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| Status |
Public on Dec 22, 2020 |
| Title |
Gene expression of breast cancer stem cells. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Metastatic progression remains the major cause of death in human breast cancer. Cancer cells with cancer stem cell (CSC) properties drive initiation and growth of metastases at distant sites. We have previously established the breast cancer patient-derived tumor xenograft (PDX) mouse model in which CSC marker CD44+ cancer cells formed spontaneous microscopic metastases in the liver. In this PDX mouse, the expression levels of S100A10 and its family proteins were much higher in the CD44+ cancer cells metastasized to the liver than those at the primary site.
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| |
|
| Overall design |
Duplicated analyses of gene expression of the cancer stem cell marker CD44-positive breast cancer patient-derived xenograft (PDX) cells collected separately from the two breast cancer PDX mice.
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| |
|
| Contributor(s) |
Shimono Y, Nishimura T, Gotoh N |
| Citation(s) |
32976661 |
| |
| Submission date |
May 26, 2020 |
| Last update date |
Dec 22, 2020 |
| Contact name |
Nishimura Tatsunori |
| E-mail(s) |
tatsunori323@med.nagoya-u.ac.jp
|
| Organization name |
Nagoya University
|
| Department |
Graduate School of Medicine
|
| Lab |
Division of Cancer Biology
|
| Street address |
65 Tsurumai-cho, Showa-ku
|
| City |
Nagoya |
| State/province |
Aichi |
| ZIP/Postal code |
466-8550 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL21185 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
|
| Samples (8)
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|
| Relations |
| BioProject |
PRJNA635100 |
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