Similar studies for GEO DataSets (Select 200090830) - GEO DataSets

Select item 2000908301.

Integrative proteogenomic characterization of colorectal cancer cell lines and primary tumors

(Submitter supplied) Integrative analysis of global RNASeq and proteomic data comparing human colorectal cancer (CRC) cell lines to primary tumors and normal tissues.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
44 Samples

Download data: TXT

Series

Accession:: GSE90830

ID:: 200090830

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000908142.

Exon array data for patient-matched primary and metastatic colorectal samples

(Submitter supplied) Samples were taken from surgically resected tumor specimens/metastases from patients with colorectal cancer. The expression profiles were determined using the Affymetrix GeneChip Human Exon 1.0 ST Array version 2.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
10 Samples

Download data: CEL

Series

Accession:: GSE90814

ID:: 200090814

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Select item 2000970233.

Expression profiling of colorectal cancer cell lines.

(Submitter supplied) We have performed genome-wide expression analyses as part of a multi-omics study on 34 colorectal cancer cell lines. The data were used for gene expression subtyping of cell lines, gene set analyses and integration with DNA and protein level data.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
34 Samples

Download data: CEL, CHP

Series

Accession:: GSE97023

ID:: 200097023

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Select item 2001005504.

Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
106 Samples

Download data: CEL

Series

Accession:: GSE100550

ID:: 200100550

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Select item 2001005495.

Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models [primary cell lines AMC/Palermo]

(Submitter supplied) Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and clinical perspective. Several distinct molecular entities, such as microsatellite instability (MSI), have been defined that make up biologically distinct subgroups with their own clinical course. Recent data indicated that CRC can be best segregated into four groups called Consensus Molecular Subtypes (CMS1-4), which each have a unique biology and gene expression pattern. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
15 Samples

Download data: CEL

Series

Accession:: GSE100549

ID:: 200100549

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001004806.

Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models [patient tumors and PDX models]

(Submitter supplied) Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and clinical perspective. Several distinct molecular entities, such as microsatellite instability (MSI), have been defined that make up biologically distinct subgroups with their own clinical course. Recent data indicated that CRC can be best segregated into four groups called Consensus Molecular Subtypes (CMS1-4), which each have a unique biology and gene expression pattern. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
55 Samples

Download data: CEL

Series

Accession:: GSE100480

ID:: 200100480

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Select item 2001004797.

Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models [primary cell lines Hubrecht Institute]

(Submitter supplied) Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and clinical perspective. Several distinct molecular entities, such as microsatellite instability (MSI), have been defined that make up biologically distinct subgroups with their own clinical course. Recent data indicated that CRC can be best segregated into four groups called Consensus Molecular Subtypes (CMS1-4), which each have a unique biology and gene expression pattern. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
18 Samples

Download data: CEL

Series

Accession:: GSE100479

ID:: 200100479

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Select item 2001004788.

Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models [cell line panel]

(Submitter supplied) Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and clinical perspective. Several distinct molecular entities, such as microsatellite instability (MSI), have been defined that make up biologically distinct subgroups with their own clinical course. Recent data indicated that CRC can be best segregated into four groups called Consensus Molecular Subtypes (CMS1-4), which each have a unique biology and gene expression pattern. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
18 Samples

Download data: CEL

Series

Accession:: GSE100478

ID:: 200100478

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000725449.

Multi-scale genomic, transcriptomic and proteomic analysis of colorectal cancer cell lines to identify novel biomarkers (BeadChip)

(Submitter supplied) Selecting colorectal cancer (CRC) patients likely to respond to therapy remains a clinical challenge. The objectives of this study were to establish which genes were differentially expressed with respect to treatment sensitivity and relate this to copy number in a panel of 15 CRC cell lines. Copy number variations of the identified genes were assessed in a cohort of colorectal cancers. IC50’s were measured for 5-fluorouracil, oxaliplatin, and BEZ-235, a PI3K/mTOR inhibitor. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
36 Samples

Download data: TXT

Series

Accession:: GSE72544

ID:: 200072544

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Select item 20007229610.

Multi-scale genomic, transcriptomic and proteomic analysis of colorectal cancer cell lines to identify novel biomarkers

(Submitter supplied) The objective of this study was to measure copy number alterations in a panel of 15 CRC cell lines and relate them to treatment sensitivity.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL16707
15 Samples

Download data: GFF, PAIR

Series

Accession:: GSE72296

ID:: 200072296

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Select item 20006777511.

Omics profiling of 21 novel primary and metastatic colorectal cancer cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; SNP genotyping by SNP array

Platforms:: GPL20019 GPL18809 GPL18544
42 Samples

Download data: IDAT

Series

Accession:: GSE67775

ID:: 200067775

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006777412.

SNP-array profiling of 21 novel primary and metastatic colorectal cancer cell lines [Illumina HumanExome-12 v1.2 BeadChip]

(Submitter supplied) Background: In vitro models are an essential tool towards understanding the molecular characteristics of colorectal cancer (CRC) and the testing of therapies for CRC. To this end we established 21 novel CRC cell lines of which six were derived from liver metastases. Extensive genetic, genomic, transcriptomic and methylomic profiling was performed in order to characterize these new cell lines and all data is made publically available. more...

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL20019
16 Samples

Download data: IDAT, TXT

Series

Accession:: GSE67774

ID:: 200067774

PubMed Full text in PMC Similar studies

Select item 20006777313.

SNP-array profiling of 21 novel primary and metastatic colorectal cancer cell lines [Illumina HumanExome-12 v1.0 BeadChip]

(Submitter supplied) Background: In vitro models are an essential tool towards understanding the molecular characteristics of colorectal cancer (CRC) and the testing of therapies for CRC. To this end we established 21 novel CRC cell lines of which six were derived from liver metastases. Extensive genetic, genomic, transcriptomic and methylomic profiling was performed in order to characterize these new cell lines and all data is made publically available. more...

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL18544
5 Samples

Download data: IDAT, TXT

Series

Accession:: GSE67773

ID:: 200067773

PubMed Full text in PMC Similar studies

Select item 20006777214.

BRAF-mutation associated DNA methylation in novel CRC cell lines

(Submitter supplied) Background: In vitro models are an essential tool towards understanding the molecular characteristics of colorectal cancer (CRC) and the testing of therapies for CRC. To this end we established 21 novel CRC cell lines of which six were derived from liver metastases. Extensive genetic, genomic, transcriptomic and methylomic profiling was performed in order to characterize these new cell lines and all data is made publically available. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL18809
21 Samples

Download data: IDAT, TXT

Series

Accession:: GSE67772

ID:: 200067772

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Select item 20003589615.

Gene expression data from 62 colorectal cancers

(Submitter supplied) We stratified colorectal tumor samples using a new unsupervised, iterative method based on non-negative matrix factorization (NMF). The resulting five subtypes exhibited activation of specific signaling pathways, and significant differences in microsatellite status and tumor location. We could also align three CRC cell lines panels to these subtypes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4379
Platform:: GPL570
62 Samples

Download data: CEL

Series

Accession:: GSE35896

ID:: 200035896

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 437916.

Colorectal cancer tumors

Analysis of primary colorectal cancer (CRC) tumors. CRC is a heterogeneous disease. Results provide insight into stratifying CRC tumor samples into subtypes and tailoring treatments for the CRC subtypes.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 6 disease state, 3 genotype/variation, 5 other sets

Platform:: GPL570
Series:: GSE35896
62 Samples

Download data: CEL

DataSet

Accession:: GDS4379

ID:: 4379

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20005583217.

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

(Submitter supplied) Human colorectal cancer (CRC) cell lines are a used widely-used to model system for investigation investigate of tumour biology, experimental therapytherapeutic and biomarkers discovery. However, to what extent these established CRC cell lines represent and maintain the genetic diversity of primary cancers is uncertain. In this study, we analyzed 70 CRC cell lines were analysed for mutations using whole exome sequencing and DNA copy-number using by whole-exome sequencing and SNP microarray profilings, respectively. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL8887
69 Samples

Download data: TXT

Series

Accession:: GSE55832

ID:: 200055832

PubMed Similar studies

Select item 20020680018.

Clariom D assay data from four colorectal cancer patients with tumor, metastasis and normal

(Submitter supplied) Colorectal cancer (CRC) is one of the most prevalent cancers, with more than one million new cases every year worldwide. The prognosis of CRC considerably depends on its disease stage and metastatic status. This study aimed to identify significant expression differences during colorectal progression using a unique set of paired patient samples concerning tumor heterogeneity.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
19 Samples

Download data: CEL

Series

Accession:: GSE206800

ID:: 200206800

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Select item 20012605319.

Integrative Genomics Reveals Mechanisms of Copy Number Alterations Responsible for Transcriptional Deregulation in Colorectal Cancer

(Submitter supplied) To evaluate the mechanisms and consequences of chromosomal aberrations in colorectal cancer (CRC), we used a combination of spectral karyotyping, array comparative genomic hybridization (aCGH), and array-based global gene expression profiling on 31 primary carcinomas and 15 established cell lines. Importantly, aCGH showed that the genomic profiles of primary tumors are recapitulated in the cell lines. more...