Similar studies for GEO DataSets (Select 4335) - GEO DataSets

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Items: 20

Select item 43351.

Sox9+ pancreatic cells: developmental time course

Analysis of GFP positive cells from Sox9-EGFP pancreas isolated by FACS at various developmental stages: e10.5, e15.5, p23. Results provide insight into molecular mechanisms underlying differentiatiation of Sox9+ embryonic pancreatic progenitors into adult ductal cells or the endocrine lineage.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 age, 3 cell type sets

Platform:: GPL6246
Series:: GSE34060
15 Samples

Download data: CEL

DataSet

Accession:: GDS4335

ID:: 4335

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000340602.

Expression data of Sox9+ and Ngn3+ mouse pancreas cells at different stages of development

(Submitter supplied) Genes specific to Sox9+ pancreatic progenitors were identified by comparing the gene expression in embryonic and adult Sox9+ cells. We used microarray analysis to detail the global changes in gene expression as Sox9 positive embryonic pancreatic progenitors differentiatiate into adult ductal cells or the endocrine lineage.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4335
Platform:: GPL6246
15 Samples

Download data: CEL

Series

Accession:: GSE34060

ID:: 200034060

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000286713.

Identification of Sox9-Regulated Pathways During Pancreas Development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL7202 GPL4134
16 Samples

Download data: TXT

Series

Accession:: GSE28671

ID:: 200028671

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000286704.

Identification of Sox9-Regulated Pathways During the Secondary Transition Stage of Pancreas Development

(Submitter supplied) Sox9 target genes were identified during the secondary transition stage of pancreas development by comparing gene expression in Sox9-ablated versus wild-type pancreata using microarray analysis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
8 Samples

Download data: TXT

Series

Accession:: GSE28670

ID:: 200028670

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000286695.

Identification of Sox9-Regulated Pathways During Early Pancreas Organogenesis

(Submitter supplied) Sox9 target genes were identified by comparing gene expression in Sox9-ablated versus wild-type pancreata using microarray analysis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
8 Samples

Download data: TXT

Series

Accession:: GSE28669

ID:: 200028669

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000648546.

Expression by CD133+ cells isolated from the adult human exocrine pancreas

(Submitter supplied) Expression from CD133+ cells isolated from adult human exocrine tissue was compared to a CD133-depleted cell population

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: DIFF

Series

Accession:: GSE64854

ID:: 200064854

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000308027.

Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming

(Submitter supplied) Aims/hypothesis: Duct cells isolated from adult human pancreas can be reprogrammed to express islet beta cell genes by adenoviral transduction of the developmental transcription factor neurogenin3 (Ngn3). In this study we aimed to fully characterize the extent of this reprogramming and intended to improve it. Methods: The extent of the Ngn3-mediated duct-to-endocrine cell reprogramming was measured employing genome wide mRNA profiling. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL97
26 Samples

Download data: CEL

Series

Accession:: GSE30802

ID:: 200030802

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000036538.

Inducible Ngn3 Embryonic Stem Cells

(Submitter supplied) Expression of the proendocrine gene neurogenin 3 (Ngn3) is required for the development of pancreatic islets. In order to better characterize the molecular events regulated by Ngn3 during development, we have determined the expression profile of differentiating murine embryonic stem cells (mESCs) uniformly induced to overexpress Ngn3. An ESC line was created that allows for the induction of Ngn3 by adding doxycycline (Dox) to the culture medium. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2276
Platform:: GPL1261
16 Samples

Download data: CEL, XLS

Series

Accession:: GSE3653

ID:: 200003653

Select item 22769.

Embryonic stem cell line response to the conditional expression of neurogenin 3

Analysis of transgenic embryonic stem cells induced with doxycycline to express neurogenin 3 (Ngn3) and differentiated for 3 or 10 days as embryoid bodies. Ngn3 is required for pancreatic islet development. Results provide insight into Ngn3-regulated molecular events during development.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell line, 3 development stage, 3 time sets

Platform:: GPL1261
Series:: GSE3653
16 Samples

Download data: CEL

DataSet

Accession:: GDS2276

ID:: 2276

Select item 20009670710.

Multi-site Neurogenin3 phosphorylation controls pancreatic endocrine differentiation: transcriptomic analysis of pancreatic organoids overexpressing wild type and phosphomutant Neurogenin3

(Submitter supplied) The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation. While previous studies have focused on Ngn3 gene function, little is known about the regulation of Ngn3 protein. Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (cdk)-mediated phosphorylation on multiple serine-proline sites. Replacing wild-type protein with a phosphomutant form of Ngn3 increases α-cell generation, the earliest endocrine cell type to be formed in developing pancreas. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
77 Samples

Download data: TXT

Series

Accession:: GSE96707

ID:: 200096707

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006202311.

Identification of Sox9/Pdx1-coregulated Genes During Pancreas Organogenesis

(Submitter supplied) Sox9/Pdx1 co-regulated target genes were identified by comparing gene expression in Sox9/Pdx1-double heterozygates versus Sox9- or Pdx1- heterozygates pancreata using microarray analysis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
9 Samples

Download data: TXT

Series

Accession:: GSE62023

ID:: 200062023

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006194812.

Transcriptome and cistrome analysis reveals synergistic roles for Sox9 and Pdx1 in lineage allocation of foregut progenitor cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL9052 GPL7202
15 Samples

Download data: TXT

Series

Accession:: GSE61948

ID:: 200061948

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006194713.

SOX9 targets in hESC-derived pancreatic progenitors

(Submitter supplied) Our lab identified Sox9 as a specific marker and maintenance factor of mouse pancreatic progenitors (Seymour et al., PNAS, 2007). Here was wanted to identify direct targets of Sox9 in pancreatic progenitors. However, due to the limited number of pancreatic progenitors in the developing mouse, we used in vitro derived pancreatic progenitors to determine direct targets of Sox9. We performed ChIP-seq analysis for Sox9 and determined its direct targets in the human genome. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
2 Samples

Download data: TXT

Series

Accession:: GSE61947

ID:: 200061947

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006194614.

hESC-derived liver transcriptome analysis

(Submitter supplied) To characterize the transcriptional programs that underlie pancreas differentiation and identity, we have generated genome-scale expression profiles by RNA-seq from human embryonic stem cell derived liver progenitors and human fetal pancreatic tissue (days 54-57 post conception). These samples were compared to those already published transcriptomes (Xie et al., 2013). Together, these samples were used to perform principles compotent analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9052
2 Samples

Download data: TXT

Series

Accession:: GSE61946

ID:: 200061946

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20006194515.

Human fetal pancreas transcriptome analysis

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9052
2 Samples

Download data: TXT

Series

Accession:: GSE61945

ID:: 200061945

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20002636616.

Notch/HES1-mediated PARP1 activation: A cell-type specific mechanism for tumor suppression

(Submitter supplied) Notch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T cell acute lymphoblastic leukemia (T-ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-ALL leads to growth arrest and apoptosis. The Notch target Hairy/Enhancer of Split1 (HES1) is sufficient to reproduce this tumor suppressor phenotype in B-ALL, however the mechanism is not yet known. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
206 Samples

Download data: CEL

Series

Accession:: GSE26366

ID:: 200026366

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002375217.

Induced overexpression of Pdx1 and Ngn3 in a mouse ES cell-derived endoderm population induces pancreatic differentiation

(Submitter supplied) Induced overexpression of Pdx1 in activin-induced endoderm population resulted in the upregulation of pancreas-related genes such as insulin 1 and 2 at day 20. To enhance the developmental progression from the pancreatic bud to the formation of the endocrine lineages, we next expressed neurogenin3 (Ngn3) together with Pdx-1. Induced overexpression of Pdx1 together with Ngn3 dramatically increased Insulin 1 mRNA by day 9 differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL2897
10 Samples

Download data: TXT

Series

Accession:: GSE23752

ID:: 200023752

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004746618.

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embyronic and induced pluripotent cells

(Submitter supplied) Notch signaling regulates several cellular processes including cell fate decisions and proliferation in both invertebrates and mice. However, comparatively less is known about the role of Notch during early human development. Here, we examined the function of Notch signaling during hematopoietic lineage specification from human pluripotent stem cells (hPSCs) of both embryonic and adult fibroblast origin. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
8 Samples

Download data: CEL

Series

Accession:: GSE47466

ID:: 200047466

Select item 20013803819.

Investigating Ngn3-expressing cells in the adult mouse pancreas

(Submitter supplied) The beta cell mass of the adult pancreas is thought to be maintained through low-level proliferation. Ductal cells have been proposed as an alternative source of beta cells in vivo, but this remains controversial. By performing detailed lineage tracing analysis, 3D imaging and single cell RNA sequencing we investigated if ductal cells contribute to the beta cell mouse in the adult mouse.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
3 Samples

Download data: CSV

Series

Accession:: GSE138038

ID:: 200138038

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008690920.

NFIA regulates pancreatic cell fate and adult physiology through vesicle trafficking

(Submitter supplied) Intracellular trafficking is essential for proper cell signaling. In the pancreas, secretory cells rely on trafficking to regulate blood glucose and digestion. Pancreatic disorders reflect defects in function or development, evoking considerable interest in understanding the molecular genetics governing pancreatic organogenesis. Here, we show the transcription factor NFIA regulates trafficking in both the embryonic and adult pancreas, affecting both developmental cell fate decisions and adult physiology. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: DIFF

Series

Accession:: GSE86909

ID:: 200086909

PubMed Similar studies SRA Run Selector

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