GEO DataSets

(Submitter supplied) We analyzed RNA-seq data from C. elegans on six bacterial diets, 3 E. coli diets (OP50, HT115, HB101) found in the laboratory setting and 3 found in C. elegans natural environment (Methylobacterium, Xanthomonas, Sphingomonas). We compared gene expression between L4 worms on the OP50 diet to the other 5 bacterial diets. We found that diet influences many gene expression changes, leading to genes being both up regulated and down regulated in a diet-dependent manner.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26672

24 Samples

Download data: TXT

(Submitter supplied) In the present study, we investigated the effect of CBM 588 on lifespan and multiple-stress resistance using Caenorhabditis elegans as a model animal. When adult C. elegans were fed a standard diet of Escherichia coli OP50 or CBM 588, the lifespan of the animals fed CBM 588 was significantly longer than that of animals fed OP50. Moreover, the worms fed CBM 588 were more resistant to certain stressors, including infections with pathogenic bacteria, UV irradiation, and the metal stressor Cu2+. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13657

2 Samples

Download data: TXT

(Submitter supplied) Numerous studies have shown that resistance to oxidative stress is crucial to stay healthy and to reduce the adverse effects of aging. Accordingly, nutritional interventions using antioxidant food-grade compounds or food products are currently an interesting option to help improve health and quality of life in the elderly. Live lactic acid bacteria (LAB) administered in food, such as probiotics, may be good antioxidant candidates. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Datasets:

GDS4566 GDS5006

Platform:

GPL200

18 Samples

Download data: CEL

Analysis of adult worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 10 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL200

Series:

GSE42192

9 Samples

Download data: CEL

Analysis of young worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 3 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL200

Series:

GSE42192

9 Samples

Download data: CEL

(Submitter supplied) These three arrays are replicate extractions and hybridizations. Each array hybridizes labeled RNA from NGM plate grown, mixed stage, animals (Channel 1) against labled RNA from liquid CeMM grown, mixed stage, animals (Channel 2). A replicate experimental design type is where a series of replicates are performed to evaluate reproducibility or as a pilot study to determine the appropriate number of replicates for a subsequent experiments. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL3411

3 Samples

Download data

(Submitter supplied) We report here that in C. elegans, indole induces a gene expression profile in aged animals reminiscent of that seen in the young, but which is distinct from that associated with normal aging. Moreover, in older animals, indole induces genes associated with oogenesis, and, accordingly, extends fecundity and reproductive span.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13657

11 Samples

Download data: CSV, TXT

(Submitter supplied) Aging is a major international concern and brings with it formidable socioeconomical and healthcare challenges. An attainable approach to improve general health in humans is using small molecules. Tomatidine, a natural compound abundant in unripe tomatoes, inhibits aging-related skeletal muscle atrophy in mice. Here we show that tomatidine extends lifespan and healthspan in the aging animal model C. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL10094

7 Samples

Download data: TXT

(Submitter supplied) We confirmed that the life span of C. elegans feeding hns mutant E. coli was increased. hns mutant E. coli was found to regulate lifespan of C. elegans through daf-16 activation in C. elegans. It is well known that daf-16 is the transcription factor of the insulin/IGF-1 signaling pathway and it is known to regulate downstream genes such as longevity, stress response, and dauer diapause regulation genes. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19757

8 Samples

Download data: TXT

(Submitter supplied) One of the most important issues in the study of aging is to discover compounds with longevity-promoting activity and to unravel their underlying mechanisms. Queen honey bees are continuously fed royal jelly (RJ), and they live more than 10 times longer than hive workers, derived from the same diploid genome, which are fed it only for a short period of time during their larval stages. Therefore, RJ is likely to contain longevity-promoting agents for queens. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL11346

6 Samples

Download data: TXT

(Submitter supplied) To understand the impact of a diet on host health, we performed a number of assays with C. elegans reared on OP50 or HT115 E. coli. We observed that HT115 provided a substantial increase in resistance to Liquid Killing and abiotic stresses (e.g., heat shock, oxidative stress). This phenomenon was independent of the worms’ innate immune system. In the absence of any other obvious candidates, we turned to microarray transcriptional profiling to gain an unbiased picture of the differences that result from feeding C. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

6 Samples

Download data: CEL