Similar studies for GEO DataSets (Select 200093186) - GEO DataSets

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Items: 10

Select item 2000931861.

Transcriptomic fingerprints of C. elegans exposed to superparamagnetic iron oxide nanoparticles coated with a monolayer of bovine serum albumin (BSA-SPIONs)

(Submitter supplied) Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are currently being investigated for a range of biomedical applications. Their use have been related with different cytotoxic mechanisms including the generation of oxidative stress and the induction of metal detoxification pathways, among others. Different NP coatings are being explored, among them albumin which has been applied in some drugs delivery systems. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL19230
6 Samples

Download data: CEL

Series

Accession:: GSE93186

ID:: 200093186

Select item 2000931882.

Transcriptomic fingerprints of C. elegans exposed to citrate coated superparamagnetic iron oxide nanoparticles (C-SPIONs) and to superparamagnetic iron oxide nanoparticles coated with a monolayer of bovine serum albumin (BSA-SPIONs)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL19230
12 Samples

Download data: CEL

Series

Accession:: GSE93188

ID:: 200093188

Select item 2000931873.

Transcriptomic fingerprints of C. elegans exposed to citrate coated superparamagnetic iron oxide nanoparticles (C-SPIONs)

(Submitter supplied) Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are currently being investigated for a range of biomedical applications. Their use have been related with different cytotoxic mechanisms including the generation of oxidative stress and the induction of metal detoxification pathways, among others. We have investigated the molecular mechanisms responsive to in-house fabricated citrate coated SPIONs (C-SPIONs) in the nematode C. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL19230
6 Samples

Download data: CEL

Series

Accession:: GSE93187

ID:: 200093187

Select item 2000325214.

Toxicogenomic responses of C. elegans to gold nanoparticles

(Submitter supplied) We used Au nanoparticles (Au-NPs) as a model for studying particle specific effects of manufactured nanomaterials (MNMs) by examining the toxicogenomic responses in a model soil organism, free living nematode Caenorhabditis elegans. Global genome expression for nematodes exposed to 4-nm citrate-coated Au-NPs at the LC10 (5.9 mg L-1) revealed significant differential expression of 797 genes. The levels of expression for five genes (apl-1, dyn-1, act-5, abu-11, and hsp-4) were confirmed independently with qRT-PCR. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS4571
Platform:: GPL200
6 Samples

Download data: CEL

Series

Accession:: GSE32521

ID:: 200032521

Select item 45715.

Toxicogenomic response to gold nanoparticle exposure

Analysis of age-synchronized L3 nematodes exposed to LC10 of gold nanoparticles (Au-NPs). The Au-NPs are used as a model for studying particle-specific effects of manufactured nanomaterials (MNMs). Results provide insight into in vivo particle-specific toxicity of Au-NPs to C. elegans.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL200
Series:: GSE32521
6 Samples

Download data: CEL

DataSet

Accession:: GDS4571

ID:: 4571

Select item 2001459956.

Genome-wide transcriptional profiling of C. elegans in a heavy metal contaminated soil after nZVI treatment

(Submitter supplied) Classical ecotoxicological test and high-throughput molecular tools (microarray) were conducted on C. elegans to assess the effectiveness and ecosafety of a nanoremediation strategy applied to a highly polluted soil environment with heavy metals (HMs). We stablished a profiled gene expression in C. elegans exposed to the polluted soil, treated and untreated with nZVI. The results obtained showed that the percentage of differentially expressed genes decreased with the exposure time to nZVI. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL19230
18 Samples

Download data: CEL

Series

Accession:: GSE145995

ID:: 200145995

Select item 2000576647.

Gene Expression Profiling Reveals Molecular Patterns Underlying the Lifespan-Extending Effect of Tyrosol in Caenorhabditis elegans

(Submitter supplied) We have previously reported that tyrosol (TYR), one of the main phenols in extra virgin olive oil (EVOO), promotes lifespan extension in the nematode Caenorhabditis elegans, also inducing a stronger resistance to thermal and oxidative stress in this animal model. Although the influence of several longevity-related genes in these effects has been reported by our group, we decided to perform a whole genome DNA-microarray approach in order to identify other genes and molecular pathways further involved in TYR effects on C. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
6 Samples

Download data: CEL

Series

Accession:: GSE57664

ID:: 200057664

Select item 2000075358.

Toxicogenomic Analysis of Caenorhabditis elegans Reveals Genes Involved in the Resistance to Cadmium Toxicity

(Submitter supplied) Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes, which can prevent or repair the adverse effects caused by this metal. Using C. elegans, 290 genes were identified that are differentially expressed (≥1.5-fold) following a 4 or 24 hour exposure to cadmium. Several of these genes are known to be involved in metal detoxification, including mtl-1, mtl-2, cdr-1 and ttm-1, confirming the efficacy of the study. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3420
Platform:: GPL2875
36 Samples

Download data: TIFF, TXT

Series

Accession:: GSE7535

ID:: 200007535

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 34209.

Cadmium exposure: time course

Analysis of animals treated with 100 uM cadmium for 4 or 24 hours. Cadmium is a environmental toxicant. Exposure to cadmium is associated with a variety of human diseases. Results provide insight into the molecular mechanisms involved in the defense against cadmium toxicity.