GEO DataSets

(Submitter supplied) Transcriptional profiling was conducted on RNA from 16 prostatic cancer cell lines to identify genes whose expression level correlate with sensitivity of an anti-tumor agent (dasatinib). Keywords: comparison of sensitive group versus resistant group of cell lines to agent

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3155

Platform:

GPL571

16 Samples

Download data: CEL

Analysis of 16 prostatic cancer cell lines treated with anti-tumor agent dasatinib. The cell lines display sensitivity or resistance to dasatinib. Results used to define a gene expression profile associated with sensitivity to dasatinib.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 16 cell line, 2 other sets

Platform:

GPL571

Series:

GSE9633

16 Samples

Download data: CEL

(Submitter supplied) Transcriptional profiling was conducted on RNA from 23 breast cancer cell lines to identify genes whose expression level correlates with sensitivity of particular drug Keywords: comparison of sensitive group versus resistant group of cell lines to particular drug

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

46 Samples

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(Submitter supplied) Long-term treatment of Kasumi-1 cells at clinically attained doses of dasatinib led to decreased drug-sensitivity by means of IC50 values (relative to treatment-naive cells). Changes were paralled by profound alterations in c-KIT expression and cell signaling signatures. Upon brief discontinuation of dasatinib treatment, these alterations reversed and drug sensitivity was restored. We used gene expression profiling to examine reversal of dasatinib-resistance at the molecular/expression level.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5600

Platform:

GPL6244

9 Samples

Download data: CEL

Analysis of dasatinib-sensitive, KITmut t(8;21) AML cell line Kasumi-1 treated with dasatinib for 12 wks giving rise to R48 cells. After 1 wk of dasatinib cessation, R48 cells give rise to PR48 cells. Results provide insight into molecular effects of long-term dasatinib treatment on t(8;21) AML.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 3 cell line, 3 protocol sets

Platform:

GPL6244

Series:

GSE39073

9 Samples

Download data: CEL

(Submitter supplied) Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasatinib in CML, we analyzed gene expression profiles of mononuclear cells of 7 imatinib-resistant patients, collected before and after 1-year dasatinib treatment. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL4133 GPL9193

54 Samples

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(Submitter supplied) Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasatinib in CML, we analyzed gene expression profiles of mononuclear cells of 7 imatinib-resistant patients, collected before and after 1-year dasatinib treatment. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL9193

26 Samples

Download data: TXT

(Submitter supplied) Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasatinib in CML, we analyzed gene expression profiles of mononuclear cells of 7 imatinib-resistant patients, collected before and after 1-year dasatinib treatment. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

28 Samples

Download data: TXT

(Submitter supplied) RNA expression patterns of liver cell lines were compared to those of liver tumors to determine the suitability of cell lines as a model for drug development studies. The cell lines appear to recapitulate liver tumors.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

20 Samples

Download data: TXT