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| Status |
Public on Jan 14, 2013 |
| Title |
Gene expression data from 62 colorectal cancers |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We stratified colorectal tumor samples using a new unsupervised, iterative method based on non-negative matrix factorization (NMF). The resulting five subtypes exhibited activation of specific signaling pathways, and significant differences in microsatellite status and tumor location. We could also align three CRC cell lines panels to these subtypes.
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| Overall design |
mRNA from 62 colorectal tumor samples was hybridized to Affymetrix HGU133 Plus 2.0 expression arrays. Log2 gene expression values were calculated using RMA.
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| Contributor(s) |
Schlicker A, Beran G, Chresta CM, McWalter G, Pritchard A, Weston S, Runswick S, Davenport S, Jackson K, Castro DA, Orphanides G, French T, Wessels LF |
| Citation(s) |
23272949 |
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| Submission date |
Feb 16, 2012 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Garry Beran |
| E-mail(s) |
Garry.Beran@AstraZeneca.com
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| Organization name |
AstraZeneca
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| Department |
Oncology
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| Street address |
Mereside, Alderley Park
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| City |
Macclesfield |
| ZIP/Postal code |
SK10 4TG |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (62)
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| Relations |
| BioProject |
PRJNA151957 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE35896_RAW.tar |
283.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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