GEO DataSets

Analysis of TK6 lymphoblastoid cells treated with 0.1 uM sodium arsenite for 24 hours. Results provide insight into the molecular impact resulting from exposure to an environmentally relevant dose of arsenic.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6244

Series:

GSE20320

4 Samples

Download data: CEL

(Submitter supplied) We are investigating the response of human lymphoblastoid cells to low-dose exposure of environmental metals We used microarrays to detail the global programme of gene expression upon response to low-dose metals Keywords: dose

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4915 GDS4916

Platform:

GPL6244

8 Samples

Download data: CEL

Analysis of TK6 lymphoblastoid cells treated with 0.1 uM cadmium chloride for 24 hours. Results provide insight into the molecular impact resulting from exposure to an environmentally relevant dose of cadmium.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6244

Series:

GSE20320

4 Samples

Download data: CEL

(Submitter supplied) From the result of comparative the gene expression analyses of human hepatoma cell line, HepG2 following exposures of three heavy metals; arsenic, cadmium and nickel and three carcinogens; N-dimethylnitrosoamine (DMN), 12-O-tetradecanoylphorbol-13-acetate (TPA) and tetrachloroethylene (TCE), 31-55% of the genes altered by As, Cd and Ni exposure were overlapped with those by three model carcinogen exposures in our experiments. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

33 Samples

Download data: CEL

(Submitter supplied) We used microarrays to explore the global affect on gene expression in C. elegans after exposure to arsenic

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

9 Samples

Download data: CEL, CHP

(Submitter supplied) "Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins." Joseph.R.Shaw, John.K.Colbourne, Jennifer.C.Davey, Stephen.P.Glaholt, Thomas.H.Hampton, Celia.Y.Chen, Carol.L.Folt, Joshua.W.Hamilton (BMC Genomics 2007). Genomic research tools such as microarrays are proving to be important resources to study the complex regulation of genes that respond to environmental perturbations. more...

Organism:

Daphnia pulex

Type:

Expression profiling by array

Platform:

GPL6195

3 Samples

Download data: GPR, TXT

(Submitter supplied) In this study, we performed microarray-based expression profiling on liver of zebrafish exposed to 60 mg/L (192?M) arsenic [As(V)] for 8-96 h, to identify global transcriptional programs and biological networks involved in arsenic-induced adaptive responses in vivo. We identified temporal differentially-expressed gene sets which we have grouped into early, late and all-time arsenic-responsive gene sets. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS2249

Platform:

GPL2715

24 Samples

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Analysis of livers of animals at various time points up to 96 hours following exposure to 15 ppm arsenic. Arsenic is an environmental toxicant and carcinogen. Results provide insight into the molecular mechanisms underlying the toxicity and carcinogenicity of arsenic.

Organism:

Danio rerio

Type:

Expression profiling by array, log2 ratio, 2 agent, 4 time sets

Platform:

GPL2715

Series:

GSE3048

24 Samples

Download data

(Submitter supplied) Many heavy metals, including nickel (Ni), cadmium (Cd), and chromium (Cr) are toxic industrial chemicals with an exposure risk in both occupational and environmental settings that may cause harmful outcomes. While these substances are known to produce adverse health effects leading to disease or health problems, the detailed mechanisms remain unclear. To elucidate the processes involved in the of toxicity of nickel, cadmium, and chromium at the molecular level and to perform a comparative analysis, H4-II-E-C3 rat liver-derived cell lines were treated with soluble salts of each metal using concentrations derived from viability assays, and gene expression patterns were determined with DNA microarrays. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3928

Platform:

GPL1355

44 Samples

Download data: CEL

Analysis of H4-II-E-C3 liver-derived cells exposed to toxic heavy metals: nickel II chloride (NiCl2), cadmium chloride (CdCl2), or sodium dichromate (Na2Cr2O7), at various concentrations (based on viability assays). Results provide insight into molecular mechanisms underlying Ni, Cd and Cr toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 4 agent, 10 dose sets

Platform:

GPL1355

Series:

GSE31503

44 Samples

Download data: CEL

(Submitter supplied) BACKGROUND: Cadmium is implicated in prostate carcinogenesis, but its oncogenic action remains unclear. OBJECTIVES: In this study we aimed to decipher changes in cell growth and the transcriptome in an immortalized human normal prostate epithelial cell line (NPrEC) following exposure to low-dose Cd. METHODS: Synchronized NPrEC cells were exposed to different doses of Cd and assayed for cell viability and cell-cycle progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3354

Platform:

GPL570

19 Samples

Download data: CEL

Analysis of immortalized normal prostate epithelial cell line NPrEC exposed to non-cytotoxic levels of cadmium (2.5uM CdCl2) for up to 32hrs. Cadmium is implicated in prostate carcinogenesis. Results provide insight into mechanisms underlying the initiation of carcinogenesis by Cd in the prostate.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 5 time sets

Platform:

GPL570

Series:

GSE9951

19 Samples

Download data: CEL

(Submitter supplied) Arsenic is a carcinogenic metalloid element found naturally in the environment; however human activities such as mining and pesticide use have led to increased concentrations in some areas. Silurana tropicalis eggs were exposed to sublethal concentrations of sodium arsenate (0, 0.5 and 1 ppm) for 3 days during embryogenesis. Four pooled of 10 larvae were sampled per treatment and analyzed for gene expression changes using a microarray approach.

Organism:

Xenopus tropicalis

Type:

Expression profiling by array

Platform:

GPL15626

16 Samples

Download data: TXT

(Submitter supplied) Diabetes is a metabolic disorder characterized by fasting hyperglycemia and impaired glucose tolerance. Laboratory and population studies have shown that inorganic arsenic (iAs) can impair these pathways. Other metals including cadmium (Cd) and manganese (Mn) have also been linked to diabetes phenotypes. MicroRNAs, short non-coding RNAs that regulate gene expression, have emerged as potential drivers of metabolic dysfunction. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL18694 GPL22396

21 Samples

Download data: CSV

(Submitter supplied) Mesorhizobium metallidurans STM 2683 and Mesorhizobium sp. strain STM 4661 were isolated from nodules of the metallicolous legume Anthyllis vulneraria from distant mining spoils. They tolerate unusually high zinc and cadmium concentrations as compared to other mesorhizobia. This work aims to study the gene expression profiles associated with zinc or cadmium exposure and to identify genes involved in metal tolerance in these two metallicolous Mesorhizobium strains of interest for mine phytostabilization purposes.

Organism:

Mesorhizobium metallidurans STM 2683; Mesorhizobium sp. STM 4661

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16949 GPL16973

6 Samples

Download data: TXT

(Submitter supplied) Arsenic contamination of drinking water occurs globally and is associated with numerous diseases including skin, lung, and bladder cancers, and cardiovascular disease. The mechanisms behind arsenic's effects remain unclear, but recent research indicates that aresnic acts along sex-specific lines and may be an endocrine disruptor. The objective of this study was to evaluate the nature of gene expression chagnes among males and females exposed to arsenic contaminated water in Bangladesh at high and low dose exposures.The median wAs concentration for the low exposure group was 103 µg/L for males and 117 µg/L for females (range 50–200 µg/L). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16522

29 Samples

Download data: CEL

(Submitter supplied) Cells respond to changes in environment by shifting their gene expression profile to deal with the new conditions. The cellular response to changes in metal homeostasis is an important example of this. Transition metals such as iron, zinc, and copper are essential micronutrients but other metals such as cadmium are simply toxic. The cell must maintain metal concentrations in a window that supports efficient metabolic function but must also protect against the damaging effects of high concentrations of these metals. more...

Organism:

Drosophila melanogaster

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL6629

3 Samples

Download data: BAR, CEL

(Submitter supplied) The parent S. cerevisiae strain, BY4741, and specific gene deletions of the parent S.cerevisiae strain BY4741 were treated with 100uM NaAsO2 (AsIII) for 2h and compared to the untreated counterpart (yap1Δ vs. yap1Δ 2h 100uM AsIII, cad1Δ vs. cad1Δ 2h 100uMAsIII, rpn4Δ vs. rpn4Δ 2h 100uM AsIII, arr1Δ vs. arr1Δ 2h 100uM AsIII, parent vs. parent with 2h 100uM AsIII). The untreated specific deletion strain was also compared to the untreated parent strain in order to identify differential expression of genes due to the knockout alone. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platforms:

GPL884 GPL1474

40 Samples

Download data

(Submitter supplied) Transcriptional profiling of arsenic-induced toxicity and tolerance in Arabidopsis plants of different ecotypes Arsenic (As) is a toxic metalloid found ubiquitously in the environment and has widely been known as an acute poison and carcinogen. As toxicity is a major factor leading to root growth inhibition in plants. However, the molecular mechanisms of plants in response to As has not been extensively characterized. more...

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL198

15 Samples

Download data: CEL