|
| Status |
Public on Aug 02, 2012 |
| Title |
Identification of Sox9-Regulated Pathways During Early Pancreas Organogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Sox9 target genes were identified by comparing gene expression in Sox9-ablated versus wild-type pancreata using microarray analysis.
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| |
|
| Overall design |
Sox9 was conditionally ablated in the developing pancreas via recombination of a Sox9-flox allele (Kist et al., 2002) using the Pdx1-Cre transgene (Gu et al., 2002). Total RNA was isolated and pooled from dorsal pancreatic epithelia of e12.5 Sox9fl/fl; Pdx1-Cre (mutant) versus Sox9fl/fl (wild-type) littermates for three biological replicates.
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| |
|
| Contributor(s) |
Shih H, Seymour PA, Sander M |
| Citation(s) |
22675211, 22874919 |
| |
| Submission date |
Apr 16, 2011 |
| Last update date |
May 10, 2018 |
| Contact name |
Brandon Taylor |
| Organization name |
University of California, San Diego
|
| Department |
Pediatrics and Cellular & Molecular Medicine
|
| Lab |
Maike Sander, M.D.
|
| Street address |
Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Dr., Room 3101
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
|
| Samples (8)
|
| GSM710259 |
dorsal pancreatic epithelia-e12.5-WT-1 |
| GSM710260 |
dorsal pancreatic epithelia-e12.5-WT-2 |
| GSM710261 |
dorsal pancreatic epithelia-e12.5-WT-3 |
| GSM710262 |
dorsal pancreatic epithelia-e12.5-WT-4 |
| GSM710263 |
dorsal pancreatic epithelia-e12.5-MUT-1 |
| GSM710264 |
dorsal pancreatic epithelia-e12.5-MUT-2 |
| GSM710265 |
dorsal pancreatic epithelia-e12.5-MUT-3 |
| GSM710266 |
dorsal pancreatic epithelia-e12.5-MUT-4 |
|
| This SubSeries is part of SuperSeries: |
| GSE28671 |
Identification of Sox9-Regulated Pathways During Pancreas Development |
|
| Relations |
| BioProject |
PRJNA143089 |
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