Similar studies for GEO DataSets (Select 200140858) - GEO DataSets

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Items: 17

Select item 2001408581.

BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene

(Submitter supplied) Oral squamous cell carcinoma (OSCC) has increased morbidity, and its high malignant potential, including metastasis, affects patient survival. Bromodomain containing 4 (BRD4) is a chromatin protein that recognizes and associates with acetylated histone lysines, and facilitates transcriptional activation. BRD4 has been implicated in cell proliferation, metastasis, and prognosis in several types of cancer. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
2 Samples

Download data: TXT

Series

Accession:: GSE140858

ID:: 200140858

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000759082.

Kinetics after JQ1 treatment in liver cancer cell

(Submitter supplied) Analysis of global gene expression after BRD4 inhibition by JQ1 in liver cancer cell lines SK-Hep1

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE75908

ID:: 200075908

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000297993.

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukemia

(Submitter supplied) Epigenetic pathways regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. While chromatin alterations are, in principle, reversible and often amendable to drug intervention, the promise of targeting such pathways therapeutically has been hampered by our limited understanding of cancer-specific epigenetic dependencies. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6244 GPL6246
30 Samples

Download data: CEL

Series

Accession:: GSE29799

ID:: 200029799

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001225224.

Therapeutic targeting of BRD4 in head neck squamous cell carcinoma

(Submitter supplied) The bromodomain and extraterminal family members are epigenetic readers and transcriptional coactivators which are critically involved in various biological processes including tumorigenesis. BRD4 has been increasingly appreciated as a key oncogene and promising anticancer target. Here, we sought to characterize the expression of BRD4 and its tumorigenic roles as well as therapeutic targeting in HNSCC. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
4 Samples

Download data: TXT

Series

Accession:: GSE122522

ID:: 200122522

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001582625.

RNA-sequencing reveals signaling pathways associated with tumor invasion and epithelial–mesenchymal transition in HIPK2-attenuated cells

(Submitter supplied) Homeodomain-interacting protein kinase 2 (HIPK2), a well-known tumor suppressor, exhibits contradictory expression patterns in different cancers. This study was performed to reveal the potential mechanism of HIPK2 involvement in oral squamous cell carcinoma (OSCC) metastasis. High throughput RNA-sequencing was used to detect the dysregulated signaling pathways in HIPK2 deficiency OSCC cells. Transwell assay and lymphatic metastatic orthotopic mouse model assay were performed to identify the effect of HIPK2 on tumor invasion. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

Download data: TXT

Series

Accession:: GSE158262

ID:: 200158262

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000623266.

Gene expression profiles of OSCC cells and the metastatic sublines

(Submitter supplied) The orthotopic transplantation of human OEC-M1 cells in immune-compromised mice was established to feasibly study tumorigenesis and lymph node metastasis of OSCC. Through in vivo selection, two sublines, designated as LN1-1 and LN1-2 were successfully isolated from cervical lymph nodes and identified to originate from OEC-M1 cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
3 Samples

Download data: TXT

Series

Accession:: GSE62326

ID:: 200062326

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001450817.

Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role for cellular migration and invasion abilities of prostate cancer

(Submitter supplied) Androgen receptor (AR)-negative castration-resistant prostate cancer (CRPC) is highly aggressive and resistant to current therapies. BET bromodomain protein BRD4 binds to super-enhancers (SEs) that drive high expression of oncogenes in many cancers. A BET inhibitor JQ1 has been found to suppress malignant phenotypes of prostate cancer cells, however, the target genes of JQ1 remains largely unknown. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE145081

ID:: 200145081

Select item 2000803478.

MIA gene family-related signaling in oral squamous cell carcinoma cells

(Submitter supplied) Melanoma inhibitory activity (MIA) gene family is novel tumor-associated molecules. Although MIA gene family has several tumor progressive and/or suppressive functions, the detailed relevant signaling partners are unclear and investigated. In this study, we investigated the detailed MIA gene family-associated signaling using human oral squamous cell carcinoma cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL2895
6 Samples

Download data: TXT

Series

Accession:: GSE80347

ID:: 200080347

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002458899.

Pharmacological targeting of histone H3K27 acetylation/BRD4-dependent induction of ALDH1A3 for early-phase drug tolerance of gastric cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE245889

ID:: 200245889

PubMed Full text in PMC Similar studies

Select item 20024588810.

Pharmacological targeting of histone H3K27 acetylation/BRD4-dependent induction of ALDH1A3 for early-phase drug tolerance of gastric cancer

(Submitter supplied) Drug-tolerant persister (DTP) cells arise in the early phase of chemotherapy and contribute to tumor relapse. In gastric cancer, we previously identified aldehyde dehydrogenase 1 family member A3 (ALDH1A3) as a DTP signature gene that contributes to survival after chemotherapy, while it remains elusive how the ALDH1A3-overexpressing DTP cells are enriched after chemotherapy and contribute to tumor promotion. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE245888

ID:: 200245888

PubMed Full text in PMC Similar studies

Select item 20024588711.

Pharmacological targeting of histone H3K27 acetylation/BRD4-dependent induction of ALDH1A3 for early-phase drug tolerance of gastric cancer

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: CSV

Series

Accession:: GSE245887

ID:: 200245887

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005438012.

Genome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL570 GPL11154
36 Samples

Download data: BW, CEL

Series

Accession:: GSE54380

ID:: 200054380

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005437913.

Genome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]

(Submitter supplied) Here we modeled T-ALL resistance to Notch inhibition, identifying ‘persister’ cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naïve T-ALL populations, and the reversibility of the phenotype is suggestive of an epigenetic mechanism. Relative to GSI-sensitive cells, persisters activate distinct signaling and gene expression programs, and exhibit global chromatin compaction. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
28 Samples

Download data: BW

Series

Accession:: GSE54379

ID:: 200054379

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005437814.

Gene expression profiles of T-cell acute lymphoblastic leukemia cell lines with and without chronic GSI-treatment

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE54378

ID:: 200054378

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023358915.

BET bromodomain inhibition potentiates ocular melanoma therapy by inducing cell cycle arrest

(Submitter supplied) Ocular melanoma is a common primary malignant ocular tumor in adults with limited effective treatments, so novel therapeutic approaches are desperately needed. Epigenetic regulation plays an important role in tumor development. The SWI/SNF chromatin remodeling complex and bromodomain and extraterminal domain (BET) family proteins are epigenetic regulators involved in several cancers. We aimed to screen a candidate small molecule inhibitor targeting the SWI/SNF complex or BET proteins and investigate its effect and mechanism in ocular melanoma. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: TXT

Series

Accession:: GSE233589

ID:: 200233589

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024393616.

P53-P21-RB pathway promotes BRD4 degradation in liver cancer through decreasing USP1 transcription

(Submitter supplied) Liver cancer claims over 800,000 human deaths each year. Liver cancer is notoriously refractory to conventional therapeutics. Further insight into the etiology carries promise for innovative diagnostics and therapeutics. Tumor progression is governed by interplay between tumor promoting genes and suppressor genes. BRD4, an acetyl-lysine binding protein, plays a critical role in development and human diseases. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30209
8 Samples

Download data: TXT

Series

Accession:: GSE243936

ID:: 200243936

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022955817.

Cell state-dependent chromatin targeting in NUT carcinoma

(Submitter supplied) ChIP-seq profiles of BRD4-NUT in HUES64 & HUES64 derived mesoderm (dME). ChIP-seq profiles of BRD4-NUT in Ntera-2 (NT2) cells & Ntera-2 (NT2) differentiated cells after 4 hr and 16 hr retinoic acid treatment..

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
20 Samples

Download data: BED, BW

Series

Accession:: GSE229558

ID:: 200229558

PubMed Full text in PMC Similar studies

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