DataSet Record GDS5600: Expression Profiles Data Analysis Tools Sample Subsets
Title: Acute myeloid leukemia cell line Kasumi-1 response to dasatinib treatment and withdrawal
Cluster AnalysisGDS5600 Cluster Image
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Summary: Analysis of dasatinib-sensitive, KITmut t(8;21) AML cell line Kasumi-1 treated with dasatinib for 12 wks giving rise to R48 cells. After 1 wk of dasatinib cessation, R48 cells give rise to PR48 cells. Results provide insight into molecular effects of long-term dasatinib treatment on t(8;21) AML.
Organism: Homo sapiens
Platform: GPL6244: [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
  • Herrmann MD, Lennerz JK, Bullinger L, Bartholomae S et al. Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression. Exp Hematol 2014 Feb;42(2):90-100. PMID: 24211243
Reference Series: GSE39073 Sample count: 9
Value type: transformed count Series published: 2013/11/27