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Links from GEO DataSets

Items: 20

1.

KRYPTONITE shapes TAD-like boundaries through the control of H3K9ac [Hi-C]

(Submitter supplied) Employing high-throughput sequencing and advanced microscopy techniques, we explored twenty-six histone modifications and Pol II distribution landscape in tomato (Solanum lycopersicum). Our findings revealed a comprehensive epigenetic landscape, uncovering distinct chromatin states associated with heterochromatin formation and gene silencing, allowing for the classification of genomic regions.
Organism:
Solanum lycopersicum
Type:
Other
Platform:
GPL21762
5 Samples
Download data: TXT
Series
Accession:
GSE245527
ID:
200245527
2.

KRYPTONITE shapes TAD-like boundaries through the control of H3K9ac [ChIP-Seq]

(Submitter supplied) Employing high-throughput sequencing and advanced microscopy techniques, we explored twenty-six histone modifications and Pol II distribution landscape in tomato (Solanum lycopersicum). Our findings revealed a comprehensive epigenetic landscape, uncovering distinct chromatin states associated with heterochromatin formation and gene silencing, allowing for the classification of genomic regions.
Organism:
Solanum lycopersicum
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21762
8 Samples
Download data: BIGWIG
Series
Accession:
GSE264430
ID:
200264430
3.

KRYPTONITE shapes TAD-like boundaries through the control of H3K9ac [ATAC-Seq]

(Submitter supplied) Employing high-throughput sequencing and advanced microscopy techniques, we explored twenty-six histone modifications and Pol II distribution landscape in tomato (Solanum lycopersicum). Our findings revealed a comprehensive epigenetic landscape, uncovering distinct chromatin states associated with heterochromatin formation and gene silencing, allowing for the classification of genomic regions.
Organism:
Solanum lycopersicum
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21762
4 Samples
Download data: BIGWIG
Series
Accession:
GSE264429
ID:
200264429
4.

KRYPTONITE shapes TAD-like boundaries through the control of H3K9ac

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Solanum lycopersicum
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
Platforms:
GPL27957 GPL21762
51 Samples
Download data: BIGWIG, BROADPEAK, NARROWPEAK
Series
Accession:
GSE245529
ID:
200245529
5.

KRYPTONITE shapes TAD-like boundaries through the control of H3K9ac [RNA-seq]

(Submitter supplied) Employing high-throughput sequencing and advanced microscopy techniques, we explored twenty-six histone modifications and Pol II distribution landscape in tomato (Solanum lycopersicum). Our findings revealed a comprehensive epigenetic landscape, uncovering distinct chromatin states associated with heterochromatin formation and gene silencing, allowing for the classification of genomic regions.
Organism:
Solanum lycopersicum
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27957
6 Samples
Download data: TXT
Series
Accession:
GSE245528
ID:
200245528
6.

KRYPTONITE shapes TAD-like boundaries through the control of H3K9ac [ChIP-seq]

(Submitter supplied) Employing high-throughput sequencing and advanced microscopy techniques, we explored twenty-six histone modifications and Pol II distribution landscape in tomato (Solanum lycopersicum). Our findings revealed a comprehensive epigenetic landscape, uncovering distinct chromatin states associated with heterochromatin formation and gene silencing, allowing for the classification of genomic regions.
Organism:
Solanum lycopersicum
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21762
28 Samples
Download data: BIGWIG, BROADPEAK, NARROWPEAK
Series
Accession:
GSE245525
ID:
200245525
7.

Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL17275
19 Samples
Download data: TXT
Series
Accession:
GSE126952
ID:
200126952
8.

Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes [5C]

(Submitter supplied) Transcription of genes residing within constitutive heterochromatin is paradoxical to the tenets of epigenetic code. Regulatory mechanisms of Drosophila melanogaster heterochromatic gene transcription remain largely unknown. We investigated the contribution of pericentromeric genome organization and heterochromatic factors in orchestrating heterochromatic gene expression. Using 5C-seq, we characterized the pericentromeric TADs in Drosophila melanogaster. more...
Organism:
Drosophila melanogaster
Type:
Other
Platform:
GPL17275
10 Samples
Download data: TXT
Series
Accession:
GSE126951
ID:
200126951
9.

Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes [RNA-seq]

(Submitter supplied) Transcription of genes residing within constitutive heterochromatin is paradoxical to the tenets of epigenetic code. Regulatory mechanisms of Drosophila melanogaster heterochromatic gene transcription remain largely unknown. We investigated the contribution of pericentromeric genome organization and heterochromatic factors in orchestrating heterochromatic gene expression. Using 5C-seq, we characterized the pericentromeric TADs in Drosophila melanogaster. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17275
9 Samples
Download data: TSV, TXT
Series
Accession:
GSE126950
ID:
200126950
10.

Local compartment changes and regulatory landscape alterations in histone H1-depleted cells

(Submitter supplied) Linker histone H1 is a core chromatin component that binds to nucleosome core particles and the linker DNA between nucleosomes. It has been implicated in chromatin compaction and gene regulation and is anticipated to play a role in higher-order genome structure. We find that depletion of histone H1 changes the epigenetic signature of thousands of potential regulatory sites across the genome. Many of them show cooperative loss or gain of multiple chromatin marks. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
4 related Platforms
41 Samples
Download data: BED, TXT
Series
Accession:
GSE75426
ID:
200075426
11.

Chromatin Loops Associated with Active Genes and Heterochromatin Shape Rice Genome Architecture for Transcriptional Regulation

(Submitter supplied) We systematically analyze the basic features of chromatin interaction mediated by RNAP2, H3K4me3 and H3K9me2. All interactions further aggregated into higher-order clusters and modular interacting domains with distinct genomic and transcriptional properties. Together, our strategy provides hierarchical and modular 3D genome architecture for transcription regulation in rice.
Organism:
Oryza sativa Indica Group
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL26667
12 Samples
Download data: BED
Series
Accession:
GSE131202
ID:
200131202
12.

Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL16791 GPL11154
22 Samples
Download data: BED
Series
Accession:
GSE73785
ID:
200073785
13.

Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations [RNA-seq]

(Submitter supplied) A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. Here, we perform HiC chromosome conformation, ChIP-seq and RNA-seq to investigate how the three-dimensional organization of the cancer genome is disrupted in the context of epigenetic remodelling and atypical gene expression programs.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TSV
14.

Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations [ChIP-seq]

(Submitter supplied) A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. Here, we perform HiC chromosome conformation, ChIP-seq and RNA-seq to investigate how the three-dimensional organization of the cancer genome is disrupted in the context of epigenetic remodelling and atypical gene expression programs.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
3 Samples
Download data: BED
Series
Accession:
GSE73783
ID:
200073783
15.

Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations [Hi-C]

(Submitter supplied) A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. Here, we perform Hi-C chromosome conformation to investigate how the three-dimensional organization of the cancer genome is disrupted in the context of epigenetic remodelling and atypical gene expression programs.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL16791
13 Samples
Download data: BED, TXT
Series
Accession:
GSE73782
ID:
200073782
16.

Analysis of the DNA topology in T47D-MTVL cells by Hi-C data

(Submitter supplied) The topology of the genome in untreated T47D-MTVL cells expressing a Dox-inducible shRNA against multiple H1 variants was analyzed by performing a Hi-C experiment. The data allowed the obtention of Hi-C chromosome interaction maps, which were used to define TADs and A/B compartments, and to study the relationship between the 3D genome in breast cancer cells and other genomic properties as well as the histone H1 variants genome-wide distribution.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL16791
1 Sample
Download data: BED, BEDGRAPH
Series
Accession:
GSE147627
ID:
200147627
17.

Replication timing in Suz12 knockout ESCs

(Submitter supplied) We profiled replication timing in Suz12 knockout ESCs and observed no differences relative to wild-type controls.
Organism:
Mus musculus
Type:
Genome variation profiling by genome tiling array
Platform:
GPL11620
2 Samples
Download data: PAIR
Series
Accession:
GSE55416
ID:
200055416
18.

DNA replication-timing boundaries separate stable chromosome domains with cell-type-specific functions

(Submitter supplied) Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains;), whose positions are preserved in different cell types, conserved between species, and appear to confine long-range effects of chromosome rearrangements. more...
Organism:
Homo sapiens; Mus musculus
Type:
Other
25 related Platforms
993 Samples
Download data: BAM, BED, BIGWIG, BROADPEAK, NARROWPEAK, PAIR, TSV, TXT
Series
Accession:
GSE51334
ID:
200051334
19.

Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of P. falciparum

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Plasmodium falciparum
Type:
Genome binding/occupancy profiling by genome tiling array; Expression profiling by genome tiling array
Platform:
GPL8456
18 Samples
Download data: PAIR
Series
Accession:
GSE16096
ID:
200016096
20.

Mapping of H3, H3K4me3 and H3K9ac on Ring and Schizont stages of P. falciparum

(Submitter supplied) Epigenome profiling has led to the paradigm that promoters of active genes are decorated with H3K4me3 and H3K9ac marks. These data on synchronized parasites reveals significant developmental stage specificity of the epigenome. In rings, H3K4me3 and H3K9ac are homogenous across the genes marking active and inactive genes equally, whilst in schizonts they are enriched at the 5’end of active genes.
Organism:
Plasmodium falciparum
Type:
Genome binding/occupancy profiling by genome tiling array; Expression profiling by genome tiling array
Platform:
GPL8456
8 Samples
Download data: PAIR
Series
Accession:
GSE16095
ID:
200016095
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