Similar studies for GEO DataSets (Select 3386) - GEO DataSets

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Items: 20

Select item 33861.

Heart failure progression model: non-infarcted ventricular tissue

Analysis of non-infarcted left ventricular tissues from animals at various time points up to 14 days following myocardial infarction (MI). MI induced by ligating the left coronary artery. Results provide insight into the molecular pathogenesis of heart failure.

Organism:: Mus musculus

Type:: Expression profiling by array, log2 ratio, 4 time sets

Platform:: GPL891
Series:: GSE6580
20 Samples

Download data

DataSet

Accession:: GDS3386

ID:: 3386

Select item 2000065802.

Molecular alterations following myocardial infarction in mice

(Submitter supplied) Background and Aims: It is known that inflammatory processes are activated in heart failure, but the regulation of cytokines and their role in the pathogenesis of the disease are not well understood. To address this issue, we have performed microarray analysis of non-infarcted left ventricular tissue from mice at various time-points after myocardial infarction. Methods: Molecular alterations in myocardial tissue were measured 3, 5, 7 and 14 days after induced infarction by using cDNA microarrays. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3386
Platform:: GPL891
20 Samples

Download data

Series

Accession:: GSE6580

ID:: 200006580

Select item 2000019573.

MI: 1 and 7 days post-op

(Submitter supplied) 1-day and 7-day sham and MI hearts Keywords = Heart Keywords = Mycardial infarction Keywords = 1 day post-MI Keywords = 7 day post-MI Keywords: parallel sample

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2145
Platform:: GPL153
24 Samples

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Series

Accession:: GSE1957

ID:: 200001957

Select item 21454.

Congestive heart failure model

Analysis of the heart left ventricle 1 or 7 days after ligation of the left anterior descending coronary artery to induce myocardial infarction (MI). Animals subjected to MI had congestive heart failure (CHF) on day 7. Results identify genes involved in the progression to CHF.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 disease state, 2 time sets

Platform:: GPL153
Series:: GSE1957
24 Samples

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DataSet

Accession:: GDS2145

ID:: 2145

Select item 2001570355.

RNA sequencing of genes expressed by macrophages isolated from hearts control (cts), with compensated concentric hypertrophy (HCC) or with heart failure (IC)

(Submitter supplied) purpose: to use a transcriptomic approach (RNAseq) to compare control, HCC and IC macrophage gene expression.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE157035

ID:: 200157035

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000216106.

Gene expression analysis in non-failing and failing myocardium pre and post pulsatile and non-pulsatile VAD support

(Submitter supplied) Mechanical unloading by ventricular assist devices (VAD) leads to significant gene-expression changes often summarized as reverse remodeling. However, little is known on individual transcriptome changes during VAD-support and its relationship to non-failing hearts (NF). In addition no data are available for the transcriptome regulation during non-pulsatile VAD-support. Therefore we analysed the gene-expression patterns of 30 paired samples from VAD-supported (including 8 non-pulsatile VADs) and 8 non-failing control hearts (NF) using the first total human genome-array available. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
68 Samples

Download data: CEL, TXT

Series

Accession:: GSE21610

ID:: 200021610

Select item 2000107487.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3643
Platform:: GPL1355
24 Samples

Download data: CEL

Series

Accession:: GSE10748

ID:: 200010748

Select item 36438.

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 6 dose sets

Platform:: GPL1355
Series:: GSE10748
24 Samples

Download data: CEL

DataSet

Accession:: GDS3643

ID:: 3643

Select item 2000127529.

Gene expression data from corticosteroid-treated neonatal rat cardiomyocytes

(Submitter supplied) Recent studies have highlighted the role of adrenal corticosteroid signaling in cardiac physiology and pathophysiology. It is known that glucocorticoids and aldosterone are able to bind glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and these ligand-receptor interactions are redundant. Therefore, it has been impossible to delineate how these nuclear receptors couple with corticosteroid ligands and differentially regulate gene expression for operation of their distinct functions in the heart. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL1355
12 Samples

Download data: CEL

Series

Accession:: GSE12752

ID:: 200012752

Select item 20000524710.

Altered expression of a limited number of genes contributes to cardiac decompensation during chronic pacing in dogs

(Submitter supplied) We have used chronic cardiac pacing in conscious dogs to study mechanism related to the development of dilated cardiomyopathy and the transition from compensated dysfunction (CD) to decompensated heart failure (HF). This occurs from the 3rd to 4th week of pacing with end-stage HF at 30?1 days. Keywords: disease state analysis

Organism:: Canis lupus familiaris

Type:: Expression profiling by array

Dataset:: GDS2424
Platform:: GPL3979
12 Samples

Download data: CEL

Series

Accession:: GSE5247

ID:: 200005247

Select item 242411.

Pacing-induced heart failure model: time course

Analysis of hearts of animals subjected to chronic cardiac pacing for 3 or 4 weeks. The transition from compensated dysfunction to decompensated heart failure (HF) occurs between the third and fourth week of pacing. Results provide insight into the progression to decompensated HF.

Organism:: Canis lupus familiaris

Type:: Expression profiling by array, count, 2 protocol, 3 time sets

Platform:: GPL3979
Series:: GSE5247
12 Samples

Download data: CEL

DataSet

Accession:: GDS2424

ID:: 2424

Select item 20000944512.

Low and High Capacity Runners - Sedentary and Trained: Left Ventricle

(Submitter supplied) Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between aerobic capacity and cardiac gene expression we examined genome-wide gene expression in hearts of rats artificially selected for high- and low running capacity (HCR and LCR, respectively) over 16 generations. HCR were born with an athletic phenotype, whereas LCR exhibited features of the metabolic syndrome. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3131
Platform:: GPL1355
16 Samples

Download data: CEL

Series

Accession:: GSE9445

ID:: 200009445

Select item 313113.

Hearts from low and high capacity runners with and without exercise training

Analysis of hearts from low (LCRs) and high capacity runners (HCRs) with or without exercise training. Aerobic capacity is a strong predictor of cardiovascular mortality. Results provide insight into the molecular basis for the difference in inborn aerobic capacity in the LCRs and HCRs.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 2 protocol, 2 strain sets

Platform:: GPL1355
Series:: GSE9445
16 Samples

Download data: CEL

DataSet

Accession:: GDS3131

ID:: 3131

Select item 20000287614.

Obesity impact on the left ventricular transcriptome of 4 and 10 months old SHHF rats

(Submitter supplied) Impact of the obesity on RNA total levels of male SHHF left ventricular aged from 4 and 10 months old. Keywords: Comparative cDNA hybridization

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2542
Platform:: GPL2580
20 Samples

Download data: XLS

Series

Accession:: GSE2876

ID:: 200002876

Select item 254215.

Heart failure in obesity model

Analysis of left heart ventricles of 4 and 10-month old SHHF obese animals homozygous for leptin receptor (ObR) mutation. This mutant is obese at 4 months of age and prone to heart failure after 14 months. Results provide insight into molecular basis of the contribution of obesity to heart failure.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 age, 2 disease state sets

Platform:: GPL2580
Series:: GSE2876
20 Samples

Download data: XLS

DataSet

Accession:: GDS2542

ID:: 2542

Select item 20000329316.

Leptin Regulated Mouse Gallbladder Genes

(Submitter supplied) Gallstone disease is a major contributor to health care costs in the United States. Approximately 12 % of the U.S. population has gallstones. As a result, more than 700,000 cholecystectomies are performed in this country each year. Many of these patients are obese and have a positive family history; but surprisingly, little is known about the link between obesity, genetics and gallstone formation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1509
Platform:: GPL1261
8 Samples

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Series

Accession:: GSE3293

ID:: 200003293

Select item 150917.

Leptin effect on gallbladder

Expression profiling of gallbladders from 12 leptin-deficient obese females following daily treatment with 5 ug/g recombinant leptin for 4 weeks. Studies indicate that leptin plays a role in gallbladder motility. Results provide insight into the role of leptin in gallstone disease.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1261
Series:: GSE3293
8 Samples

Download data

DataSet

Accession:: GDS1509

ID:: 1509

Select item 20001870318.

Cardiac gene expression and systemic cytokine profile are complementary in a murine model of post ischemic heart failure

(Submitter supplied) After myocardial infarction (MI) activation of the immune system and inflammatory mechanisms, among others, can lead to ventricular remodeling and heart failure (HF). Interaction between these systemic alterations and corresponding changes in the heart has not been extensively examined in the setting of chronic ischemia. The main purpose of this study was to investigate alterations in cardiac gene and systemic cytokine profile in mice with post-ischemic HF. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3655
Platform:: GPL5371
8 Samples

Download data: GPR

Series

Accession:: GSE18703

ID:: 200018703

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 365519.

Post-ischemic heart failure model

Analysis of C57BL/6 hearts 7 weeks after inducing myocardial infarction. Myocardial infarcts were produced by ligation of the descending branch of the left coronary artery. Results provide insight into the molecular pathogenesis of post-ischemic heart failure.

Organism:: Mus musculus

Type:: Expression profiling by array, log2 ratio, 2 disease state sets

Platform:: GPL5371
Series:: GSE18703
8 Samples

Download data: GPR

DataSet

Accession:: GDS3655

ID:: 3655

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20000432720.

Modulation of cardiomyocyte gene expression by n-3 PUFA supplementation

(Submitter supplied) Despite the recognized protective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cardiovascular diseases, and the demonstration of the control of gene expression by polyunsaturated fatty acids (PUFAs), the effects of these n-3 fatty acids on the whole genoma has never been investigated in cardiac cells. Using rat arrays, the effects of Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) supplementation on the global gene expression profile were evaluated in cultured neonatal rat cardiomyocytes. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2607
Platform:: GPL890
4 Samples

Download data

Series

Accession:: GSE4327

ID:: 200004327

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