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GEO DataSets

Functional Genomics Studies

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Select item 2002107661.

A ribosomal protein homolog modulates gene expression and virulence in a bacterial pathogen

(Submitter supplied) To assess which F. tularensis LVS transcripts are impacted by loss of bS21-2, we generated cells lacking the gene encoding bS21-2 (LVS ∆rpsU2). We then grew wild-type cells containing an empty vector (LVS pF), cells lacking bS21-2 with empty vector (LVS ∆rpsU2 pF), and cells lacking the native bS21-2 but ectopically expressing bS21-2 from a plasmid (LVS ∆rpsU2 pF-rpsU2-V). We isolated RNA from mid-log phase cells and analyzed by RNA-Seq.

Organism:: Francisella tularensis subsp. holarctica LVS

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32555
7 Samples

Download data: TXT

Series

Accession:: GSE210766

ID:: 200210766

PubMed Full text in PMC Similar studies

Select item 2001830012.

An AraC/XylS Family Transcriptional Regulator Modulates the Oxidative Stress Response of Francisella tularensis

(Submitter supplied) Francisella tularensis is a Gram-negative bacterium that causes a fatal human disease known as tularemia. The Centers for Disease Control have classified F. tularensis as Category A Tier-1 Select Agent. The virulence mechanisms of Francisella are not entirely understood. Francisella possesses very few transcription regulators, and most of these regulate the expression of genes involved in intracellular survival and virulence. more...

Organism:: Francisella tularensis subsp. holarctica LVS

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23586
12 Samples

Download data: XLS

Series

Accession:: GSE183001

ID:: 200183001

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001386583.

Comprehensive transposon insertion sequencing screen in Francisella tularensis LVS

(Submitter supplied) We used transposon insertion sequencing (Tn-Seq) to identify the genes that are required for in vitro growth and intramacrophage growth of the live vaccine strain of F. tularensis (LVS).

Organism:: Francisella tularensis subsp. holarctica LVS

Type:: Other

Platform:: GPL27588
5 Samples

Download data: WIG

Series

Accession:: GSE138658

ID:: 200138658

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001000694.

AR-13, a celecoxib derivative, directly kills Francisella in vitro and aids clearance and mouse survival in vivo

(Submitter supplied) The goal of this study is to compare transcriptomics between wild type LVS vs AR-13 isogenic resistant mutant

Organism:: Francisella tularensis subsp. holarctica LVS

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23586
10 Samples

Download data: XLSX

Series

Accession:: GSE100069

ID:: 200100069

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000684785.

Expression data from multiple strains of Francisella

(Submitter supplied) Comparison of expression profiles of strains of Francisella to identify virulence factors We used custom microarrays to detail the global gene expression of four strains of Francisella (Schu4, LVS, OR960246, U112) and identified distinct classes of differentially expressed genes during this process.

Organism:: Francisella; Francisella tularensis subsp. novicida U112; Francisella tularensis subsp. tularensis SCHU S4; Francisella tularensis subsp. holarctica LVS; Francisella tularensis subsp. holarctica OR96246

Type:: Expression profiling by array

Platform:: GPL20119
12 Samples

Download data: CEL

Series

Accession:: GSE68478

ID:: 200068478

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000437316.

Gene Expression of F. tularensis LVS in hepatocytic cell line FL83B vs LVS cultured in MH broth

(Submitter supplied) Transcriptional profiling of LVS grown in hepatocytic cell line FL83B was compared to that of LVS cultued in MH broth to discover genes important for intracellular growth.