GEO DataSets

Analysis of H4-II-E-C3 liver-derived cells exposed to toxic heavy metals: nickel II chloride (NiCl2), cadmium chloride (CdCl2), or sodium dichromate (Na2Cr2O7), at various concentrations (based on viability assays). Results provide insight into molecular mechanisms underlying Ni, Cd and Cr toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 4 agent, 10 dose sets

Platform:

GPL1355

Series:

GSE31503

44 Samples

Download data: CEL

(Submitter supplied) Many heavy metals, including nickel (Ni), cadmium (Cd), and chromium (Cr) are toxic industrial chemicals with an exposure risk in both occupational and environmental settings that may cause harmful outcomes. While these substances are known to produce adverse health effects leading to disease or health problems, the detailed mechanisms remain unclear. To elucidate the processes involved in the of toxicity of nickel, cadmium, and chromium at the molecular level and to perform a comparative analysis, H4-II-E-C3 rat liver-derived cell lines were treated with soluble salts of each metal using concentrations derived from viability assays, and gene expression patterns were determined with DNA microarrays. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3928

Platform:

GPL1355

44 Samples

Download data: CEL

(Submitter supplied) U.S. Service Members and civilians are at risk of exposure to a variety of environmental health hazards throughout their normal duty activities and in industrial occupations. Metals are widely used in large quantities in a number of industrial processes and are a common environmental toxicant, which increases the possibility of being exposed at toxic levels. While metal toxicity has been widely studied, the exact mechanisms of toxicity remain unclear. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

59 Samples

Download data: CEL

(Submitter supplied) Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic, long term exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, as well as exposures to military personnel. While the toxic effects of cobalt have been widely studied, the exact mechanisms of toxicity remain unclear. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS4953 GDS4954

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of MH1C1 liver cells exposed to 160 or 310 uM cobalt chloride. Cobalt (Co) is a heavy metal found naturally in low concentrations and used in military and industrial applications. Co exposure can result in adverse health effects. Results provide insight into the mechanisms of Co toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:

GPL1355

Series:

GSE51207

12 Samples

Download data: CEL

Analysis of H4IIEC3 liver cells exposed to 29 or 62 uM cobalt chloride. Cobalt (Co) is a heavy metal found naturally in low concentrations and used in military and industrial applications. Co exposure can result in adverse health effects. Results provide insight into the mechanisms of Co toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:

GPL1355

Series:

GSE51207

12 Samples

Download data: CEL

(Submitter supplied) Our main objectives were: 1) to identify transcriptional signatures specific to the exposure to two metals: Ni and Cd; 2) to investigate the mechanisms of toxicity for these two metals; and 3) to develop a predictive tool to identify the sublethal effects of Ni and Cd contaminants in fish sampled from natural environments. The molecular mechanisms underlying nickel (Ni) and cadmium (Cd) toxicity and their specific effects on fish are poorly understood. more...

Organism:

Perca flavescens

Type:

Expression profiling by array

Platform:

GPL17732

176 Samples

Download data: TXT

(Submitter supplied) From the result of comparative the gene expression analyses of human hepatoma cell line, HepG2 following exposures of three heavy metals; arsenic, cadmium and nickel and three carcinogens; N-dimethylnitrosoamine (DMN), 12-O-tetradecanoylphorbol-13-acetate (TPA) and tetrachloroethylene (TCE), 31-55% of the genes altered by As, Cd and Ni exposure were overlapped with those by three model carcinogen exposures in our experiments. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

33 Samples

Download data: CEL

(Submitter supplied) The recent development of a custom cDNA microarray platform for one of thé standard organisms in aquatic toxicology, Daphnia magna, opened up new ways to mechanistic insights of toxicological responses. In this study, gene expression and (sub)organismal responses (Cellular Energy Allocation, growth) were assayed after short-term waterborne metal exposure. Microarray analysis of Ni-exposed daphnids revealed several affected functional gene classes, of which the largest ones were involved in different metabolic processes (mainly protein and chitin related processes), cuticula turnover, transport and signal transduction. more...

Organism:

Daphnia magna

Type:

Expression profiling by array

Platform:

GPL7742

21 Samples

Download data: GPR

(Submitter supplied) We are investigating the response of human lymphoblastoid cells to low-dose exposure of environmental metals We used microarrays to detail the global programme of gene expression upon response to low-dose metals Keywords: dose

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4915 GDS4916

Platform:

GPL6244

8 Samples

Download data: CEL

Analysis of TK6 lymphoblastoid cells treated with 0.1 uM cadmium chloride for 24 hours. Results provide insight into the molecular impact resulting from exposure to an environmentally relevant dose of cadmium.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6244

Series:

GSE20320

4 Samples

Download data: CEL

Analysis of TK6 lymphoblastoid cells treated with 0.1 uM sodium arsenite for 24 hours. Results provide insight into the molecular impact resulting from exposure to an environmentally relevant dose of arsenic.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6244

Series:

GSE20320

4 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

16 Samples

Download data: TXT

(Submitter supplied) To unravel possible mechanisms of Cd tissue-specificity, and to further deepen the understanding of cadmium mechanisms, we have compared transcriptomics data from cell models representative of three major Cd targets: pulmonary (A549), hepatic (HepG2), and neuronal (SH-SY-5Y) cells. Results from KEGG analysis show that only one specific pathway is dysregulated in a significant way in all cell models: the mineral absorption pathway.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

8 Samples

Download data: TXT

(Submitter supplied) To unravel possible mechanisms of Cd tissue-specificity, and to further deepen the understanding of cadmium mechanisms, we have compared transcriptomics data from cell models representative of three major Cd targets: pulmonary (A549), hepatic (HepG2), and neuronal (SH-SY-5Y) cells. Results from KEGG analysis show that only one specific pathway is dysregulated in a significant way in all cell models: the mineral absorption pathway.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

8 Samples

Download data: TXT