Dcaf11 DDB1 and CUL4 associated factor 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcaf11provided by MGI
Official Full Name: DDB1 and CUL4 associated factor 11provided by MGI
Primary source: MGI:MGI:90168
See related: Ensembl:ENSMUSG00000022214 AllianceGenome:MGI:90168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GLO14; Wdr23; Dacf11; D14Ucla1; 0710008A13Rik
Summary: Acts upstream of or within several processes, including exploration behavior; protein stabilization; and respiratory system process. Predicted to be located in nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF11 (DDB1 and CUL4 associated factor 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver adult (RPKM 65.2), kidney adult (RPKM 42.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55796557..55807522)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55559125..55570065)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Title: WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain.
Title: Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 11

Names: WD repeat domain 23; WD repeat-containing protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199009.1 → NP_001185938.1 DDB1- and CUL4-associated factor 11

See identical proteins and their annotated locations for NP_001185938.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK033540, AK150183, DV648268

Consensus CDS

CCDS27115.1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Related

ENSMUSP00000072344.5, ENSMUST00000072530.11

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_133734.3 → NP_598495.1 DDB1- and CUL4-associated factor 11

See identical proteins and their annotated locations for NP_598495.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK033540, BB845333

Consensus CDS

CCDS27115.1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Related

ENSMUSP00000113014.2, ENSMUST00000117236.8

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

NR_037572.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple splice site differences at the 5' end, compared to variant 1, which result in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK158784, BB845333

Related

ENSMUST00000150019.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

55796557..55807522

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247848.2 → XP_030103708.1 DDB1- and CUL4-associated factor 11 isoform X1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030247846.2 → XP_030103706.1 DDB1- and CUL4-associated factor 11 isoform X1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030247849.2 → XP_030103709.1 DDB1- and CUL4-associated factor 11 isoform X2

UniProtKB/TrEMBL

Q3TYA0, Q3UD98

Conserved Domains (2) summary

sd00039
Location:177 → 219

7WD40; WD40 repeat [structural motif]

cl29593
Location:136 → 467

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519081.5 → XP_006519144.1 DDB1- and CUL4-associated factor 11 isoform X1

See identical proteins and their annotated locations for XP_006519144.1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519087.5 → XP_006519150.1 DDB1- and CUL4-associated factor 11 isoform X2

See identical proteins and their annotated locations for XP_006519150.1

UniProtKB/TrEMBL

Q3TYA0, Q3UD98

Conserved Domains (2) summary

sd00039
Location:177 → 219

7WD40; WD40 repeat [structural motif]

cl29593
Location:136 → 467

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030247847.2 → XP_030103707.1 DDB1- and CUL4-associated factor 11 isoform X1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519083.5 → XP_006519146.1 DDB1- and CUL4-associated factor 11 isoform X1

See identical proteins and their annotated locations for XP_006519146.1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519088.5 → XP_006519151.1 DDB1- and CUL4-associated factor 11 isoform X2

See identical proteins and their annotated locations for XP_006519151.1

UniProtKB/TrEMBL

Q3TYA0, Q3UD98

Conserved Domains (2) summary

sd00039
Location:177 → 219

7WD40; WD40 repeat [structural motif]

cl29593
Location:136 → 467

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519085.5 → XP_006519148.1 DDB1- and CUL4-associated factor 11 isoform X1

See identical proteins and their annotated locations for XP_006519148.1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Related

ENSMUSP00000113202.2, ENSMUST00000121622.8

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519090.5 → XP_006519153.1 DDB1- and CUL4-associated factor 11 isoform X2

See identical proteins and their annotated locations for XP_006519153.1

UniProtKB/TrEMBL

Q3TYA0, Q3UD98

Conserved Domains (2) summary

sd00039
Location:177 → 219

7WD40; WD40 repeat [structural motif]

cl29593
Location:136 → 467

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519084.5 → XP_006519147.1 DDB1- and CUL4-associated factor 11 isoform X1

See identical proteins and their annotated locations for XP_006519147.1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519091.5 → XP_006519154.1 DDB1- and CUL4-associated factor 11 isoform X2

See identical proteins and their annotated locations for XP_006519154.1

UniProtKB/TrEMBL

Q3TYA0, Q3UD98

Conserved Domains (2) summary

sd00039
Location:177 → 219

7WD40; WD40 repeat [structural motif]

cl29593
Location:136 → 467

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030247851.2 → XP_030103711.1 DDB1- and CUL4-associated factor 11 isoform X3

Conserved Domains (2) summary

sd00039
Location:56 → 93

7WD40; WD40 repeat [structural motif]

cl29593
Location:55 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036158655.1 → XP_036014548.1 DDB1- and CUL4-associated factor 11 isoform X3

Conserved Domains (2) summary

sd00039
Location:56 → 93

7WD40; WD40 repeat [structural motif]

cl29593
Location:55 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036158656.1 → XP_036014549.1 DDB1- and CUL4-associated factor 11 isoform X3

Conserved Domains (2) summary

sd00039
Location:56 → 93

7WD40; WD40 repeat [structural motif]

cl29593
Location:55 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036158658.1 → XP_036014551.1 DDB1- and CUL4-associated factor 11 isoform X3

Conserved Domains (2) summary

sd00039
Location:56 → 93

7WD40; WD40 repeat [structural motif]

cl29593
Location:55 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036158657.1 → XP_036014550.1 DDB1- and CUL4-associated factor 11 isoform X3

Conserved Domains (2) summary

sd00039
Location:56 → 93

7WD40; WD40 repeat [structural motif]

cl29593
Location:55 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006519086.5 → XP_006519149.1 DDB1- and CUL4-associated factor 11 isoform X1

See identical proteins and their annotated locations for XP_006519149.1

UniProtKB/Swiss-Prot

Q3U836, Q8JZV8, Q91VU6

UniProtKB/TrEMBL

Q3UD98

Conserved Domains (2) summary

sd00039
Location:221 → 263

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 511

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030247850.2 → XP_030103710.1 DDB1- and CUL4-associated factor 11 isoform X2

UniProtKB/TrEMBL

Q3TYA0, Q3UD98

Conserved Domains (2) summary

sd00039
Location:177 → 219

7WD40; WD40 repeat [structural motif]

cl29593
Location:136 → 467

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036158659.1 → XP_036014552.1 DDB1- and CUL4-associated factor 11 isoform X3

Conserved Domains (2) summary

sd00039
Location:56 → 93

7WD40; WD40 repeat [structural motif]

cl29593
Location:55 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...