Similar studies for GEO DataSets (Select 4487) - GEO DataSets

Select item 44871.

Ras/MEK inhibition effect on IFN-alpha treated cancer cell line: time course

Analysis of HT1080 cells treated with IFN-alpha, the Ras/MEK inhibitor U0126, or both for 6 or 12 hours. SKOV3 cells treated with IFN-alpha for 6 hours examined. HT1080 is moderately resistant to the anti-viral effects of IFN-alpha. MEK inhibition increases the sensitivity of HT1080 to IFN-alpha.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 agent, 2 cell line, 2 time sets

Platform:: GPL6244
Series:: GSE31019
30 Samples

Download data: CEL

DataSet

Accession:: GDS4487

ID:: 4487

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000310192.

Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells

(Submitter supplied) Certain oncolytic viruses exploit activated Ras signalling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-dependent viral oncolysis. Here, we identified 10 human cancer cell lines (out of 16) with increased sensitivity to the anti-viral effects of IFN-α after treatment with the MEK inhibitor U0126, suggesting that the Ras/MEK pathway underlies their reduced sensitivity to IFN. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4487
Platform:: GPL6244
30 Samples

Download data: CEL

Series

Accession:: GSE31019

ID:: 200031019

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000494693.

Oncogenic Ras inhibits IRF1 to promote viral oncolysis

(Submitter supplied) Oncolytic viruses exploit common molecular changes in cancer cells, which are not present in normal cells, to target and kill cancer cells. Ras transformation and defects in type I interferon (IFN)-mediated antiviral responses are known to be the major mechanisms underlying viral oncolysis. Previously, we demonstrated that oncogenic RAS/Mitogen-activated protein kinase kinase (Ras/MEK) activation suppresses the transcription of many IFN-inducible genes in human cancer cells, suggesting that Ras transformation underlies type I IFN defects in cancer cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE49469

ID:: 200049469

Select item 2000248904.

Genome-wide copy number variation in human metastatic melanoma cell lines

(Submitter supplied) Illumina HumanExon510S-DUO bead arrays (Illumina Inc) were performed according to the manufacturer's protocol.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:: GPL6988
4 Samples

Download data: TXT

Series

Accession:: GSE24890

ID:: 200024890

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Select item 2000248625.

Expression data from melanoma cell lines

(Submitter supplied) Differential gene expression analysis of parental and resistant sub-lines of melanoma cell lines treated or untreated with PLX4032 Using microarray we sought to obtain a genome-wide profile of differentially expressed genes in parental melanoma cell lines and resistant sub-lines in response to PLX4032 vs DMSO control treatment.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
24 Samples

Download data: CEL, TXT

Series

Accession:: GSE24862

ID:: 200024862

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Select item 2000200516.

Expression profiling of BRAFV600E melanoma cell lines upon RAF inhibition

(Submitter supplied) Microarray expression analysis to identify global changes in transcription in response to RAF inhibition. Genes under RAF control were identified in a panel of BRAFV600E tumor cells, following the short-term inhibition of RAF using a pan-RAF kinase inhibitor, PLX4032 (Plexxikon). For comparison with changes in gene expression in response to MEK inhibition using PD0325901 (Pfizer), the following array data was referenced: (http://www.ncbi.nlm.nih.gov/geo/ (accession no. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
12 Samples

Download data: CEL

Series

Accession:: GSE20051

ID:: 200020051

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Select item 2001344877.

Expression data from colorectal carcinoma HCT-15 treated with oncolytic virus M1 and U0126

(Submitter supplied) Virus infection is a kind of immune stimulation, we previously found that inhibition of Ras signaling by U0126 supress the infection of M1 virus, thus we predicted that U0126 might increase the antiviral effect, ultimately inhibit the replication of M1 virus. We plan to figure it out from the expression array data. We used microarry data to detail the expression of immune factors regulated by oncolytic virus M1 and U0126.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE134487

ID:: 200134487

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Select item 2000336558.

Whole-transcript expression data for uveal melanoma

(Submitter supplied) G protein alpha q and 11 are mutated in 90% of uveal melanoma and they activate the MAPK pathway. Using expression microarray analysis, we identified a unique MEK dependent transcriptional signature with genes that are involved in proliferation and tumor cell invasion.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
29 Samples

Download data: TXT

Series

Accession:: GSE33655

ID:: 200033655

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Select item 2000437659.

Expression data from exponentially proliferating ovarian cancer cell lines

(Submitter supplied) We used microarrays to assess gene expression in proliferating ovarian cancer cell lines

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
98 Samples

Download data: CEL

Series

Accession:: GSE43765

ID:: 200043765

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005483010.

Up-regulation of IFN-related genes in BRCA2-/- cells

(Submitter supplied) Microarray-based expression profiling of BRCA2 knockout and isogenic wild type HCT116 human colorectal cancer cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
6 Samples

Download data: CEL

Series

Accession:: GSE54830

ID:: 200054830

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Select item 20003613911.

SNP and Expression data from the Cancer Cell Line Encyclopedia (CCLE)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array

Platforms:: GPL15315 GPL15308
1864 Samples

Download data: CEL

Series

Accession:: GSE36139

ID:: 200036139

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Select item 20003613812.

SNP array data from the Cancer Cell Line Encyclopedia (CCLE)

(Submitter supplied) The Cancer Cell Line Encyclopedia (CCLE) project is a collaboration between the Broad Institute, the Novartis Institutes for Biomedical Research and the Genomics Novartis Foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models It consists of a compilation of gene expression, chromosomal copy number, and massively parallel sequencing data from nearly 1,000 human cancer cell lines. more...