Similar studies for GEO DataSets (Select 2707) - GEO DataSets

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Items: 19

Select item 27071.

Neuralized embryoid bodies response to Hedgehog agonist

Analysis of neuralized embryoid bodies (EBs) treated with a Hedgehog (Hh) agonist. EBs neuralized with retinoic acid. Hh signaling is mediated by Ci/Gli zinc finger domain-containing transcription regulators. Results used to identify gene targets of Gli.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1261
Series:: GSE4936
8 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2707

ID:: 2707

Select item 2000056832.

Identification of Gli-Act targets in the mouse ventral neural tube by ChIP

(Submitter supplied) In studies investigating Sonic hedgehog (Shh) mediated patterning of the ventral neural tube, a process where Shh acts as a morphogen, we have investigated the transcriptional network underlying neural tube specification. Adopting an ES-cell based Shh neuronal specification assay (embryoid body; EBs) and a FLAG-tagged Gli protein (a transcriptional effector of the Shh pathway), we identified a number of direct targets of Gli action using Chromatin Immunoprecipitation (ChIP). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL4245
12 Samples

Download data: BED, TXT

Series

Accession:: GSE5683

ID:: 200005683

Select item 2000049363.

Transcriptional Profiling of Hh-Treated Embryoid Bodies

(Submitter supplied) This experiment was specifically designed to measure neural targets of Shh signaling, we sought to profile the genes upregulated by Hh signaling in the ventral neural tube to obtain a valid dataset. To obtain ventral-specific markers, we generated retinoic acid-treated EBs grown in the presence or absence of HH-Ag. We did not observe induction of ventral Hh markers in RA-treated constitutive Gli1FLAG EBs and used these for the control, baseline set. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2707
Platform:: GPL1261
8 Samples

Download data: CEL, EXP

Series

Accession:: GSE4936

ID:: 200004936

Select item 2000110774.

A Genome-Scale Analysis of the Cis-Regulatory Circuitry Underlying Hedgehog Mediated Patterning of the Mammalian Limb

(Submitter supplied) Sonic hedgehog (Shh) signals via Gli transcription factors to direct digit number and identity in the vertebrate limb. We have characterized the Gli-dependent cis-regulatory network through a combination of whole genome ChIP-on-chip and transcriptional profiling of the developing mouse limb. These analyses identified approximately 5,000 high quality Gli3 binding sites, including all known Gli-dependent enhancers. more...

Organism:: Mus musculus

Type:: Expression profiling by array

9 related Platforms
43 Samples

Download data: BAR, CEL

Series

Accession:: GSE11077

ID:: 200011077

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000110635.

Expression data from E11.5 mouse embryonic forelimbs - various mutant conditions or dissected limb domains

(Submitter supplied) Sonic hedgehog (Shh) signals via Gli transcription factors to direct digit number and identity in the vertebrate limb. We have characterized the Gli-dependent cis-regulatory network through a combination of whole genome ChIP-on-chip and transcriptional profiling of the developing mouse limb. In this dataset, we include the expression data obtained from dissected mouse forelimbs using a variety of gain- and loss-of-function hedgehog pathway mutants, as well as limbs dissected into responsive (posterior 2/3ds) and non-responsive (anterior 1/3d) Hh tissues. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6096
28 Samples

Download data: CEL

Series

Accession:: GSE11063

ID:: 200011063

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000110626.

Genome-Wide Gli3 Binding Sites in the E11.5 Mouse Limb Bud

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array

8 related Platforms
15 Samples

Download data: BAR, BED, CEL

Series

Accession:: GSE11062

ID:: 200011062

PubMed Full text in PMC Similar studies

Select item 2000425947.

cis-Regulation of Shh-directed neural pattering

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

4 related Platforms
16 Samples

Download data: BED, CEL, TSV

Series

Accession:: GSE42594

ID:: 200042594

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000425658.

Transcriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors

(Submitter supplied) The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE42565

ID:: 200042565

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000421329.

ChIP-seq analysis of Gli1 and Sox2 input to neural progenitor program and integration with actve histone marks

(Submitter supplied) In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentration-dependent induction of six different cell populations mediated through Gli transcriptional regulators. Elsewhere in the embryo, Shh/Gli responses invoke different tissue appropriate regulatory programs. To elucidate Shh/Gli regulation of neural fate sepcification, we performed Gli1 ChIP-Seq analysis. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9250 GPL9185 GPL13112
10 Samples

Download data: BED, TSV

Series

Accession:: GSE42132

ID:: 200042132

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005866410.

RNA sequencing of cultured mouse wild-type E10.25 forelimbs in control or cyclopmaine containing media [SOLiD]

(Submitter supplied) We wanted to identify differentially expressed genes in wild-type forelimbs and forelimbs briefly exposed to Shh signaling. E10.25 forelimbs were cultured in control media and media containing cyclopmaine (inhibits the Hedgehog pathway)

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9318
4 Samples

Download data: CSV, TXT

Series

Accession:: GSE58664

ID:: 200058664

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005864511.

RNA sequencing of mouse littermate wild-type and Shh null E10.5 forelimbs [Illumina]

(Submitter supplied) We wanted to identify differentially expressed genes in wild-type and Shh null E10.5 mouse forelimbs

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: CSV, TXT

Series

Accession:: GSE58645

ID:: 200058645

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005822212.

Spatiotemporal regulation of GLI target genes in the mammalian limb bud

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL9318 GPL13112
8 Samples

Download data

Series

Accession:: GSE58222

ID:: 200058222

PubMed Full text in PMC Similar studies

Select item 20006546213.

Nkx2.2, Nkx6.1, Olig2, and Gli3 genomic binding regions and overexpression in neural progenitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL9250 GPL19057
28 Samples

Download data: BED

Series

Accession:: GSE65462

ID:: 200065462

PubMed Full text in PMC Similar studies

Select item 20006545714.

mRNAseq analysis of Nkx2.2, Nkx6.1, and Olig2 overexpression in neural progenitors

(Submitter supplied) Nkx2.2, Nkx6.1, and Olig2 repressors were overexpressed, singly or in combination, in in vitro-derived mouse neural progenitors to identify thier repression targets

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
15 Samples

Download data: XLSX

Series

Accession:: GSE65457

ID:: 200065457

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006167315.

Nkx2.2, Nkx6.1, Olig2, and Gli3 genomic binding regions in neural progenitors [ChIP-Seq]

(Submitter supplied) Nkx2.2, Nkx6.1, and Olig2 are transcriptional repressors regulating somatic motor neuron and interneuron subtypes in neural progenitors. The purpose of this study was to identify their target genes and to elucidate their gene regulatory mechanisms, including their relationship to Sonic Hedgehog/Gli pathway.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL13112 GPL9250
13 Samples

Download data: BED, TXT

Series

Accession:: GSE61673

ID:: 200061673

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001771916.

Gli1 regulatory networks in granule neuron precursor and medulloblastoma cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL6096 GPL5811
10 Samples

Download data: BAR, BED, CEL

Series

Accession:: GSE17719

ID:: 200017719

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001770217.

Gene expression profiles of murine granule neuron precursors and medulloblastoma

(Submitter supplied) Sonic hedgehog (Shh) signals via Gli transcription factors to stimulate proliferation of granule neuron precursor cells (GNPs) in the cerebellum. Deregulation of Shh target genes often results in unrestrained GNP proliferation and eventually medulloblastoma (MB), the most common pediatric brain malignancy. Gene expression profiling was coupled with transcription factor binding location analysis to determine the Gli1-controlled transcriptional regulatory networks in GNPs and medulloblastoma cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6096
8 Samples

Download data: CEL

Series

Accession:: GSE17702

ID:: 200017702

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001768218.

Chromatin localization of Gli1 in granule neuron precursor cells and medulloblastoma

(Submitter supplied) Sonic hedgehog (Shh) signals via Gli transcription factors to stimulate proliferation of granule neuron precursor cells (GNPs) in the cerebellum. Deregulation of Shh target genes often results in unrestrained GNP proliferation and eventually medulloblastoma, the most common pediatric brain malignancy. Transcription factor binding location analysis (chIP-chip) revealed 510 and 1,060 genomic loci bound by Gli1 with high confidence in murine GNP and medulloblastoma cells, respectively. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL5811
2 Samples

Download data: BAR, BED, CEL

Series

Accession:: GSE17682

ID:: 200017682

PubMed Full text in PMC Similar studies

Select item 20011464019.

Mouse embryonic stem cells (mESCs) differentiation towards ventral hindbrain neuronal cell types [d4.5, d5.5 and d6.5]

(Submitter supplied) mESCs treated with retinoic acid (RA) and a Shh agonist (SAG) recapitulated ventral hindbrain development and produced a population of neural progenitors with a minor presence of other cell types.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
9 Samples

Download data: TXT

Series

Accession:: GSE114640

ID:: 200114640

PubMed Full text in PMC Similar studies SRA Run Selector

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