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Links from GEO DataSets

Items: 19

1.

LPS binding protein and activation signatures are upregulated during asthma exacerbations in children

(Submitter supplied) Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subsequent migration of immune cells into the airways remains incompletely understood. Cellular and molecular profiling of PBMC was employed on paired samples obtained from atopic asthmatic children (n = 19) during acute virus-associated exacerbations and later during convalescence. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
76 Samples
Download data: TXT
2.

Gene expression data from severe asthmatic children: PBMC profiles during acute exacerbation versus convalescence

(Submitter supplied) Severe asthma exacerbations in children requiring hospitalisation are typically associated with viral infection, and occur almost exclusively amongst atopics, but the significance of these comorbidities is unknown. We hypothesised that underlying interactions between immunoinflammatory pathways related to responses to aeroallergen and virus are involved, and that evidence of these interactions is detectable in circulating cells during exacerbations. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3615
Platform:
GPL570
10 Samples
Download data: CEL
Series
Accession:
GSE16032
ID:
200016032
3.
Full record GDS3615

Asthma exacerbation and convalescent phases: peripheral blood mononuclear cells

Analysis of peripheral blood mononuclear cells of children with acute asthma during exacerbation and at subsequent convalescence. Severe asthma exacerbations in children are associated with viral infection and occur among atopics. Results provide insight into the significance of these comorbidities.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE16032
10 Samples
Download data: CEL
DataSet
Accession:
GDS3615
ID:
3615
4.

Acute viral bronchiolitis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
118 Samples
Download data
Series
Accession:
GSE113211
ID:
200113211
5.

Acute viral bronchiolitis (PBMC)

(Submitter supplied) Background: A subset of infants are hyper-susceptible to severe/acute viral bronchiolitis (AVB), for reasons unknown. Purpose: To characterise the cellular/molecular mechanisms underlying infant AVB in circulating cells/local airways tissues. Methods: PBMC and nasal mucosal scrapings (NMS) were obtained from Infants (<18mths) and children (1.5-5yrs) during AVB and post-convalescence. Immune response patterns were profiled by multiplex analysis of plasma cytokines, flow cytometry, and transcriptomics (RNA-Seq). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
62 Samples
Download data: CSV
Series
Accession:
GSE113210
ID:
200113210
6.

Acute viral bronchiolitis (NMS)

(Submitter supplied) Background: A subset of infants are hyper-susceptible to severe/acute viral bronchiolitis (AVB), for reasons unknown. Purpose: To characterise the cellular/molecular mechanisms underlying infant AVB in circulating cells/local airways tissues. Methods: PBMC and nasal mucosal scrapings (NMS) were obtained from Infants (<18mths) and children (1.5-5yrs) during AVB and post-convalescence. Immune response patterns were profiled by multiplex analysis of plasma cytokines, flow cytometry, and transcriptomics (RNA-Seq). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
56 Samples
Download data: CSV
Series
Accession:
GSE113209
ID:
200113209
7.

Virus-induced inflammatory gene networks underlying asthma exacerbations in vivo

(Submitter supplied) Global patterns of gene expression was profiled in nasal lavage samples obtained from asthmatic children during an acute Picornavirus-induced exacerbation and 7-14 days later. Gene coexpression network analysis and prior knowledge was employed to reconstruct the wiring diagram of the underlying gene networks.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4424
Platform:
GPL6244
32 Samples
Download data: CEL
Series
Accession:
GSE30326
ID:
200030326
8.
Full record GDS4424

Acute Picornavirus-induced exacerbation in asthmatic children: nasal lavage cells

Analysis of paired nasal lavage samples obtained from asthmatic children during an acute Picornavirus-induced asthma exacerbation in vivo and 7-14 days later. Severe episodes can be life-threatening. Results provide insight into molecular mechanisms underlying virus-induced asthma exacerbations.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 16 individual, 2 protocol sets
Platform:
GPL6244
Series:
GSE30326
32 Samples
Download data: CEL
9.

Expression in induced sputum during acute exacerbations in asthmatic children with/without chronic airflow obstruction

(Submitter supplied) Asthma exacerbations are associated with subsequent deficits in lung function. Here, we tested the hypothesis that a specific pattern of inflammatory responses during acute exacerbations may be associated with susceptibility to chronic airway obstruction.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
20 Samples
Download data: CEL
Series
Accession:
GSE19903
ID:
200019903
10.

Gene Expression Patterns in Peripheral Blood Mononuclear Cells Associated with Asthma Exacerbation Attack

(Submitter supplied) A large, prospective, non-interventional study was designed to study gene expression changes in peripheral blood mononuclear cells (PBMCs) associated with asthma exacerbations over the course of a year. PBMC samples were collected from subjects at the time of the study visits defined as 1) Quiet: during stable disease at 3 month intervals, 2) Exacerbation: during a 14 day period of deteriorating asthma and 3) Follow-up: within 14 days after cessation of an exacerbation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
685 Samples
Download data: CEL
Series
Accession:
GSE19301
ID:
200019301
11.

A network of transcriptome modules demonstrates mechanistic pathways of both virus induced and non-viral asthma exacerbations in children

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
1034 Samples
Download data
Series
Accession:
GSE115824
ID:
200115824
12.

A network of transcriptome modules demonstrates mechanistic pathways of both virus induced and non-viral asthma exacerbations in children [blood]

(Submitter supplied) We leverage a systems-scale network analysis approach to demonstrate repertoires of cellular transcriptional pathways underlying loss of asthma control, and show how these pathways differ in viral associated and non-viral exacerbations.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
511 Samples
Download data: TXT
13.

A network of transcriptome modules demonstrates mechanistic pathways of both virus induced and non-viral asthma exacerbations in children [nasal]

(Submitter supplied) We leverage a systems-scale network analysis approach to demonstrate repertoires of cellular transcriptional pathways underlying loss of asthma control, and show how these pathways differ in viral associated and non-viral exacerbations.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
523 Samples
Download data: TXT
14.

Human airway epithelial cell response to LPS and house dust mite antigen

(Submitter supplied) Allergic asthmatic, allergy only, asthma only (no allergy), and non-allergic non-asthmatic (control) subjects underwent bronchoscopy with instillation of saline, lipopolysaccharide (LPS), and house dust mite antigen in separate subsegmental bronchi. Airway epithelial cells were collected four hours later (three samples per subject). RNA was extracted from these cells for microarray analysis. Keywords: gene expression arrays (two-dye: sample against common "universal" reference RNA)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1708
250 Samples
Download data: TXT
Series
Accession:
GSE8190
ID:
200008190
15.

DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children.

(Submitter supplied) DNA methylation profiling of airway epithelial cells (AECs) and peripheral blood mononuclear cells (PBMCs) from normal, atopic and asthmatic subjects. The Illumina GoldenGate Methylation Cancer Panel I was used to obtain DNA methylation profiles across approximately 1505 CpGs in AECs and PBMCs. Samples included 7 healthy, 9 atopic, 4 atopic asthmatic and 5 non-atopic asthmatic subjects. Please note that only some of the samples are matched (i.e. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL9183
41 Samples
Download data: TXT
Series
Accession:
GSE37853
ID:
200037853
16.

Single-cell RNA analyses of cattle ruminal epithelial cells

(Submitter supplied) Comprehensive analyses of tissues at single-cell level will benefit our understanding of genetic bases for complex traits. Here we present an initial effort of single-cell transcriptomic analyses of cattle ruminal epithelial cells during the rumen development. We obtained 5064 and 1372 cells from Holstein ruminal epithelial cells before and after weaning, respectively. We reported 6 cell types across their temporal and spatial distributions, which were partially correlated with rumen epithelium layer’s structures and functions. more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23295
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE166473
ID:
200166473
17.

Single-cell RNA analyses of cattle PBMC

(Submitter supplied) Comprehensive analyses of tissues at the single-cell level will benefit our understanding of genetic bases for complex traits. We performed single-cell RNA sequencing (scRNA-seq) analyses of peripheral blood mononuclear cells (PBMCs) from Holstein cattle, investigating their cell types and responses to lipopolysaccharide (LPS) treatment in vitro. The responses to LPS treatment include innate immunity activation of monocytes, macrophages, and dendritic cells, as well as B cell proliferation. more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26012
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE166245
ID:
200166245
18.

Expression data from two rat strains comparing naïve vs 24h picornavirus infection.

(Submitter supplied) Allergic (Th2high immunophenotype) asthmatics have a heightened susceptibility to common respiratory viral infections such as human rhinovirus. Evidence suggests that the innate interferon response is deficient in asthmatic/atopic individuals, whilst other studies show no differences in antiviral response pathways. Unsensitized and OVA-sensitized/challenged Th2high (BN rats) and Th2low immunophenotype (PVG rats) animals were inoculated intranasally with attenuated mengovirus (vMC0). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL23368
12 Samples
Download data: CEL
Series
Accession:
GSE98152
ID:
200098152
19.

Gene expression patterns in house dust mite stimulated CD4 T cells and IgG:IgE ratios

(Submitter supplied) PBMC from house dust mite (HDM) sensitized atopics were cultured in the presence or absence of HDM extract for 24 hours. At the termination of the cultures, CD4 T cells were isolated using immunomagnetic separation. Gene expression was profiled on microarrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20171
90 Samples
Download data: CEL, TXT
Series
Accession:
GSE70760
ID:
200070760
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