GEO DataSets

(Submitter supplied) Arsenic is a carcinogenic metalloid element found naturally in the environment; however human activities such as mining and pesticide use have led to increased concentrations in some areas. Silurana tropicalis eggs were exposed to sublethal concentrations of sodium arsenate (0, 0.5 and 1 ppm) for 3 days during embryogenesis. Four pooled of 10 larvae were sampled per treatment and analyzed for gene expression changes using a microarray approach.

Organism:

Xenopus tropicalis

Type:

Expression profiling by array

Platform:

GPL15626

16 Samples

Download data: TXT

(Submitter supplied) To unravel the mechanisms of thalidomide developmental toxicity, we used microarrays to study transcriptomic changes induced by thalidomide during mouse embryonic stem cell (mESC) differentiation. C57BL/6 mESCs were allowed to differentiate spontaneously and global gene expression changes were studied using microarrays at at different time points after exposure to 0.25 mM thalidomide (THD).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

18 Samples

Download data: CEL

(Submitter supplied) http://www.mdyn.com/aptrix/upp01077.nsf/Content/codelink_bioarray_system

Organism:

Mus musculus

1 Series

22 Samples

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(Submitter supplied) African clawed frog Xenopus sp. is used extensively for developmental biology and toxicology research. Amid concerns of environmental pollutants disrupting endocrine systems and causing altered reproductive development in wildlife, eco-toxicology research has led to a focus on linking molecular initiating events to population-level effects. As such, efforts to better understand reproductive development at the molecular level in these model species are warranted. more...

Organism:

Xenopus tropicalis

Type:

Expression profiling by array

Platform:

GPL10263

38 Samples

Download data: CEL

(Submitter supplied) In this study, developing zebrafish were exposed to 500-4500 µg/L BPA for 7 days from 3 hours post-fertilization for a microarray experiment to obtain molecular insights into BPA early-life exposure toxicity.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL10182

18 Samples

Download data: TXT

(Submitter supplied) Trichloroethylene (TCE) is primarily used as an industrial degreasing agent and has been in use since the 1940s. TCE is released into the soil, surface, and groundwater. From an environmental and regulatory standpoint more than half of Superfund hazardous waste sites on the National Priority List are contaminated with TCE. Occupational exposure to TCE occurs primarily via inhalation, while environmental TCE exposure also occurs through ingestion of contaminated drinking water. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL20834

8 Samples

Download data: TXT, XLSX

(Submitter supplied) The in vitro test battery of the European research consortium ESNATS (‘novel stem cell-based test systems’) has been used to screen for potential human developmental toxicants. As part of this effort, the migration of neural crest (MINC) assay has been used to evaluate chemical effects on neural crest function. It identified some drug-like compounds in addition to known environmental toxicants. The hits included the HSP90 inhibitor geldanamycin, the chemotherapeutic arsenic trioxide, the flame-retardant PBDE-99, the pesticide triadimefon and the histone deacetylase inhibitors valproic acid and trichostatin A. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

60 Samples

Download data: CEL, XLSX

(Submitter supplied) Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to twelve weeks. Inorganic arsenic (Asi) is a known human bladder carcinogen. The objective of this study was to examine the concentration dependence of the genomic response to Asi in the urinary bladders of mice. C57BL/6J mice were exposed for 1 or 12 weeks to arsenate in drinking water at concentrations of 0.5, 2, 10, and 50 mg As/L. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

49 Samples

Download data: CEL

(Submitter supplied) The present study used microarray expression profiling to determine the effects of embryonic arsenic exposure. Fertilized killifish (Fundulus heteroclitus) eggs were exposed to 0, 5, 15, or 25ppm arsenic as sodium arsenite. To examine differentially expressed genes, the microarrays were probed using RNA obtained from the control and 25ppm-exposed killifish just after hatching. No differences were noted in survival or hatching success between any of the groups. more...

Organism:

Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL13723

20 Samples

Download data: TXT

(Submitter supplied) We utilized RNASeq to investigate the changes in mRNA expression when retinoic acid signaling is inhibited by treatment with an RAR inhibitor, BMS453.

Organism:

Xenopus laevis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22393

6 Samples

Download data: CSV, TXT

(Submitter supplied) Xenopus laevis embryos were treated with a retinoic acid inhibitior during early orofacial development. The facial tissues were dissected, removing eye and brain tissue from the analysis. RA regulates midface development, we sought to determine global changes in gene expression when RA function is pharmacologically disrupted

Organism:

Xenopus laevis

Type:

Expression profiling by array

Platform:

GPL10756

4 Samples

Download data: CEL

(Submitter supplied) In the present study, we employed the RNA sequencing platform to examine the molecular response of zebrafish liver to arsenic exposure and carry out detailed transcriptomic analyses for further understanding of molecular toxicity. We found that several important biological processes were perturbed by arsenic exposure, including oxidation reduction, translation, iron ion transport, cell redox and homeostasis, as well as related pathways in metabolism and diseases. more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16034

2 Samples

Download data: TXT

(Submitter supplied) Variation in gene expression is known to be important for morphological evolution, however little is known about its general propensity. Here we examine a pair of frogs – Xenopus laevis and Xenopus tropicalis – with highly similar embryology, and ask how their transcriptomes compare. Despite separation for over ~30-90 million years we found a strong conservation in gene expression in the vast majority of the expressed orthologs. more...

Organism:

Xenopus laevis; Xenopus tropicalis

Type:

Expression profiling by array

Platforms:

GPL13127 GPL13126

96 Samples

Download data: TXT

(Submitter supplied) We are investigating the response of human lymphoblastoid cells to low-dose exposure of environmental metals We used microarrays to detail the global programme of gene expression upon response to low-dose metals Keywords: dose

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4915 GDS4916

Platform:

GPL6244

8 Samples

Download data: CEL

Analysis of TK6 lymphoblastoid cells treated with 0.1 uM cadmium chloride for 24 hours. Results provide insight into the molecular impact resulting from exposure to an environmentally relevant dose of cadmium.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6244

Series:

GSE20320

4 Samples

Download data: CEL

Analysis of TK6 lymphoblastoid cells treated with 0.1 uM sodium arsenite for 24 hours. Results provide insight into the molecular impact resulting from exposure to an environmentally relevant dose of arsenic.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6244

Series:

GSE20320

4 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL10332 GPL13912

72 Samples

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(Submitter supplied) Six different carbon nanomaterials (CNM) administered by oropharyngeal aspiration to C57BL/6 mice (on 4 consecutive days with 10ug of CNM per day in PBS, sacrificed on 5th day) and to differentiated THP-1 cells in culture (6 hour and 24 hour, with 100ug of CNM /ml of medium)

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

24 Samples

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(Submitter supplied) Six different carbon nanomaterials (CNM) administered by oropharyngeal aspiration to C57BL/6 mice (on 4 consecutive days with 10ug of CNM per day in PBS, sacrificed on 5th day) and to differentiated THP-1 cells in culture (6 hour and 24 hour, with 100ug of CNM /ml of medium)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

48 Samples

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(Submitter supplied) Our hypothesis is that copper modulates the activity of multiple intracellular signal transduction pathways to affect transcription. We have previously shown that copper activates transcription through both metal- and oxidative stress-responsive signal transduction pathways. Since the global molecular mechanisms underlying copper toxicity have not been well elucidated in humans, we have profiled transcriptome changes in HepG2 cells exposed to 100, 200, 400 and 600 uM copper for 4, 8, 12 and 24 hours using a human oligonucleotide microarray. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3640

Platform:

GPL6087

98 Samples

Download data: TIFF, TXT