NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907101789|ref|XP_036014548|]
View 

DDB1- and CUL4-associated factor 11 isoform X3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
55-299 1.34e-31

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  55 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPK 134
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-----GK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 135 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW--------- 205
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFspdgkllas 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 206 ----KKLKL---PGDSSLMTYRGHGVLHTLIRcrFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVS 278
Cdd:COG2319   306 gsddGTVRLwdlATGKLLRTLTGHTGAVRSVA--FSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379

                         250       260
                  ....*....|....*....|.
gi 1907101789 279 WHPFEEKIVSSSWDGNLRLWQ 299
Cdd:COG2319   380 FSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
55-299 1.34e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  55 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPK 134
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-----GK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 135 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW--------- 205
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFspdgkllas 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 206 ----KKLKL---PGDSSLMTYRGHGVLHTLIRcrFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVS 278
Cdd:COG2319   306 gsddGTVRLwdlATGKLLRTLTGHTGAVRSVA--FSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379

                         250       260
                  ....*....|....*....|.
gi 1907101789 279 WHPFEEKIVSSSWDGNLRLWQ 299
Cdd:COG2319   380 FSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-299 3.52e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 3.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  55 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPK 134
Cdd:cd00200    53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET-----GK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 135 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSR---EGMEasrlaatqqnwdyrwQQVPKIAW------ 205
Cdd:cd00200   127 CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVatlTGHT---------------GEVNSVAFspdgek 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 206 ----------KKLKLPGDSSLMTYRGHgvLHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVR 275
Cdd:cd00200   192 llssssdgtiKLWDLSTGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                         250       260
                  ....*....|....*....|....
gi 1907101789 276 DVSWHPFEEKIVSSSWDGNLRLWQ 299
Cdd:cd00200   266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 260-298 3.97e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 3.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907101789  260 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 298
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
261-298 5.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907101789 261 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 298
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 67-172 7.91e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 7.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  67 EVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMRED-----DPKPVgaLAG 141
Cdd:PTZ00420   46 EVEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESvkeikDPQCI--LKG 123

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907101789 142 HQDGITFIDSKGDARYLISNSK-DQTIKLWDI 172
Cdd:PTZ00420  124 HKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI 155
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
55-299 1.34e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  55 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPK 134
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-----GK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 135 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW--------- 205
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFspdgkllas 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 206 ----KKLKL---PGDSSLMTYRGHGVLHTLIRcrFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVS 278
Cdd:COG2319   306 gsddGTVRLwdlATGKLLRTLTGHTGAVRSVA--FSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379

                         250       260
                  ....*....|....*....|.
gi 1907101789 279 WHPFEEKIVSSSWDGNLRLWQ 299
Cdd:COG2319   380 FSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-299 3.52e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 3.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  55 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPK 134
Cdd:cd00200    53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET-----GK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 135 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSR---EGMEasrlaatqqnwdyrwQQVPKIAW------ 205
Cdd:cd00200   127 CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVatlTGHT---------------GEVNSVAFspdgek 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 206 ----------KKLKLPGDSSLMTYRGHgvLHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVR 275
Cdd:cd00200   192 llssssdgtiKLWDLSTGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                         250       260
                  ....*....|....*....|....
gi 1907101789 276 DVSWHPFEEKIVSSSWDGNLRLWQ 299
Cdd:cd00200   266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
55-298 7.20e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 7.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  55 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPK 134
Cdd:COG2319   122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-----GK 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 135 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRfssreGMEASRLAATQQnwdyrwqQVPKIAW--------- 205
Cdd:COG2319   196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-----GKLLRTLTGHSG-------SVRSVAFspdgrllas 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 206 ----KKLKL---PGDSSLMTYRGHGvlHTLIRCRFSPahsTGQQFIySGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVS 278
Cdd:COG2319   264 gsadGTVRLwdlATGELLRTLTGHS--GGVNSVAFSP---DGKLLA-SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                         250       260
                  ....*....|....*....|
gi 1907101789 279 WHPFEEKIVSSSWDGNLRLW 298
Cdd:COG2319   338 FSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-301 7.68e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.12  E-value: 7.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  56 VFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQiLFSGGDDAICKVWDRRTmreddPKP 135
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-----GEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 136 VGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSregmeasrlaatqqnwdyrwqqvpkiawkklklpgdss 215
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-------------------------------------- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 216 LMTYRGH--GVLHtlirCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDG 293
Cdd:cd00200   128 LTTLRGHtdWVNS----VAFSP----DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199


                  ....*...
gi 1907101789 294 NLRLWQYR 301
Cdd:cd00200   200 TIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
43-298 1.69e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 1.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  43 RALPILPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKV 122
Cdd:COG2319    68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 123 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS--------RLAA 188
Cdd:COG2319   147 WDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlatgklLRTLTGHTGAVRSvafspdgkLLAS 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 189 TQQN-----WDyrwqqvpkiawkklkLPGDSSLMTYRGHGVLHTLIrcRFSPahstGQQFIYSGCSTGKVVVYDLLSGHI 263
Cdd:COG2319   222 GSADgtvrlWD---------------LATGKLLRTLTGHSGSVRSV--AFSP----DGRLLASGSADGTVRLWDLATGEL 280

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1907101789 264 VKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 298
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-322 3.70e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 3.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  90 QIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTMReddpkPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKL 169
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 170 WDIRrfssregmeasrlaatqqnwdyrwqqvpkiawkklklpGDSSLMTYRGHgvLHTLIRCRFSPAHstgqQFIYSGCS 249
Cdd:cd00200    78 WDLE--------------------------------------TGECVRTLTGH--TSYVSSVAFSPDG----RILSSSSR 113

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907101789 250 TGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQD-DMPESDMNRVCSSG 322
Cdd:cd00200   114 DKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSP 187
WD40 COG2319
WD40 repeat [General function prediction only];
42-298 1.85e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 1.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  42 LRALPILPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAIcK 121
Cdd:COG2319    25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-R 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 122 VWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRfssregmeasrlaatqqnwdyrwqqvp 201
Cdd:COG2319   104 LWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--------------------------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 202 kiaWKKLKlpgdsslmTYRGHGvlHTLIRCRFSPahsTGQqFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHP 281
Cdd:COG2319   152 ---GKLLR--------TLTGHS--GAVTSVAFSP---DGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 214

                         250
                  ....*....|....*..
gi 1907101789 282 FEEKIVSSSWDGNLRLW 298
Cdd:COG2319   215 DGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
55-173 8.17e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 8.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  55 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPK 134
Cdd:COG2319   290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT-----GE 363

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907101789 135 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIR 173
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
55-127 1.26e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.26e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907101789  55 AVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 127
Cdd:COG2319   332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 260-298 3.97e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 3.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907101789  260 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 298
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
153-298 1.86e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 153 GDARYLISNSKDQTIKLWDIRRFSSREGMEASRLAATQQNWDYRWQQVPKIAWKKLKLPGDSSLMTYRGHGVLHTLIRCR 232
Cdd:COG2319     6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907101789 233 FSPAHstgqQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 298
Cdd:COG2319    86 FSPDG----RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
WD40 pfam00400
WD domain, G-beta repeat;
261-298 5.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907101789 261 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 298
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
134-171 3.76e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.76e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907101789 134 KPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 171
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 67-172 7.91e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 7.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  67 EVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMRED-----DPKPVgaLAG 141
Cdd:PTZ00420   46 EVEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESvkeikDPQCI--LKG 123

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907101789 142 HQDGITFIDSKGDARYLISNSK-DQTIKLWDI 172
Cdd:PTZ00420  124 HKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI 155
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 46-172 1.18e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  46 PILPDERRFAVFSIAVSSDGREVLGGAN-DGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVW- 123
Cdd:PLN00181  525 PVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWs 604

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789 124 ----------------------------------DRRTMRED--DPK-PVGALAGHQDGITFIDSKgDARYLISNSKDQT 166
Cdd:PLN00181  605 inqgvsigtiktkaniccvqfpsesgrslafgsaDHKVYYYDlrNPKlPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNT 683


                  ....*.
gi 1907101789 167 IKLWDI 172
Cdd:PLN00181  684 LKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 132-171 1.52e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907101789  132 DPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 171
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-124 7.00e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 7.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907101789   91 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 124
Cdd:smart00320   8 LKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
91-124 1.10e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907101789  91 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 124
Cdd:pfam00400   7 LEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 89-191 3.56e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907101789  89 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIK 168
Cdd:PTZ00421  119 VHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-----GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLN 193

                          90       100
                  ....*....|....*....|...
gi 1907101789 169 LWDIRRFSSREGMEASRLAATQQ 191
Cdd:PTZ00421  194 IIDPRDGTIVSSVEAHASAKSQR 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH