Similar studies for GEO DataSets (Select 200183603) - GEO DataSets

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Items: 3

Select item 2001836031.

Gene expression in commercial human cerebral microvascular endothelial cells (hCMECs) line knock out or not for RNF213

(Submitter supplied) To study the role of RNF213, we generated RNF213-deficient human cerebral microvascular endothelial cells by the CRISPR-Cas9 double nickase method and showed that RNF213 may be an important regulator of the blood-brain barrier permeability and homeostasis

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13607
14 Samples

Download data: TXT, XLSX

Series

Accession:: GSE183603

ID:: 200183603

Select item 2000623482.

Gene expression profile in HCAECs transfected with RNF213 siRNA

(Submitter supplied) We performed transcriptome analysis of HCAECs upon treatment with siRNF213 or with a control siRNA. Overall, a total of 217 genes were up-regulated (> 2.0-fold change in expression), while 499 genes were down-regulated (< 0.5-fold change in expression), in the siRNF213-treated cells when compared to the control. Expression of four genes (RNF213, CyclinA, B and E) from this signature was quantified in the same RNA samples by real-time PCR.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
4 Samples

Download data: TXT

Series

Accession:: GSE62348

ID:: 200062348

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Select item 2001687213.

RNF213-associated urticarial lesions with hypercytokinemia

(Submitter supplied) Urticarial lesions are observed in both cutaneous and systemic disorders. Familial forms of urticarial syndromes are rare and can be encountered in systemic auto-inflammatory diseases. We investigated a large family with dominantly inherited chronic urticarial lesions associated with hypercytokinemia. We performed a genetic linkage analysis in 14 patients from a 5-generation family, as well as whole-exome sequencing, cytokine profiling and transcriptomic analyses on samples from two patients. more...