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Conserved domains on  [gi|568987836|ref|XP_006519151|]
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DDB1- and CUL4-associated factor 11 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
136-467 4.92e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 4.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 136 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 215
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 216 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 295
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 296 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW-- 373
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFsp 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 374 -----------KKLKL---PGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHK 439
Cdd:COG2319  299 dgkllasgsddGTVRLwdlATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHT 372

                        330       340
                 ....*....|....*....|....*...
gi 568987836 440 ACVRDVSWHPFEEKIVSSSWDGNLRLWQ 467
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
136-467 4.92e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 4.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 136 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 215
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 216 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 295
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 296 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW-- 373
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFsp 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 374 -----------KKLKL---PGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHK 439
Cdd:COG2319  299 dgkllasgsddGTVRLwdlATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHT 372

                        330       340
                 ....*....|....*....|....*...
gi 568987836 440 ACVRDVSWHPFEEKIVSSSWDGNLRLWQ 467
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 136-467 4.63e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 4.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 136 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWsvldVAFTPDGNhFLYSSWSDyiHICNIYGEGDTHTALDL 215
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGT-YLASGSSD--KTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 216 RPDErrFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFaDISSQILFSGGDDAICKVWDRRT 295
Cdd:cd00200   90 TGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 296 MreddpKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRrfssregmeasrlaatqqnwdyrwqqvpkiawkk 375
Cdd:cd00200  167 G-----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 376 lklpGDSSLMTYRGHgvLHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIV 455
Cdd:cd00200  208 ----TGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        330
                 ....*....|..
gi 568987836 456 SSSWDGNLRLWQ 467
Cdd:cd00200  278 SGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-340 5.08e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 5.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836  97 GLCHRGSFSlgeQSRVMSHFLPNDLsftdTYSQKAFCGI-YSKDGQIFMSACQDQTIRLYDCrygrfhkfKSI--KARDV 173
Cdd:PLN00181 458 GLCKYLSFS---KLRVKADLKQGDL----LNSSNLVCAIgFDRDGEFFATAGVNKKIKIFEC--------ESIikDGRDI 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 174 GWSVLDVAFTPDGNHFLYSSW-------SDYIHICNIYGEGDTHTALDLRPDERRfaVFSIAVSSDGREVLG-GANDGCL 245
Cdd:PLN00181 523 HYPVVELASRSKLSGICWNSYiksqvasSNFEGVVQVWDVARSQLVTEMKEHEKR--VWSIDYSSADPTLLAsGSDDGSV 600

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 246 YVFDREQNRRTLQIEShEDDVNAVAFADISSQILFSGGDDAICKVWDRRtmredDPK-PVGALAGHQDGITFIDSKgDAR 324
Cdd:PLN00181 601 KLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLR-----NPKlPLCTMIGHSKTVSYVRFV-DSS 673

                        250
                 ....*....|....*.
gi 568987836 325 YLISNSKDQTIKLWDI 340
Cdd:PLN00181 674 TLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 428-466 5.08e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 5.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568987836   428 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 466
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
429-466 7.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568987836  429 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 466
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
136-467 4.92e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 4.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 136 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 215
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 216 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 295
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 296 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIrrfssrEGMEASRLAATQQNWdyrwqqVPKIAW-- 373
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG------VNSVAFsp 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 374 -----------KKLKL---PGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHK 439
Cdd:COG2319  299 dgkllasgsddGTVRLwdlATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHT 372

                        330       340
                 ....*....|....*....|....*...
gi 568987836 440 ACVRDVSWHPFEEKIVSSSWDGNLRLWQ 467
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 136-467 4.63e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 4.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 136 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWsvldVAFTPDGNhFLYSSWSDyiHICNIYGEGDTHTALDL 215
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGT-YLASGSSD--KTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 216 RPDErrFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFaDISSQILFSGGDDAICKVWDRRT 295
Cdd:cd00200   90 TGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 296 MreddpKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRrfssregmeasrlaatqqnwdyrwqqvpkiawkk 375
Cdd:cd00200  167 G-----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 376 lklpGDSSLMTYRGHgvLHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIV 455
Cdd:cd00200  208 ----TGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        330
                 ....*....|..
gi 568987836 456 SSSWDGNLRLWQ 467
Cdd:cd00200  278 SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-469 3.40e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 3.40e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 176 SVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTaldlrPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRR 255
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-----LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 256 TLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTI 335
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET-----GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 336 KLWDIRrfssregmeasrlaatqqnwdyrwqqvpkiawkklklpGDSSLMTYRGH--GVLHtlirCRFSPahsTGQQFIy 413
Cdd:cd00200  160 KLWDLR--------------------------------------TGKCVATLTGHtgEVNS----VAFSP---DGEKLL- 193

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568987836 414 SGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 469
Cdd:cd00200  194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
136-341 5.33e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 5.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 136 YSKDGQIFMSACQDQTIRLYDCRYGRFhkFKSIKARdvGWSVLDVAFTPDGNHFLYSSWSDYIHICNIygegDTHTALDL 215
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKL--LRTLTGH--SGSVRSVAFSPDGRLLASGSADGTVRLWDL----ATGELLRT 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 216 RPDERRfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 295
Cdd:COG2319  284 LTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568987836 296 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIR 341
Cdd:COG2319  362 -----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
211-466 9.83e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 9.83e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 211 TALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKV 290
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 291 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS--------RLAA 356
Cdd:COG2319  147 WDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlatgklLRTLTGHTGAVRSvafspdgkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 357 TQQN-----WDyrwqqvpkiawkklkLPGDSSLMTYRGHGVLHTLIrcRFSPahstGQQFIYSGCSTGKVVVYDLLSGHI 431
Cdd:COG2319  222 GSADgtvrlWD---------------LATGKLLRTLTGHSGSVRSV--AFSP----DGRLLASGSADGTVRLWDLATGEL 280

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568987836 432 VKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 466
Cdd:COG2319  281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-339 1.09e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 1.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 132 FCGIYSKDGQIFMSACQDQTIRLYDCRYGRFHK-FKSIKArdvgwSVLDVAFTPDgNHFLYSSWSD-YIHICNIYGEGDT 209
Cdd:cd00200   97 SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTtLRGHTD-----WVNSVAFSPD-GTFVASSSQDgTIKLWDLRTGKCV 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 210 HTALDLRPDerrfaVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICK 289
Cdd:cd00200  171 ATLTGHTGE-----VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIR 244

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568987836 290 VWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 339
Cdd:cd00200  245 VWDLRT-----GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-341 6.86e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 6.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 135 IYSKDGQIFMSACQDQTIRLYD----CRYGRFHKFKSikardvgwSVLDVAFTPDGnHFLYSSWSDY-IHICNIyGEGDT 209
Cdd:cd00200   58 AASADGTYLASGSSDKTIRLWDletgECVRTLTGHTS--------YVSSVAFSPDG-RILSSSSRDKtIKVWDV-ETGKC 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 210 HTALDLRPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAIcK 289
Cdd:cd00200  128 LTTLRGHTD----WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI-K 202

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568987836 290 VWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIR 341
Cdd:cd00200  203 LWDLST-----GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 258-490 8.89e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 8.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 258 QIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTMReddpkPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKL 337
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 338 WDIRrfssregmeasrlaatqqnwdyrwqqvpkiawkklklpGDSSLMTYRGH--GVLHtlirCRFSPAHstgqQFIYSG 415
Cdd:cd00200   78 WDLE--------------------------------------TGECVRTLTGHtsYVSS----VAFSPDG----RILSSS 111

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568987836 416 CSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQD-DMPESDMNRVCSSG 490
Cdd:cd00200  112 SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSP 187
WD40 COG2319
WD40 repeat [General function prediction only];
136-295 5.42e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 5.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 136 YSKDGQIFMSACQDQTIRLYDCRYGRFHKfksIKARDVGWsVLDVAFTPDGNHFLYSSWSDYIHICNIygegDTHTALDL 215
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLR---TLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDL----ATGKLLRT 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 216 RPDERRfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 295
Cdd:COG2319  326 LTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
211-466 6.69e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 6.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 211 TALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAIcKV 290
Cdd:COG2319   26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 291 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRfssregmeasrlaatqqnwdyrwqqvpk 370
Cdd:COG2319  105 WDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT---------------------------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 371 iaWKKLKlpgdsslmTYRGHGvlHTLIRCRFSPahsTGQqFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPF 450
Cdd:COG2319  152 --GKLLR--------TLTGHS--GAVTSVAFSP---DGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                        250
                 ....*....|....*.
gi 568987836 451 EEKIVSSSWDGNLRLW 466
Cdd:COG2319  216 GKLLASGSADGTVRLW 231
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-340 5.08e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 5.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836  97 GLCHRGSFSlgeQSRVMSHFLPNDLsftdTYSQKAFCGI-YSKDGQIFMSACQDQTIRLYDCrygrfhkfKSI--KARDV 173
Cdd:PLN00181 458 GLCKYLSFS---KLRVKADLKQGDL----LNSSNLVCAIgFDRDGEFFATAGVNKKIKIFEC--------ESIikDGRDI 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 174 GWSVLDVAFTPDGNHFLYSSW-------SDYIHICNIYGEGDTHTALDLRPDERRfaVFSIAVSSDGREVLG-GANDGCL 245
Cdd:PLN00181 523 HYPVVELASRSKLSGICWNSYiksqvasSNFEGVVQVWDVARSQLVTEMKEHEKR--VWSIDYSSADPTLLAsGSDDGSV 600

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 246 YVFDREQNRRTLQIEShEDDVNAVAFADISSQILFSGGDDAICKVWDRRtmredDPK-PVGALAGHQDGITFIDSKgDAR 324
Cdd:PLN00181 601 KLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLR-----NPKlPLCTMIGHSKTVSYVRFV-DSS 673

                        250
                 ....*....|....*.
gi 568987836 325 YLISNSKDQTIKLWDI 340
Cdd:PLN00181 674 TLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 428-466 5.08e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 5.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568987836   428 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 466
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
429-466 7.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568987836  429 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 466
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
302-339 5.09e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568987836  302 KPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 339
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 200-340 1.19e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 200 ICNIYGEGDTHTALDLRPDERRFAVFSIAVSSD----GREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADIS 275
Cdd:PTZ00420   7 IKNLYPDPSNNLFDDLRICSRVIDSCGIACSSGfvavPWEVEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCF 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568987836 276 SQILFSGGDDAICKVWDRRTMRED-----DPKPVgaLAGHQDGITFIDSKGDARYLISNSK-DQTIKLWDI 340
Cdd:PTZ00420  87 SEILASGSEDLTIRVWEIPHNDESvkeikDPQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 300-339 1.97e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568987836   300 DPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 339
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 259-292 8.87e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568987836   259 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 292
Cdd:smart00320   8 LKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
259-292 1.44e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568987836  259 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 292
Cdd:pfam00400   7 LEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 257-359 5.23e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 5.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987836 257 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIK 336
Cdd:PTZ00421 119 VHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-----GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLN 193

                         90       100
                 ....*....|....*....|...
gi 568987836 337 LWDIRRFSSREGMEASRLAATQQ 359
Cdd:PTZ00421 194 IIDPRDGTIVSSVEAHASAKSQR 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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