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| Status |
Public on May 09, 2009 |
| Title |
Gene expression data from severe asthmatic children: PBMC profiles during acute exacerbation versus convalescence |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Severe asthma exacerbations in children requiring hospitalisation are typically associated with viral infection, and occur almost exclusively amongst atopics, but the significance of these comorbidities is unknown. We hypothesised that underlying interactions between immunoinflammatory pathways related to responses to aeroallergen and virus are involved, and that evidence of these interactions is detectable in circulating cells during exacerbations.
To address this hypothesis we used a genomics-based approach involving profiling of PBMC subpopulations collected during acute exacerbation versus convalescence by microarray and flow cytometry.
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| Overall design |
The study design consisted of 25 atopic subjects, divided into 5 different pools, with each pool containing equal amounts of RNA from 5 subjects, either at acute exacerbation or convalscent stage.
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| Contributor(s) |
Subrata LS, Bizzintino J, Mamessier E, Bosco A, McKenna KL, Wikstrom ME, Goldblatt J, Sly PD, Hales BJ, Thomas WR, Laing IA, LeSouef PN, Holt PG |
| Citation(s) |
19620293 |
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| Submission date |
May 08, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Kathy Laura McKenna |
| E-mail(s) |
kathym@ichr.uwa.edu.au
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| Organization name |
Institute for Child Health Research
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| Street address |
100 Roberts Rd
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| City |
Perth |
| State/province |
Western Australia |
| ZIP/Postal code |
6008 |
| Country |
Australia |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA115389 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE16032_RAW.tar |
78.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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