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Conserved domains on  [gi|312222692|ref|NP_001185938|]
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DDB1- and CUL4-associated factor 11 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 4.31e-38

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 4.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 259
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 260 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 340 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW-- 417
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFsp 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 418 -----------KKLKL---PGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHK 483
Cdd:COG2319  299 dgkllasgsddGTVRLwdlATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHT 372

                        330       340
                 ....*....|....*....|....*...
gi 312222692 484 ACVRDVSWHPFEEKIVSSSWDGNLRLWQ 511
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 4.31e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 4.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 259
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 260 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 340 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW-- 417
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFsp 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 418 -----------KKLKL---PGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHK 483
Cdd:COG2319  299 dgkllasgsddGTVRLwdlATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHT 372

                        330       340
                 ....*....|....*....|....*...
gi 312222692 484 ACVRDVSWHPFEEKIVSSSWDGNLRLWQ 511
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-511 3.59e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 3.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 171 YSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWsvldVAFTPDGNhFLYSSWSDyiHICNIYGE 250
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGT-YLASGSSD--KTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 251 GDTHTALDLRPDErrFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFaDISSQILFSGGDDA 330
Cdd:cd00200   81 ETGECVRTLTGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 331 ICKVWDRRTMreddpKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRrfssregmeasrlaatqqnwdyrwq 410
Cdd:cd00200  158 TIKLWDLRTG-----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 411 qvpkiawkklklpGDSSLMTYRGHgvLHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVS 490
Cdd:cd00200  208 -------------TGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268

                        330       340
                 ....*....|....*....|.
gi 312222692 491 WHPFEEKIVSSSWDGNLRLWQ 511
Cdd:cd00200  269 WSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 141-384 6.01e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 6.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 141 GLCHRGSFSlgeQSRVMSHFLPNDLsftdTYSQKAFCGI-YSKDGQIFMSACQDQTIRLYDCrygrfhkfKSI--KARDV 217
Cdd:PLN00181 458 GLCKYLSFS---KLRVKADLKQGDL----LNSSNLVCAIgFDRDGEFFATAGVNKKIKIFEC--------ESIikDGRDI 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 218 GWSVLDVAFTPDGNHFLYSSW-------SDYIHICNIYGEGDTHTALDLRPDERRfaVFSIAVSSDGREVLG-GANDGCL 289
Cdd:PLN00181 523 HYPVVELASRSKLSGICWNSYiksqvasSNFEGVVQVWDVARSQLVTEMKEHEKR--VWSIDYSSADPTLLAsGSDDGSV 600

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 290 YVFDREQNRRTLQIEShEDDVNAVAFADISSQILFSGGDDAICKVWDRRtmredDPK-PVGALAGHQDGITFIDSKgDAR 368
Cdd:PLN00181 601 KLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLR-----NPKlPLCTMIGHSKTVSYVRFV-DSS 673

                        250
                 ....*....|....*.
gi 312222692 369 YLISNSKDQTIKLWDI 384
Cdd:PLN00181 674 TLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 472-510 4.11e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 312222692   472 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
473-510 6.32e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.32e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 312222692  473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 4.31e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 4.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 259
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 260 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 340 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW-- 417
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFsp 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 418 -----------KKLKL---PGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHK 483
Cdd:COG2319  299 dgkllasgsddGTVRLwdlATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHT 372

                        330       340
                 ....*....|....*....|....*...
gi 312222692 484 ACVRDVSWHPFEEKIVSSSWDGNLRLWQ 511
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-511 3.59e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 3.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 171 YSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWsvldVAFTPDGNhFLYSSWSDyiHICNIYGE 250
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGT-YLASGSSD--KTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 251 GDTHTALDLRPDErrFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFaDISSQILFSGGDDA 330
Cdd:cd00200   81 ETGECVRTLTGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 331 ICKVWDRRTMreddpKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRrfssregmeasrlaatqqnwdyrwq 410
Cdd:cd00200  158 TIKLWDLRTG-----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 411 qvpkiawkklklpGDSSLMTYRGHgvLHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVS 490
Cdd:cd00200  208 -------------TGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268

                        330       340
                 ....*....|....*....|.
gi 312222692 491 WHPFEEKIVSSSWDGNLRLWQ 511
Cdd:cd00200  269 WSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 220-513 2.34e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 2.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 220 SVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTaldlrPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRR 299
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-----LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 300 TLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTI 379
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET-----GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 380 KLWDIRrfssregmeasrlaatqqnwdyrwqqvpkiawkklklpGDSSLMTYRGH--GVLHtlirCRFSPahsTGQQFIy 457
Cdd:cd00200  160 KLWDLR--------------------------------------TGKCVATLTGHtgEVNS----VAFSP---DGEKLL- 193

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 312222692 458 SGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 513
Cdd:cd00200  194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
180-385 2.27e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 2.27e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 180 YSKDGQIFMSACQDQTIRLYDCRYGRFhkFKSIKARdvGWSVLDVAFTPDGNHFLYSSWSDYIHICNIygegDTHTALDL 259
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKL--LRTLTGH--SGSVRSVAFSPDGRLLASGSADGTVRLWDL----ATGELLRT 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 260 RPDERRfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  284 LTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222692 340 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIR 385
Cdd:COG2319  362 -----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
255-510 4.48e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 4.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 255 TALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKV 334
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 335 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS--------RLAA 400
Cdd:COG2319  147 WDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlatgklLRTLTGHTGAVRSvafspdgkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 401 TQQN-----WDyrwqqvpkiawkklkLPGDSSLMTYRGHGVLHTLIrcRFSPahstGQQFIYSGCSTGKVVVYDLLSGHI 475
Cdd:COG2319  222 GSADgtvrlWD---------------LATGKLLRTLTGHSGSVRSV--AFSP----DGRLLASGSADGTVRLWDLATGEL 280

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 312222692 476 VKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:COG2319  281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 302-534 6.25e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 6.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 302 QIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTMReddpkPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKL 381
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 382 WDIRrfssregmeasrlaatqqnwdyrwqqvpkiawkklklpGDSSLMTYRGH--GVLHtlirCRFSPAHstgqQFIYSG 459
Cdd:cd00200   78 WDLE--------------------------------------TGECVRTLTGHtsYVSS----VAFSPDG----RILSSS 111

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312222692 460 CSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQD-DMPESDMNRVCSSG 534
Cdd:cd00200  112 SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSP 187
WD40 COG2319
WD40 repeat [General function prediction only];
180-339 1.41e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKfksIKARDVGWsVLDVAFTPDGNHFLYSSWSDYIHICNIygegDTHTALDL 259
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLR---TLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDL----ATGKLLRT 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 260 RPDERRfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  326 LTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
255-510 2.07e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 255 TALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAIcKV 334
Cdd:COG2319   26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 335 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRfssregmeasrlaatqqnwdyrwqqvpk 414
Cdd:COG2319  105 WDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT---------------------------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 415 iaWKKLKlpgdsslmTYRGHGvlHTLIRCRFSPahsTGQqFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPF 494
Cdd:COG2319  152 --GKLLR--------TLTGHS--GAVTSVAFSP---DGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                        250
                 ....*....|....*.
gi 312222692 495 EEKIVSSSWDGNLRLW 510
Cdd:COG2319  216 GKLLASGSADGTVRLW 231
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 141-384 6.01e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 6.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 141 GLCHRGSFSlgeQSRVMSHFLPNDLsftdTYSQKAFCGI-YSKDGQIFMSACQDQTIRLYDCrygrfhkfKSI--KARDV 217
Cdd:PLN00181 458 GLCKYLSFS---KLRVKADLKQGDL----LNSSNLVCAIgFDRDGEFFATAGVNKKIKIFEC--------ESIikDGRDI 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 218 GWSVLDVAFTPDGNHFLYSSW-------SDYIHICNIYGEGDTHTALDLRPDERRfaVFSIAVSSDGREVLG-GANDGCL 289
Cdd:PLN00181 523 HYPVVELASRSKLSGICWNSYiksqvasSNFEGVVQVWDVARSQLVTEMKEHEKR--VWSIDYSSADPTLLAsGSDDGSV 600

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 290 YVFDREQNRRTLQIEShEDDVNAVAFADISSQILFSGGDDAICKVWDRRtmredDPK-PVGALAGHQDGITFIDSKgDAR 368
Cdd:PLN00181 601 KLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLR-----NPKlPLCTMIGHSKTVSYVRFV-DSS 673

                        250
                 ....*....|....*.
gi 312222692 369 YLISNSKDQTIKLWDI 384
Cdd:PLN00181 674 TLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 472-510 4.11e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 312222692   472 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
473-510 6.32e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.32e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 312222692  473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
346-383 4.42e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 312222692  346 KPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 244-384 1.26e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 244 ICNIYGEGDTHTALDLRPDERRFAVFSIAVSSD----GREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADIS 319
Cdd:PTZ00420   7 IKNLYPDPSNNLFDDLRICSRVIDSCGIACSSGfvavPWEVEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCF 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312222692 320 SQILFSGGDDAICKVWDRRTMRED-----DPKPVgaLAGHQDGITFIDSKGDARYLISNSK-DQTIKLWDI 384
Cdd:PTZ00420  87 SEILASGSEDLTIRVWEIPHNDESvkeikDPQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-383 1.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.64e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312222692   344 DPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 303-336 7.61e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 7.61e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 312222692   303 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 336
Cdd:smart00320   8 LKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
303-336 1.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 312222692  303 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 336
Cdd:pfam00400   7 LEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 301-403 5.95e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 5.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222692 301 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIK 380
Cdd:PTZ00421 119 VHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-----GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLN 193

                         90       100
                 ....*....|....*....|...
gi 312222692 381 LWDIRRFSSREGMEASRLAATQQ 403
Cdd:PTZ00421 194 IIDPRDGTIVSSVEAHASAKSQR 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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