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Links from GEO DataSets

Items: 19

1.
Full record GDS2696

Teratozoospermia (Human-6 BeadChip)

Analysis of sperm cells from males with consistent and severe teratozoospermia, a condition in which less than 4 percent of sperm cells are morphologically normal. Results provide insight into the molecular basis of a range of teratozoospermic presentations.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL2507
Series:
GSE6967
13 Samples
Download data: TXT
DataSet
Accession:
GDS2696
ID:
2696
2.

Spermatozoal RNA Profiles from Normally Fertile and Heterogeneously Teratozoospermic Subjects

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL2507 GPL570 GPL2700
44 Samples
Download data: CEL, TXT
Series
Accession:
GSE6969
ID:
200006969
3.

Spermatozoal RNA Profiles (HumanRef-8 BeadChip)

(Submitter supplied) Normal human spermatogenesis concludes with the formation of large numbers of morphologically well developed spermatozoa. While transcriptionally quiescent these cells carry an RNA payload that reflects the final spermiogenic phase of transcription. We report here the spermatozoal transcript profiles characteristic of normally fertile individuals and infertile males suffering from a consistent and severe teratozoospermia in which under 4% of spermatozoa are morphologically normal. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2695
Platform:
GPL2700
10 Samples
Download data: TXT
Series
Accession:
GSE6968
ID:
200006968
4.

Spermatozoal RNA Profiles (Human-6 BeadChip)

(Submitter supplied) Normal human spermatogenesis concludes with the formation of large numbers of morphologically well developed spermatozoa. While transcriptionally quiescent these cells carry an RNA payload that reflects the final spermiogenic phase of transcription. We report here the spermatozoal transcript profiles characteristic of normally fertile individuals and infertile males suffering from a consistent and severe teratozoospermia in which under 4% of spermatozoa are morphologically normal. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2696
Platform:
GPL2507
13 Samples
Download data: TXT
Series
Accession:
GSE6967
ID:
200006967
5.

Spermatozoal RNA Profiles (U133 Plus 2.0 Array)

(Submitter supplied) Normal human spermatogenesis concludes with the formation of large numbers of morphologically well developed spermatozoa. While transcriptionally quiescent these cells carry an RNA payload that reflects the final spermiogenic phase of transcription. We report here the spermatozoal transcript profiles characteristic of normally fertile individuals and infertile males suffering from a consistent and severe teratozoospermia in which under 4% of spermatozoa are morphologically normal. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2697
Platform:
GPL570
21 Samples
Download data: CEL
Series
Accession:
GSE6872
ID:
200006872
6.
Full record GDS2697

Teratozoospermia (HG-U133 2.0 )

Analysis of sperm cells from males with consistent and severe teratozoospermia, a condition in which less than 4 percent of sperm cells are morphologically normal. Results provide insight into the molecular basis of a range of teratozoospermic presentations.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE6872
21 Samples
Download data: CEL
DataSet
Accession:
GDS2697
ID:
2697
7.
Full record GDS2695

Teratozoospermia (HumanRef-8 BeadChip)

Analysis of sperm cells from males with consistent and severe teratozoospermia, a condition in which less than 4 percent of sperm cells are morphologically normal. Results provide insight into the molecular basis of a range of teratozoospermic presentations.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL2700
Series:
GSE6968
10 Samples
Download data: TXT
DataSet
Accession:
GDS2695
ID:
2695
8.

rRNA cleavage ensures translational cessation in the mature sperm

(Submitter supplied) We report how unique RNA seq profiles of ribosomal RNA (18S, 28S) present in sperm indicate specific cleavage sites. Additionally, these sequencing results reveal how overall character of RNA (GC content) can significantly affect overall distribution of mapped reads.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL10999
6 Samples
Download data: TXT
9.

Characterization of the small RNA population in Human spermatozoa

(Submitter supplied) Small noncoding RNAs (sncRNA) are becoming recognized for their participation in a diverse range of cellular functions. In this study, their global characterization in human spermatozoa from donors with proven fertility was undertaken. Reads were analyzed in two classes, those mapping to unique locations and those that could be aligned to up to 10 genomic locations. All libraries showed comparable distribution of reads between intergenic, intronic and exonic genomic regions. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL9115
3 Samples
Download data: TXT
Series
Accession:
GSE21191
ID:
200021191
10.

Expression of Mouse and Human Sense-Antisense Transcript

(Submitter supplied) Increasing numbers of sense–antisense transcripts (SATs), which are transcribed from the same chromosomal location but in opposite directions, have been identified in various eukaryotic species, but the biological meanings of most SATs remain unclear. To improve understanding of natural sense–antisense transcription, we performed comparative expression profiling of SATs conserved among humans and mice. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6119 GPL6120
20 Samples
Download data
Series
Accession:
GSE9581
ID:
200009581
11.

Comparison of human epididymal gene expression in the caput epididymides of infertile and fertile patients

(Submitter supplied) Caput epididymides biopsies from 4 patients suffering from non-obstructive azoospermia and from 4 patients with active spermatogenesis were compared. 414 genes in the caput epididymides were differentially regulated in infertile men by at least a 2-fold change as compared to the fertile men. Keywords: Comparison of infertile and fertile caput epididymides
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
5 Samples
Download data: GPR
Series
Accession:
GSE9194
ID:
200009194
12.

Use of spermatozoal total RNA profiles to study gene-environment interactions in human germ cells

(Submitter supplied) Paternal exposure to genotoxic compounds is thought to contribute to diseases in their offspring. Therefore, mRNA profiles from sperm in ejaculates of cigarette smokers (N=4) were compared with non-smokers (N=4). Smoking behaviour was verified by assessing cotinine levels in seminal plasma. Gene-expression analysis was subsequently performed using microarray technology (Agilent human 4x44k) to investigate the use of gene-expression profiling as biomarker of gene-environment interactions in human testis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
8 Samples
Download data: TXT
Series
Accession:
GSE13600
ID:
200013600
13.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
14.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
15.

Stallion sperm transcriptome as revealed by microarray analysis and RNA sequencing

(Submitter supplied) Purpose: In order to understand the functional significance of sperm transcriptome in stallion fertility, the aim of this study was to generate a detailed body of knowledge about the sperm RNA profile that defines a normal fertile stallion. Methods: The 50 bp single-end ABI SOLiD raw reads were directly aligned with the horse reference sequence EcuCab2 using ABI aligner software (NovoalignCS version 1.00.09, novocraft.com) which uses multiple indexes in the reference genome, identifies candidate alignment locations for each primary read, and allows completion of the alignment. more...
Organism:
Equus caballus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15696
2 Samples
Download data: TXT
Series
Accession:
GSE38725
ID:
200038725
16.

Region specific gene expression profiling along the human epididymis

(Submitter supplied) Analysis of the gene expression pattern in the caput, corpus and cauda epididymides of three donors of 26-50 years of age with no medical pathologies that could affect reproductive function. The data generated in this study demonstrate a region specific gene expression pattern along the human epididymis that seems to coincide with the morphological distinctive features of the excurrent duct. Keywords: Tissue compartements comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
9 Samples
Download data: CEL
Series
Accession:
GSE7808
ID:
200007808
17.

Stability, Delivery and Functions of Human Sperm RNAs at Fertilization

(Submitter supplied) We report on abundance and transcript profile characteristics of sperm RNAs.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9115
5 Samples
Download data: BED
18.

Spermatozoal mRNA is reproducibly detected in purified D. melanogaster sperm.

(Submitter supplied) It is now well established that mature mammalian spermatozoa carry a population of mRNA molecules, at least some of which are transferred to the oocyte at fertilisation. However, the function of the sperm transcriptome remains largely unclear. To shed light on the evolutionary conservation of this feature of sperm biology, we analysed highly purified populations of mature sperm from the fruitfly, Drosophila melanogaster. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Platform:
GPL14121
10 Samples
Download data
Series
Accession:
GSE33947
ID:
200033947
19.

The Transcript Integrity Index (TII) provides a standard measure of sperm RNA

(Submitter supplied) Human sperm RNA-seq was performed and sequences used for the generation of a RNA integrity index capable of assessing samples with high RNA fragmentation. A two-prong approach was used including both manual and computational analysis. This identified a series of sperm RNAs that are consistently intact, and acceptable for use in determining sample RNA quality. These RNAs function in roles related to spermatogenesis and/or fertilization.
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL20301 GPL18573
40 Samples
Download data: TXT
Series
Accession:
GSE201081
ID:
200201081
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