495176
SRA SRP164691

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE120986_E14.5_condition.DESeq2_results_allgenes.csv.gz 761.1 Kb (ftp)(http) CSV
GSE120986_E14.5_featureCounts.txt.gz 2.1 Mb (ftp)(http) TXT
GSE120986_E16.5_condition.DESeq2_results_allgenes.csv.gz 766.3 Kb (ftp)(http) CSV
GSE120986_E16.5_featureCounts.txt.gz 2.1 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap