Similar studies for GEO DataSets (Select 200032670) - GEO DataSets

Select item 2000326701.

Time-course effect of estradiol and estradiol-BSA on early gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
38 Samples

Download data: CEL

Series

Accession:: GSE32670

ID:: 200032670

Select item 2000326692.

Time-course effect of estradiol and estradiol-BSA on early gene expression in SKBR3 cells

(Submitter supplied) Estrogens have been reported to activate several processes via membrane binding to either classic estrogen receptors (ERs) or GPR30. We have used either estradiol or BSA-conjugated estradiol in order to initiate membrane-initiated actions and ICI 172,780 (ICI) or G15 to explore ER- and GPR30-related transcription. Our results show that the majority of G15-inhibited transcription is depending on ERs, as it is also inhibited by ICI. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE32669

ID:: 200032669

Select item 2000326683.

Time-course effect of estradiol and estradiol-BSA on early gene expression in MDA-MB-231 cells

(Submitter supplied) Estrogens have been reported to activate several processes via membrane binding to either classic estrogen receptors (ERs) or GPR30. We have used either estradiol or BSA-conjugated estradiol in order to initiate membrane-initiated actions and ICI 172,780 (ICI) or G15 to explore ER- and GPR30-related transcription. Our results show that the majority of G15-inhibited transcription is depending on ERs, as it is also inhibited by ICI. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
11 Samples

Download data: CEL

Series

Accession:: GSE32668

ID:: 200032668

Select item 2000326674.

Time-course effect of estradiol and estradiol-BSA on early gene expression in MCF-7 cells

(Submitter supplied) Estrogens have been reported to activate several processes via membrane binding to either classic estrogen receptors (ERs) or GPR30. We have used either estradiol or BSA-conjugated estradiol in order to initiate membrane-initiated actions and ICI 172,780 (ICI) or G15 to explore ER- and GPR30-related transcription. Our results show that the majority of G15-inhibited transcription is depending on ERs, as it is also inhibited by ICI. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE32667

ID:: 200032667

Select item 2000326665.

Time-course effect of estradiol and estradiol-BSA on early gene expression in T47D cells

(Submitter supplied) Estrogens have been reported to activate several processes via membrane binding to either classic estrogen receptors (ERs) or GPR30. We have used either estradiol or BSA-conjugated estradiol in order to initiate membrane-initiated actions and ICI 172,780 (ICI) or G15 to explore ER- and GPR30-related transcription. Our results show that the majority of G15-inhibited transcription is depending on ERs, as it is also inhibited by ICI. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
11 Samples

Download data: CEL

Series

Accession:: GSE32666

ID:: 200032666

Select item 2000647166.

Effect of MEL-18 knockdown on estrogen-sensitive MCF7 breast cancer cells

(Submitter supplied) Gene expression analysis of MEL-18-silenced MCF7 cell lines. MEL-18 is a component of the polycomb repressive complex (PRC)-1, which is a critical epigenetic modulator of stem cell regulation and normal and cancerous development. Accumulating studies have suggested that MEL-18 might act as a tumor suppressor in several human tumors, including breast cancer. Results provide insight into the functional role of MEL-18 in estrogen-dependent breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE64716

ID:: 200064716

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000319427.

Expression data from Estrogen Receptor alpha-positive Progesterone Receptor-positive Mammary Tumors in STAT1-/- Mice.

(Submitter supplied) Aged STAT1-/- female mice spontaneously develop ERa+ PR+ mammary tumors that exhibit strikingly similar hormone-sensitivity and -dependency as human ERa+ luminal breast cancers. We used microarray data to compare the genetic relationships between the STAT1-/- mammary tumors and human breast cancers.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
5 Samples

Download data: CEL

Series

Accession:: GSE31942

ID:: 200031942

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000366838.

Gene Regulation by Estrogen Signaling and DNA Methylation in MCF7 Breast Cancer Cells

(Submitter supplied) Estrogen signaling and epigenetic modifications, in particular DNA methylation, are involved in regulation of gene expression in breast cancers. Here we investigated a potential regulatory cross-talk between these two pathways by identifying their common target genes and exploring potential underlying molecular mechanisms in human MCF7 breast cancer cells. Principal Findings: Gene expression profiling revealed that the expression of approximately 150 genes was influenced by both 17β-estradiol (E2) and a hypomethylating agent 5-aza-2’-deoxycytidine (DAC). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
12 Samples

Download data: CEL, XLS

Series

Accession:: GSE36683

ID:: 200036683

Select item 2000397219.

Time-course effect of estradiol and ERa17p on Early Gene expression in human breast cancer cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE39721

ID:: 200039721

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003972010.

Time-course effect of estradiol and ERa17p on Early Gene expression in T47D cells

(Submitter supplied) ERα17p is a synthetic peptide corresponding to the sequence P295LMIKRSKKNSLALSLT311 of the estrogen receptor alpha (ERα) and initially synthesized to mimic its calmodulin binding site. ERα17p was subsequently found to elicit estrogenic responses in E2-deprived ERα-positive breast cancer cells, increasing proliferation and E2-dependent gene transcription. Surprisingly, in E2-supplemented media, ERα17p induced apoptosis and modified the actin network, influencing thereby cell motility. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL

Series

Accession:: GSE39720

ID:: 200039720

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003971911.

Time-course effect of estradiol and ERa17p on Early Gene expression in SKBR3 cells

(Submitter supplied) ERα17p is a synthetic peptide corresponding to the sequence P295LMIKRSKKNSLALSLT311 of the estrogen receptor alpha (ERα) and initially synthesized to mimic its calmodulin binding site. ERα17p was subsequently found to elicit estrogenic responses in E2-deprived ERα-positive breast cancer cells, increasing proliferation and E2-dependent gene transcription. Surprisingly, in E2-supplemented media, ERα17p induced apoptosis and modified the actin network, influencing thereby cell motility. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL

Series

Accession:: GSE39719

ID:: 200039719

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003971812.

Time-course effect of estradiol and ERa17p on Early Gene expression in MDA-MB-231 cells

(Submitter supplied) ERα17p is a synthetic peptide corresponding to the sequence P295LMIKRSKKNSLALSLT311 of the estrogen receptor alpha (ERα) and initially synthesized to mimic its calmodulin binding site. ERα17p was subsequently found to elicit estrogenic responses in E2-deprived ERα-positive breast cancer cells, increasing proliferation and E2-dependent gene transcription. Surprisingly, in E2-supplemented media, ERα17p induced apoptosis and modified the actin network, influencing thereby cell motility. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL

Series

Accession:: GSE39718

ID:: 200039718

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001571713.

Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors

(Submitter supplied) Whereas estrogens exert their effects by binding to nuclear estrogen receptors and directly altering target gene transcription, they can also initiate extranuclear signaling through activation of kinase cascades. We have investigated the impact of estrogen-mediated extranuclear initiated pathways on global gene expression by using estrpgen-dendrimer conjugates. Keywords: ligand treatment

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
9 Samples

Download data: CEL

Series

Accession:: GSE15717

ID:: 200015717

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000225114.

Anti-prolif. effect of E2 in breast cancer cells that re-exp. ERalpha is mediated by aberr. regulat. of cell cycle genes

(Submitter supplied) Gene expression changes caused by estrogen treatment of breast cancer cells that re-express ERalpha was investigated by infecting ER-negative MDA-MB-231 breast cancer cells for 24 h with recombinant adenovirus encoding full-length human ERalpha (Ad-ERalpha) or control vector (Ad-LacZ), and treating them with 0·01% ethanol (vehicle control) or 10-8 M 17beta-estradiol (E2). After 48 h of treatment, total RNA was isolated and used for transcript profiling on Affymetrix GeneChips. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1326
Platform:: GPL96
12 Samples

Download data

Series

Accession:: GSE2251

ID:: 200002251

Select item 132615.

Breast cancer cells reexpressing estrogen receptor alpha response to 17beta-estradiol

Analysis of the response of estrogen receptor (ER) negative MDA-MB-231 breast cancer cells infected with full-length ER alpha adenoviral constructs to treatment with 17beta-estradiol (E2). Results provide insight into the anti-proliferative effect of E2 on breast cancer cells reexpressing ER.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 protocol sets

Platform:: GPL96
Series:: GSE2251
12 Samples

Download data

DataSet

Accession:: GDS1326

ID:: 1326

Select item 20007179116.

Differences in the Transcriptional Response to Fulvestrant and Estrogen Deprivation in ER-Positive Breast Cancer

(Submitter supplied) Aromatase inhibitors are first-line postmenopausal agents for estrogen receptor alpha (ERa)-positive breast cancer. However, there is considerable response heterogeneity and women frequently relapse. Estrogen deprivation does not completely arrest ERa activity, and transactivation of the unliganded receptor may continue through cross-talk with growth factor pathways. In contrast with aromatase inhibitors, the selective ER downregulator fulvestrant also abrogates ligand-independent ERa activity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
76 Samples

Download data: TXT

Series

Accession:: GSE71791

ID:: 200071791

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003828017.

microRNAs and their target proteins are associated with characteristics of estrogen receptor-positive breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL5639 GPL13746
16 Samples

Download data: GPR

Series

Accession:: GSE38280

ID:: 200038280

Select item 20003827918.

microRNAs and their target proteins associated with characteristics of estrogen receptor-positive breast cancer (mRNA data)

(Submitter supplied) Recent analyses have identified heterogeneity in estrogen receptor (ER)-positive breast cancer. There are so-called luminal A and luminal B subtypes, and the characteristics, such as response to endocrine therapy and chemotherapy and prognosis, are different in these two subtypes of breast cancer. In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissues were compared between highly and incompletely endocrine responsive tumors by miRNA and mRNA microarrays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5639
8 Samples

Download data: GPR

Series

Accession:: GSE38279

ID:: 200038279

Select item 20003827819.

microRNAs and their target proteins are associated with characteristics of estrogen receptor-positive breast cancer (miRNA data)

(Submitter supplied) Recent analyses have identified heterogeneity in estrogen receptor (ER)-positive breast cancer. There are so-called luminal A and luminal B subtypes, and the characteristics, such as response to endocrine therapy and chemotherapy and prognosis, are different in these two subtypes of breast cancer. In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissues were compared between highly and incompletely endocrine responsive tumors by miRNA and mRNA microarrays. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL13746
8 Samples

Download data: GPR

Series

Accession:: GSE38278

ID:: 200038278

Select item 20009254420.

Estrogen sensing by GPER1 activates PI3K/mTOR to promote gender dimorphism in liver growth and cancer

(Submitter supplied) Liver cancer is a common cause of cancer death, with a male-predominant incidence due, in part, to increased estrogen levels in cirrhotic patients. It is unknown, however, how estrogen is sensed to influence this process. Here, we show that estrogen activates the G protein-coupled estrogen receptor 1 (GPER1), expressed in hepatocytes, to enhancing hepatocyte size, cell cycle progression and cell proliferation, thereby increasing liver growth in zebrafish larvae and adults. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20828
12 Samples

Download data: XLSX

Series

Accession:: GSE92544

ID:: 200092544

PubMed Full text in PMC Similar studies SRA Run Selector

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