Similar studies for GEO DataSets (Select 200143482) - GEO DataSets

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Items: 15

Select item 2001434821.

Comparison of the LIGHT and TGF-B1 induced transcriptomes in esophageal FBL

(Submitter supplied) To understand the transcriptional responses induced by LIGHT in esophageal fibroblasts and compare them to the pro-fibrotic TGF-B1

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TSV

Series

Accession:: GSE143482

ID:: 200143482

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001566512.

Conserved interferon signature between adult and pediatric eosinophilic esophagitis

(Submitter supplied) Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus that occurs in both children and adults. Previous studies of affected tissue in pediatric cohorts have identified prominent signatures of eosinophilia and type 2 inflammation. However, the details of the immune response in adults with EoE are still being elucidated. To determine whether EoE in adults shares inflammatory profiles with those observed in children, we performed RNA-sequencing of paired esophageal biopsies and blood samples from adults with EoE or gastroesophageal reflux disease (GERD). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
20 Samples

Download data: CSV

Series

Accession:: GSE156651

ID:: 200156651

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Select item 2001133413.

Genome-wide expression from the esophageal biopsies of subjects with and without eosinophilic esophagitis

(Submitter supplied) Esophageal biopsy RNA was isolated from distal esophageal biopsy RNA from EoE patients with active disease and from unaffected controls. EoE biopsies showed active disease pathology at the time when they were taken, and all patients reported no glucocorticoid treatment at the time of biopsy. RNA sequencing acquiring 50 million mappable 125 base-pair reads from paired-end libraries was performed at the Genetic Variation and Gene Discovery Core Facility at Cincinnati Children's Hospital Medical Center. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
20 Samples

Download data: CSV

Series

Accession:: GSE113341

ID:: 200113341

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Select item 2000586404.

Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing

(Submitter supplied) We utilized RNA sequencing to expand and better define the molecular entities involved in the transcriptional programming within the eosphagus in eosinophilic esophagitis (EoE)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
16 Samples

Download data: TXT

Series

Accession:: GSE58640

ID:: 200058640

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001483815.

Genome wide expression from esophageal biopsies of subjects with EoE-like inflammatory diseases, eosinophilic esophagitis, gastroesophageal reflux disease and healthy controls

(Submitter supplied) Esophageal biopsy RNA was isolated from proximal esophageal biopsied RNA from patients with EoE-like inflammatory diseases (EoE-like esophagitis, lymphocytic esophagitis, non-specific esophagitis), patients with active EoE, patients with GERD, and unaffected healthy controls. EoE-like inflammatory disease patients were clinically active at the time when biopsies were taken. None of the patients (EoE-like inflammatory diseases, EoE, GERD and controls) were under anti-eosinophil treatment (including dietary restrictions). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
51 Samples

Download data: TXT, XLSX

Series

Accession:: GSE148381

ID:: 200148381

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Select item 2000557956.

MicroRNA assays of eosinophilic esophagitis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR; Other

Platforms:: GPL17853 GPL16142
21 Samples

Download data

Series

Accession:: GSE55795

ID:: 200055795

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000557947.

Nanostring nCounter human miRNA assay (v1) of eosinophilic esophagitis

(Submitter supplied) Nanostring nCounter Human miRNA assay (v1) of esophageal mucosal biopsies from children with eosinophilic esophagitis and controls

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16142
11 Samples

Download data: TXT

Series

Accession:: GSE55794

ID:: 200055794

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Select item 2000557938.

TaqMan microRNA array of human serum from children with eosinophilic esophagitis

(Submitter supplied) Serum from children with active and inactive treated eosinophilic esophagitis was analyzed for detection of microRNA

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL17853
10 Samples

Download data: TXT

Series

Accession:: GSE55793

ID:: 200055793

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000367279.

MicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Glucocorticoid Steroid Treatment and Relationship with mRNA Target Expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by RT-PCR

Platforms:: GPL6244 GPL13328
20 Samples

Download data: CEL

Series

Accession:: GSE36727

ID:: 200036727

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003672610.

miRNA Profiling in mucosal biopsies of Eosinophilic Esophagitis patients pre and post glucocorticoid steroid treatment

(Submitter supplied) Eosinophlic esophagitis (EoE) is increasely recognized as an antigen-drived disorder. The goal of this study is to reveal the miRNA expression changes in EoE before and after a successful glucocorticoid steroid treatment.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL13328
10 Samples

Download data: TXT

Series

Accession:: GSE36726

ID:: 200036726

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Select item 20003672511.

Gene profiling in mucosal biopsies of Eosinophilic Esophagitis patients pre and post glucocorticoid steroid treatment

(Submitter supplied) Eosinophlic esophagitis (EoE) is increasely recognized as an antigen-drived disorder. The goal of this study is to reveal the gene expression changes in EoE before and after a successful glucocorticoid steroid treatment. We used microarrays to identify distinct genes involving the pathophysiology of EoE.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
10 Samples

Download data: CEL

Series

Accession:: GSE36725

ID:: 200036725

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Select item 20024927612.

Amphiregulin-producing T helper 2 cells have critical role in esophageal fibrosis of EoE

(Submitter supplied) Background: Massive eosinophil infiltration into the esophagus causes subepithelial fibrosis and esophageal stricture in patients with eosinophilic esophagitis (EoE). However, the pathogenesis of esophageal fibrosis remains unclear. Objective: The present study aimed to elucidate the cellular and molecular mechanisms underlying the induction of esophageal fibrosis. Methods: We established a murine model of EoE accompanied by fibrotic responses following long-term intranasal administration of house dust mite (HDM) antigen. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL24247
12 Samples

Download data: MTX, TSV

Series

Accession:: GSE249276

ID:: 200249276

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Select item 20025608813.

Single cell RNA Squencing of Human Eosinophils in Allergc Inflammation in the Esophagus

(Submitter supplied) Eosinophils are elusive cells involved in allergic inflammation. Herein, we profiled 586 human eosinophils from the circulation and an allergic inflammatory site, the esophagus, of patients with eosinophilic esophagitis by Seq-Well–based single-cell RNA sequencing. The esophageal eosinophils were composed of a population of activated eosinophils (enriched in 659 genes compared with peripheral blood-associated eosinophils) and a small population of eosinophils resembling peripheral blood eosinophils (enriched in 62 genes compared with esophageal eosinophils). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE256088

ID:: 200256088

PubMed Similar studies

Select item 20021811814.

Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis

(Submitter supplied) Eosinophilic esophagitis and esophageal squamous cell carcinoma both feature epithelial remodeling in the form of hyperplasia. We used scRNA-Seq to examine the cellular and molecular alterations between these distinct pathologies.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
22 Samples

Download data: CSV

Series

Accession:: GSE218118

ID:: 200218118

PubMed Full text in PMC Similar studies

Select item 20017389515.

RNA-sequencing identifies global transcriptional changes in peripheral CD4+ cells during active esophagitis and following epicutaneous immunotherapy in eosinophilic esophagitis.

(Submitter supplied) Immunotherapy strategies have been studied for IgE-mediated food allergies but have not been studied for non-IgE mediated food allergy disorders, including eosinophilic esophagitis. We interrogated the transcriptional signatures of peripheral CD4+ cells isolated from pediatric eosinophilic esophagitis patients enrolled in a phase IIa clinical trial of milk-antigen epicutaneous immunotherapy. We analyzed differential expression in peripheral CD4+ cells before therapy in patients before and after milk-exclusion diet. more...