GEO DataSets

Analysis of preinvasive ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) tumors. Pairs of patient-matched DCIS and IDC tumor specimens analyzed. Results provide insight into the mechanisms underlying the progression of DCIS to IDC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 7 individual sets

Platform:

GPL570

Series:

GSE3893

14 Samples

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(Submitter supplied) This is a matched-pair analysis of ductal carcinoma in situ (DCIS) and invasive component (IDC) of nine breast ductal carcinoma to identify novel molecular markers characterizing the transition from DCIS to IDC for a better understanding of its molecular biology. Keywords: Affymetrix-based Microarrays in Mamma carcinoma

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2045 GDS2046

Platforms:

GPL570 GPL96

24 Samples

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Analysis of preinvasive ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) tumors. Pairs of patient-matched DCIS and IDC tumor specimens analyzed. Results provide insight into the mechanisms underlying the progression of DCIS to IDC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 5 individual sets

Platform:

GPL96

Series:

GSE3893

10 Samples

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(Submitter supplied) To obtain insight into the molecular basis of ductal carcinoma in situ (DCIS) and its progression by infiltrating surrounding tissue, we have performed cellular-based gene expression analysis of pure DCIS and DCIS with co-existing invasive ductal carcinoma (IDC) and compared the histological and molecular aspects between these morphologically identical lesions seeking to find key genes involved in DCIS progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1930

60 Samples

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(Submitter supplied) cDNA aCGH study of pure DCIS (breast duct carcinoma in situ) without invasive tumor, DCIS associated with IDC (breast invasive duct carcinoma) and its IDC component 23 patients: 6 pure DCIS without invasive cancer and no history of invasive cancer, 17 DCIS associated with IDC. Out of the latter 1 tumor had only enough DCIS (#16) for aCGH and one - IDC (#23) Keywords: Comparative clinical study

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL6382

38 Samples

Download data: GPR, TXT

(Submitter supplied) Analysis of gene expression changes in tumour epithelium (DCIS and invasive breast cancer) and stroma both immediately surrounding the lesions and more distantly.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6883

67 Samples

Download data: TXT

(Submitter supplied) Microarray is widely used to monitor gene expression changes in breast cancer. The transcriptomic changes in breast cancer is commonly occured during the transition of normal cells to cancerous cells. This is the first study on gene expression profiling of multi ethnic of Malaysian breast cancer patients (Malays, Chinese and Indian). We aim to identify differentially expressed genes between tumors and normal tissues. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

86 Samples

Download data: CEL, CHP

(Submitter supplied) Whole-genome BAC-array. Isolated BAC-DNA was amplified by two-step DOP-PCR. PCR products were dissolved in 3xSSC, 1.5M betaine and spotted as triplicates on epoxysilane-coated slides. Keywords = Matrix-CGH Keywords = array-CGH

Organism:

Homo sapiens

1 Series

94 Samples

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(Submitter supplied) we describe a mRNA profiling analysis of matched ductal carcinoma in situ and invasive duct carcinoma components of FFPE breast carcinomas with the purpose to identify potential prognostic markers

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8432

42 Samples

Download data: TXT

(Submitter supplied) Case-control study for the analysis of the gene expression profile of epithelial cells microdissected from normal breast tissues obtained from 17 parous and 7 nulliparous women free of breast pathology (controls), and 39 parous and 8 nulliparous women with history of breast cancer (cases). Keywords: genetic modifications

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL7384 GPL7392 GPL7393

210 Samples

Download data: TXT

(Submitter supplied) The aim of our study was to identify gene expression profiles of ductal and lobular carcinomas in relation to normal ductal and lobular cells. We examined ten mastectomy specimens from postmenopausal breast cancer patients. Ductal and lobular tumor and normal cells were microdissected from cryosections. Fifty nanograms of total RNA were amplified and labeled by PCR and in vitro transcription. GCOS pairwise comparison algorithm and rank products have identified multiple genes that are differentially expressed in comparisons between ductal and lobular tumor and normal cell types. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2635

Platform:

GPL570

30 Samples

Download data: CEL, EXP

Analysis of invasive ductal carcinoma (IDC) cells, invasive lobular carcinoma (ILC) cells, and their normal counterparts. Cells obtained from postmenopausal breast cancer patients. Results provide insight into the molecular differences between IDC and ILC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 disease state sets

Platform:

GPL570

Series:

GSE5764

30 Samples

Download data: CEL, EXP

(Submitter supplied) Fresh Atypical ductal hyperplasia (ADH) tissue collected from breast of a women who either (1) had no prior history of breast cancer and had not developed breast cancer in five years after diagnosis, (2) had cancer before ADH, or had cancer at the time as ADH or developed cancer after ADH diagnosis Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1250

Platform:

GPL96

8 Samples

Download data: CEL, CHP

Comparison of atypical ductal hyperplasia (ADH) tissues from patients with and without a history of breast cancer. Incidence of invasive breast cancer is high in ADH patients. Results identify putative markers of invasive breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL96

Series:

GSE2429

8 Samples

Download data: CEL, CHP

(Submitter supplied) Tumor tissue heterogeneity is a well known feature of several solid tumors. Neuroblastic Tumors (NTs) is a group of paediatric cancers with a great tissue heterogeneity. Most of NTs are composed of undifferentiated, poorly differentiated or differentiating neuroblastic (Nb) cells with very few or absent Schwannian stromal (SS) cells: these tumors are grouped as Neuroblastoma (Schwannian stroma-poor). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

28 Samples

Download data: CEL

(Submitter supplied) Background. The development of reliable gene expression profiling technology is having an increasing impact on our understanding of breast cancer biology. Methods. In this study, microarray analysis was performed in order to establish gene signatures for different breast cancer phenotypes, determine differentially expressed gene sequences at different stages of the disease, and identify sequences with biological significance for tumor progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

58 Samples

Download data: CEL, TXT

(Submitter supplied) Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive ductal carcinoma (IDC). Annotation of the genetic differences between the two lesions may assist in the identification of genes that promote the invasive phenotype. Matched IDC and DCIS showed highly similar copy number profiles (average of 83% of the genome shared) indicating a common clonal orgin although there is evidence that the DCIS continues to evolve in parallel with the co-existing IDC. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL13270

42 Samples

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(Submitter supplied) Exonic profiling is an emerging topic in disease-associated transcriptome analysis, but is still facing major limitations. In this study, we performed a microarray-based analysis of the transcriptome at the exon level of mouse primary mammary tumors having different abilities to give rise to metastases. First, we developed a bioinformatics platform and used a stringent algorithm to identify 679 genes with differentially expressed exons in primary tumors of the 4T1 mouse model of mammary tumor progression. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6193

12 Samples

Download data: CEL

(Submitter supplied) Transcriptomic analysis of fresh breast cancer tissue versus normal tissues. The Study comprising 45 Saudi-Arabian subjects was designed to take advantage of transcriptomics to prospectively explore the roles of lifestyle and genetic susceptibility in the occurrence of breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

50 Samples

Download data: CEL, TXT

(Submitter supplied) To better understand the role of tumor microenvironment in breast cancer progression, we combined laser capture microdissection and microarray analysis to provide a comprehensive catalog of gene expression changes in both tumor and tumor-associated stroma. Keywords: cancer vs. normal

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1352

66 Samples

Download data: CEL