Similar studies for GEO DataSets (Select 4346) - GEO DataSets

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Items: 20

Select item 43461.

Gli transcriptional repressor Gli3T effect on epithelioid carcinoma cell line Panc-1

Analysis of epithelioid carcinoma Panc1 cells expressing Gli3T, a transcriptional repressor of Gli. Gli transcription factors are essential for Kras initiation of pancreatic tumorigenesis. Results provide insight into molecular mechanisms underlying pancreatic epithelial transformation.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6244
Series:: GSE36855
6 Samples

Download data: CEL

DataSet

Accession:: GDS4346

ID:: 4346

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000368552.

Gene expression analysis in Panc-1 cells in response to treatment with Gli3T, a dominant-negative repressor of Gli

(Submitter supplied) Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive human malignancies. In our studies, we find that the Gli transcription factors are required for Kras initiation of pancreatic tumorigenesis. In order to identify the downstream transcriptional targets of Gli in PDAC, we conducted gene expression analysis using Gli3T, a transcriptional repressor of Gli. In this data set we include the expression data from 6 samples with three of them expressing a control vector and another three expressing Gli3T

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4346
Platform:: GPL6244
6 Samples

Download data: CEL, TXT

Series

Accession:: GSE36855

ID:: 200036855

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000333233.

Kras-induced ikk2/nf-kappaB activation by IL-1 alpha and p62 freedforward loops is required for development of pancreatic ductal adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL6246 GPL4134
13 Samples

Download data: CEL, TXT

Series

Accession:: GSE33323

ID:: 200033323

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000333224.

Gene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice

(Submitter supplied) Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is required for development of pancreatic ductal adenocarcinoma that was initiated by Kras activation.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE33322

ID:: 200033322

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000274785.

Gene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice

(Submitter supplied) Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kappaB activation and completely suppressed PDAC development in KrasG12D and KrasG12D;Ink4a/Arf mutant mice, demonstrating a genetic link between IKK2/beta and KrasG12D in PDAC inception. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
1 Sample

Download data: TXT

Series

Accession:: GSE27478

ID:: 200027478

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000894226.

Mutant Kras- and p16-Regulated NOX4 Activation Overcomes Metabolic Checkpoints in Development of Pancreatic Ductal Adenocarcinoma

(Submitter supplied) That mutational activation of Kras and inactivation of p16 are two signature genetic alterations required for development of PDAC. To elucidate the downstream pathways activated by oncogenic Kras and inactivated p16 in human pancreatic tumorigenesis, we profiled gene expression in HPNE/Kras/shp16 and HPNE/Kras cells using cDNA microarray analysis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
1 Sample

Download data: TXT

Series

Accession:: GSE89422

ID:: 200089422

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001074587.

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL24320 GPL15076 GPL6887
132 Samples

Download data: TXT

Series

Accession:: GSE107458

ID:: 200107458

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001074548.

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes [aCGH]

(Submitter supplied) Primary cell cultures were isolated from different KrasG12D-driven mouse models of pancreatic cancers and subjected to array comparative genomic hybridization (aCGH) for the investigation of copy number profiles.

Organism:: Mus musculus

Type:: Genome variation profiling by genome tiling array

Platforms:: GPL15076 GPL24320
115 Samples

Download data: TXT

Series

Accession:: GSE107454

ID:: 200107454

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001074469.

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes [expression]

(Submitter supplied) Primary cell cultures were isolated from KrasG12D-driven, PiggyBac transposon-transposase pancreatic cancer cell cultures and subjected to microarray-based expression profiling for the investigation of expression profiles.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
17 Samples

Download data: TXT

Series

Accession:: GSE107446

ID:: 200107446

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Select item 20002582810.

Pten deficiency cooperates with KrasG12D to activate NFkB pathway promoting the development of malignant pancreatic ductal adenocarcinoma

(Submitter supplied) Almost all human pancreatic ductal adenocarcinomas (PDACs) are driven by oncogenic Kras and the progression of the disease is characterized by the serial appearance of certain genetic lesions. Mouse models have convincingly shown that Kras mutation induces classical PanIN lesions that can progress to PDAC in the appropriate tumor suppressor background. However, the cooperative mechanism between mutant Kras-dependent signaling surrogates and other oncogenic pathways remains to be fully elucidated in order to devise better therapeutic strategy. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4528
Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE25828

ID:: 200025828

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 452811.

KrasG12D pancreatic ductal epithelial cells deficient in PTEN

Analysis of primary pancreatic ductal epithelial cells (PDECs) established from 6-week-old Pdx1-Cre;LSL-KrasG12D L/+;Pten L/+ animals. Oncogenic KrasG12D and Pten deficiency cooperate to induce pancreatic ductal adenocarcinoma (PDAC). Results provide insight into molecular basis of PDAC development.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE25828
8 Samples

Download data: CEL

DataSet

Accession:: GDS4528

ID:: 4528

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20003970412.

Identification of ZIC2 target genes in human pancreatic cancer cell lines PANC-1 and KP-4

(Submitter supplied) PANC-1Tet/ZIC2 and PANC-1Tet/empty were established from human pancreatic cancer cell line PANC-1. PANC-1Tet/ZIC2 cells express FLAG-tagged human ZIC2 on the withdrawal of DOX. On the other hand, PANC-1Tet/empty was transfected an empty vector for the control experiment. To identify ZIC2 target genes, total RNAs were purified from the cells before and 48 hours after the DOX withdrawal. Gene expression profiles were analyzed by AGILENT human 4x44k cDNA microarray. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platform:: GPL10332
6 Samples

Download data: TXT

Series

Accession:: GSE39704

ID:: 200039704

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005520913.

Regulation of GLI underlies a role for BET bromodomains in pancreatic cancer growth and the tumor microenvironment

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) is extraordinarily chemoresistant and the abundant stromal content of these tumors contributes to the ineffective treatment of this disease. While the genetic alterations of PDAC have been well characterized, the epigenetic pathways regulating PDAC remain, for the most part, elusive. Employing an in vivo shRNA screen targeting epigenetic regulators, we identified members of the BET family of chromatin adaptors as key regulators of PDAC cell growth and maintenance of the tumor stroma. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
40 Samples

Download data: TXT

Series

Accession:: GSE55209

ID:: 200055209

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010884314.

TGIF1 loss contributes to progression of KRASG12D-induced pancreatic ductal adenocarcinoma involving HAS2-CD44 activation and PD-L1 upregulation.

(Submitter supplied) Transcriptional profiling of mouse Pancreatic cancer cells comparing Pdx1-Cre LSL-KrasG12D TGIF1L/L P53L/L cells with Pdx1-Cre LSL-KrasG12D P53L/L cells, and to determine the effects of TGIF1 deletion on PDAC gene expression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL

Series

Accession:: GSE108843

ID:: 200108843

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008552115.

Murine Pancreatic Cancer Cells: KLF10 wild type vs KLF10 knockout

(Submitter supplied) Transcriptional profiling of mouse pancreatic cancer cells comparing Pdx-1Cre LSL-KrasG12D P53L/L cells with Pdx-1Cre LSL-KrasG12D KLF10L/L P53L/L cells, and to determine the effects of KLF10 deficiency on murine PDAC gene expression.