|Public on Jul 31, 2013
|Gene expression signatures of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib
|Expression profiling by array
Non-coding RNA profiling by array
|Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasatinib in CML, we analyzed gene expression profiles of mononuclear cells of 7 imatinib-resistant patients, collected before and after 1-year dasatinib treatment. Large-scale gene expression was measured with Agilent microarrays covering protein-coding genes and long (>200 nt) noncoding RNAs (lncRNAs). Sets of genes and lncRNAs significantly differentially expressed (>1.5 fold-change; q value ≤10%) were identified. Ingenuity Pathway Analysis pointed to a number of functions, canonical pathways and gene networks that were significantly enriched with differentially expressed genes. In addition to protein-coding genes, lncRNAs have been recently implicated in pathways leading to tumorigenesis. Our data point to new possible regulatory elements involved in dasatinib resistance in CML.
|This SuperSeries is composed of the SubSeries listed below.
Refer to individual Series.
|Oct 27, 2011
|Last update date
|Feb 22, 2018
|Angela A. Fachel
|Weill Cornell Medicine
|1300 York Ave
|Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
|IQUSP Human Intron-Exon 44k v2.0
|Peripheral blood mononuclear cells of 239-Cy3 post-treatment and 128-Cy5 pre-treatment dasatinib non-responder patient
|Peripheral blood mononuclear cells of 239-Cy5 post-treatment and 128-Cy3 pre-treatment dasatinib non-responder patient
|Peripheral blood mononuclear cells of 205-Cy3 post-treatment and 131-Cy5 pre-treatment dasatinib non-responder patient
|This SuperSeries is composed of the following SubSeries:
|Protein coding gene expression profile of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib
|Noncoding RNA expression profile of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib