Similar studies for GEO DataSets (Select 200065037) - GEO DataSets

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Items: 20

Select item 2000650371.

Deconstruction of DNA methylation patterns during myogenesis reveals specific epigenetic events in the establishment of the skeletal muscle lineage

(Submitter supplied) Cellular differentiation involves widespread epigenetic reprogramming, including modulation of DNA methylation patterns. We have investigated DNA genome-wide methylation dynamics in embryonic stem cells, primary myoblasts, terminal differentiated myotubes and mature myofibers. About 1.000 differentially methylated regions (DMRs) have been indentified during muscle-lineage determination and terminal differentiation. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL9250
23 Samples

Download data: TAB

Series

Accession:: GSE65037

ID:: 200065037

PubMed Similar studies SRA Run Selector

Select item 2000220772.

MeDIP-on-chip and Pol-II ChIP-on-chip during C2C12 myogenic and BMP2-induced osteogenic differentiation

(Submitter supplied) Differentiation of pluripotent embryonic stem cells, via more restricted multipotent adult stem cells, towards the multitude of terminally differentiated, specialized cell types that make up the adult body is a multi-step process characterized by a progressive restriction of differentiation potential. Previous studies have demonstrated tissue-specific differences in DNA methylation patterns that might play a role in lineage restriction and tissue-specific gene expression. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array

Platform:: GPL5811
14 Samples

Download data: BAR, BED, CEL

Series

Accession:: GSE22077

ID:: 200022077

PubMed Similar studies

Select item 2000373293.

Genome-wide gene expression during osteogenic and myogenic differentiation from adipose- derived stem cells.

(Submitter supplied) In the current study, we have performed a gene expression analysis of well characterized and defined populations of human adipose-derived stem cells (hASCs) before and after in vitro induction of osteogenic and myogenic differentiation that allows identifying DNA methylation- regulated differentiation genes. We have also address the extent of the epigenetic programming of hASCs- derived differentiated cells by comparing the expression profiling of these cells with their somatic counterparts from primary tissues. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11532
7 Samples

Download data: CEL

Series

Accession:: GSE37329

ID:: 200037329

Select item 2000338964.

Genome-wide CpG methylation during osteogenic and myogenic differentiation from adipose- derived stem cells.

(Submitter supplied) In the current study, we have performed a high-throughput CpG methylation analysis of well characterized and defined populations of human adipose-derived stem cells (hASCs) before and after in vitro induction of osteogenic and myogenic differentiation that allows identifying DNA methylation- regulated differentiation genes. We have also address the extent of the epigenetic programming of hASCs- derived differentiated cells by comparing the methylation profiling of these cells with their somatic counterparts from primary tissues. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
16 Samples

Download data: TXT

Series

Accession:: GSE33896

ID:: 200033896

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000542785.

Functional consequences of DNA-methylation in response to regular exercise

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Methylation profiling by high throughput sequencing

Platforms:: GPL7202 GPL13112
18 Samples

Download data: TXT

Series

Accession:: GSE54278

ID:: 200054278

Select item 2000542776.

Genome-wide changes in DNA methylation in response to physical exercise

(Submitter supplied) Here we describe a genome-wide analysis of DNA-methylation in muscle of trained mice. In comparison to sedentary controls 2762 genes exhibited differentially methylated CpGs in their putative promoter regions. The majority of these genes were related to muscle growth and differentiation and a minor fraction involved in metabolic regulation. These findings suggest that DNA-methylation is involved in the regulation of muscle adaptation to regular exercise training.

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE54277

ID:: 200054277

PubMed Similar studies SRA Run Selector

Select item 2000542767.

Transcriptional changes in skeletal muscle in response to 4 weeks of exercise training

(Submitter supplied) Consequence of physical exercise in skeletal muscle was investigated in C57BL/6 mice after 4 weeks of exercise training and compared to sedentary controls.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE54276

ID:: 200054276

Select item 2001311258.

Gene expression profiling of CHIR99021-induced skeletal myogenesis in human pluripotent stem cells

(Submitter supplied) Human pluripotent stem cell- (hPSC)-derived skeletal muscle progenitors (SMP)—defined as PAX7-expressing cells with myogenic potential—can provide an abundant source of donor material for muscle stem cell therapy owing to the near-infinite replication potential of PSCs. As in vitro myogenesis is decoupled from in vivo timing and the 3D-embryo structure, it remains difficult to definitively characterize what stage or type of muscle is modeled in culture. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20844
24 Samples

Download data: TXT

Series

Accession:: GSE131125

ID:: 200131125

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000979929.

5hmC dynamically correlated with enhancer's activities during hES-to-Pancreatic endoderm cell differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
29 Samples

Download data: BED, BW

Series

Accession:: GSE97992

ID:: 200097992

PubMed Full text in PMC Similar studies

Select item 20009799110.

5hmC dynamically correlated with enhancer's activities during hES-to-Pancreatic endoderm cell differentiation (Bisulfite-Seq)

(Submitter supplied) We generated 5hmC, WGBS and RNAseq of the cells in 5 stages during hES-to-pancreatic endoderm cell differantiation, and investigated the 5hmC correlation with 4 histones (H3K4me1, H3K4me3, H3K27ac and H3K27me3) during this process. Our results showed that 5hmC is dynamically correlate with enhancers' activities.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: BW

Series

Accession:: GSE97991

ID:: 200097991

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009799011.

5hmC dynamically correlated with enhancer's activities during hES-to-Pancreatic endoderm cell differentiation (RNA-Seq)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TXT

Series

Accession:: GSE97990

ID:: 200097990

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009798912.

5hmC dynamically correlated with enhancer's activities during hES-to-Pancreatic endoderm cell differentiation (ATAC-Seq)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
5 Samples

Download data: BED

Series

Accession:: GSE97989

ID:: 200097989

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009798813.

5hmC dynamically correlated with enhancer's activities during hES-to-Pancreatic endoderm cell differentiation (CMS)

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: BED, BW

Series

Accession:: GSE97988

ID:: 200097988

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007815814.

DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

(Submitter supplied) Ectopic expression of the double homeodomain transcription factor DUX4 causes facioscapulohumeral muscular dystrophy (FSHD). Mechanisms of action of DUX4 are currently unknown. Using immortalized human myoblasts with a titratable DUX4 transgene, we identify by mass spectrometry an interaction between the DUX4 C-terminus and the histone acetyltransferases p300/CBP. Chromatin immunoprecipitation shows that DUX4 recruits p300 to its target gene, ZSCAN4, displaces histone H3 from the center of its binding site, and induces H3K27Ac in its vicinity, but C-terminal deleted DUX4 does not. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
15 Samples

Download data: BED, BIGWIG, CSV

Series

Accession:: GSE78158

ID:: 200078158

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20003019215.

Effect of 5-azacytidine on gene expression in C2C12 myoblasts

(Submitter supplied) Mesenchymal progenitor cells can be differentiated in vitro into myotubes that exhibit many characteristic features of primary mammalian skeletal muscle fibers. However, in general, they do not show the functional excitation-contraction coupling or the striated sarcomere arrangement typical of mature myofibers. Epigenetic modifications have been shown to play a key role in regulating the progressional changes in transcription necessary for muscle differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5519
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE30192

ID:: 200030192

Select item 551916.

5-azacytidine effect on mesenchymal progenitor cell line

Analysis of C2C12 mesenchymal progenitor cells treated with 5-azacytidine (5AC). 5AC is a DNA methylation inhibitor and induces genomic demethylation. Results provide insight into the role of DNA demethylation on skeletal myotube maturation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1261
Series:: GSE30192
6 Samples

Download data: CEL

DataSet

Accession:: GDS5519

ID:: 5519

Select item 20006648317.

Expression data from differentiating mouse embryonic stem cells wild type and lacking functional Pax7 gene

(Submitter supplied) Myogenic differentiation relies on Pax7 function. We used embryonic stem cells lacking functional Pax7 to follow its role in derivation of skeletal myoblasts. Microarray analysis allowed us to compare transcriptomes of undifferentiated and differentiating embryonic stem cells of two genotypes, i.e. Pax7+/+ and Pax7-/- at day 7 and 21 of culture.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17400
18 Samples

Download data: CEL

Series

Accession:: GSE66483

ID:: 200066483

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20025339518.

Chromatin profiling reveals many transcriptional regulators of proliferation and differentiation of bovine satellite cells

(Submitter supplied) Satellite cells are myogenic precursor cells in adult skeletal muscle and play a crucial role in skeletal muscle repair, remodeling, and maintenance. Like myoblasts, satellite cells have the ability to proliferate, differentiate, and fuse to form multinucleated myofibers. In this study we aimed to identify the enhancers and the transcription factors binding to these enhancers that control gene expression in proliferating and differentiating bovine satellite cells. more...

Organism:: Bos taurus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL26012
16 Samples

Download data: BW

Series

Accession:: GSE253395

ID:: 200253395

PubMed Full text in PMC Similar studies

Select item 20017103919.

Dissecting mechanisms by which MyoD and small molecules convert fibroblasts to muscle progenitor cells

(Submitter supplied) The generation of myotubes from fibroblasts upon forced MyoD expression is a classic example of factor-induced reprogramming in mammals. We recently discovered that additional modulation of signaling pathways with small molecules facilitates reprogramming to more primitive induced muscle progenitor cells (iMPCs). However, the mechanisms by which a single transcription factor drives differentiated cells into distinct developmental states remain unknown. more...