Similar studies for GEO DataSets (Select 4091) - GEO DataSets

Select item 40911.

Cancer stem cell population in highly metastatic variants of MDA-MB-231 breast cancer cell line

Analysis of CD24-/CD44+/ESA+ cancer stem cells from MDA-MB-231 breast cancer (BC) cell line and its highly metastatic variants 231BoM-1833 and 231BrM-2a. The majority of BC deaths are attributed to metastatic disease. Results provide insight into the molecular basis of metastatic progression.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 cell line, 2 genotype/variation sets

Platform:: GPL6244
Series:: GSE25976
6 Samples

Download data: CEL

DataSet

Accession:: GDS4091

ID:: 4091

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000259762.

Expression profiles of CD24-/CD44+/ESA+ population in MDA-MB-231 and its highly metastatic variants.

(Submitter supplied) Breast cancer is a curable disease if it is diagnosed at an early stage. However, only little options are left once the tumor is metastasized to distant organs, and more than 90% of breast cancer death is attributed to metastatic disease. The process of metastasis is highly complex and involves many steps for successful colonization of tumor cells at a target organ. According to the cancer stem cell (CSC) theory, which still remains a hypothesis, these metastatic cells must have stem cell-like capability for their self-renewal in addition to their invasive ability. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4091
Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE25976

ID:: 200025976

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000456133.

Expression data from CD44-knockdown MDA-MB-231 human breast cancer cells.

(Submitter supplied) CD44, an adhesion molecule that binds to extracellular matrix, primarily to hyaluronan (HA), has been implicated in cancer cell migration, invasion, and metastasis. CD44 has also recently been recognized as a marker for stem cells of several types of cancer. However, the roles of CD44 in the development of bone metastasis still remain unclear. To explore this issue, we established the MDA-MB-231 human breast cancer cells stably expressing short hairpin RNA against CD44.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10332
3 Samples

Download data: TXT

Series

Accession:: GSE45613

ID:: 200045613

Select item 2001574974.

Gene expression of S100A10 knocked down human breast cancer cells

(Submitter supplied) The expression level of S100A10 was much higher in the CD44+ cancer cells metastasized to the liver than those at the primary site in the breast cancer patient-derived tumor xenograft mice. Expression level of S100A10 increased by the oncoprotein, PML/RARα and RAS, and its higher expression is linked to worse outcome in a number of cancer types including breast cancers

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
6 Samples

Download data: CEL

Series

Accession:: GSE157497

ID:: 200157497

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001511915.

Gene expression of breast cancer stem cells.

(Submitter supplied) Metastatic progression remains the major cause of death in human breast cancer. Cancer cells with cancer stem cell (CSC) properties drive initiation and growth of metastases at distant sites. We have previously established the breast cancer patient-derived tumor xenograft (PDX) mouse model in which CSC marker CD44+ cancer cells formed spontaneous microscopic metastases in the liver. In this PDX mouse, the expression levels of S100A10 and its family proteins were much higher in the CD44+ cancer cells metastasized to the liver than those at the primary site.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
8 Samples

Download data: TXT

Series

Accession:: GSE151191

ID:: 200151191

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000244606.

Prolonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics.

(Submitter supplied) Background: Cancer stem cells are presumed to have virtually unlimited proliferative and self-renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with overexpression of ATP-binding cassette transporters. We investigated whether prolonged continuous selection of cells for drug resistance enriches cultures for cancer stem-like cells. Methods: Cancer stem cells were defined as CD44+/CD24– cells that could self-renew (ie, generate cells with the tumorigenic CD44+/CD24– phenotype), differentiate, invade, and form tumors in vivo. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4084
Platform:: GPL571
4 Samples

Download data: CEL

Series

Accession:: GSE24460

ID:: 200024460

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 40847.

Doxorubicin-resistant MCF-7/ADR breast cancer cells

Analysis of weakly tumorigenic parental MCF-7 cells and a multistep doxorubicin-selected MCF-7/ADR subline. Results provide insight into whether prolonged continuous selection of cells for drug resistance enriches for cancer stem-like cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 cell line, 2 genotype/variation sets

Platform:: GPL571
Series:: GSE24460
4 Samples

Download data: CEL

DataSet

Accession:: GDS4084

ID:: 4084

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2002097438.

Effect of endothelial-specific endorepellin expression on gene expression of breast cancer allografts in Tie2CreER;ERKi mice

(Submitter supplied) To explore the translational implications of endorepellin in breast cancer, we created a double transgenic, inducible Tie2CreER;ERKi mouse line that expresses recombinant endorepellin specifically from the endothelium. We investigated the therapeutic effects of recombinant endorepellin overexpression in an orthotopic, syngeneic breast cancer allograft mouse model. Tamoxifen-induced expression of recombinant endorepellin specifically from the endothelium in Tie2CreER;ERKi mice markedly suppressed breast cancer allograft growth, hyaluronan deposition in the tumor proper and perivascular tissues, and tumor angiogenesis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: TXT

Series

Accession:: GSE209743

ID:: 200209743

PubMed Full text in PMC Similar studies

Select item 2001486579.

Hyaluronan-CD44 signaling promotes pro-tumor inflammation in breast cancer

(Submitter supplied) We report the application of next-generation sequencing (NGS) technology for high-throughput profiling of RNA expression in human breast cancer cells. The goal of this study was to compare NGS-derived transcriptome profiling (RNA-seq) from cells expressing either wildtype or knockout CD44 to identify key downstream signaling events of HA-CD44 interactions. Methods: This experiment was repeated for a total of three times and replicate RNA samples were extracted and submitted for Illumina Sequencing. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE148657

ID:: 200148657

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

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