pyoderma - GEO DataSets

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Select item 2002744891.

IL-12/IL-23 blockade reveals patterns of asynchronous inflammation in pyoderma gangrenosum

(Submitter supplied) Pyoderma Gangrenosum (PG) is a rare and extremely painful neutrophilic dermatosis associated with non-healing cutaneous ulcers affecting 3-10 individuals per million people. The etiology and molecular pathogenetic events of this disease are yet unknown. To investigate how this therapeutic regime shaped the underlying inflammatory response, we performed spatial transcriptomics on lesional biopsies from patients before and after ustekinumab treatment. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
4 Samples

Download data: CSV, JPG, JSON, MTX, PNG, TSV

Series

Accession:: GSE274489

ID:: 200274489

Select item 2002716272.

The Clinical and Molecular Rersponse of Pyoderma Gangrenosum to Interleukin 23 Blockade: results from a proof-of-concept open-label clinical trial

(Submitter supplied) Open Label Clinical Trial

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL31258
28 Samples

Download data: RCC

Series

Accession:: GSE271627

ID:: 200271627

Analyze with GEO2R

Select item 2002410853.

Rapid Attenuation of B-Cell and Interferon Gamma Associated Chemokines in Clinical Responders to Janus Kinase Inhibition with Upadacitinib in Hidradenitis Suppurativa II.

(Submitter supplied) Serum Proteomic Analysis of patients with Pyoderma Gangrenosum Treated with Tildrakizumab 200mg q4weekly for 12 weeks

Organism:: Homo sapiens

Type:: Protein profiling by protein array

Platform:: GPL33500
7 Samples

Download data: XLSX

Series

Accession:: GSE241085

ID:: 200241085

PubMed Similar studies

Select item 2001602604.

Gene expression analysis in canine discoid/chronic lupus erythematosus, mucocutaneous lupus erythematosus and pyoderma

(Submitter supplied) We performed a comparative immunology case study of client-owned dogs to determine if immune and skin gene expression profiles in spontaneous canine cutaneous lupus erythematosus mirror those observed in human cutaneous lupus.

Organism:: Canis lupus familiaris

Type:: Expression profiling by array

Platform:: GPL28844
15 Samples

Download data: RCC

Series

Accession:: GSE160260

ID:: 200160260

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001802765.

Gene expression analysis in complex canine chronic cutaneous lupus erythematosus (CCLE)

(Submitter supplied) We performed a comparative immunology case study of client-owned dogs to determine if immune and skin gene expression profiles in spontaneous canine chronic cutaneous lupus erythematosus (CCLE) with concomitant systemic autoimmunity mirror those observed in human CCLE.

Organism:: Canis lupus familiaris

Type:: Expression profiling by array

Platform:: GPL28844
9 Samples

Download data: RCC

Series

Accession:: GSE180276

ID:: 200180276

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001193086.

Aberrant chromatin landscape upon loss of the H3.3 chaperone Daxx leads to Pu.1-mediated neutrophilia and inflammation [RNA-Seq]

(Submitter supplied) The lymphoid and myeloid lineages are in equilibrium during steady-state hematopoiesis. Tilting hematopoiesis towards innate immunity has been linked to inflammation and may predispose to myeloproliferative disease. Although epigenetic players have been implicated in the control of hematopoiesis and pathogenesis of blood neoplasms, the role of chromatin-based mechanisms in regulating the lymphoid/myeloid balance remains only partially understood. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18480 GPL24247
59 Samples

Download data: TXT

Series

Accession:: GSE119308

ID:: 200119308

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001193067.

Aberrant chromatin landscape upon loss of the H3.3 chaperone Daxx leads to Pu.1-mediated neutrophilia and inflammation [ATAC-Seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18480 GPL24247
24 Samples

Download data: BED, NARROWPEAK, TXT

Series

Accession:: GSE119306

ID:: 200119306

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001679148.

Impaired peripheral mononuclear cell metabolism in patients at risk of developing sepsis

(Submitter supplied) Mitochondrial respiration and gene expression related to mitochondrial function were measured from the peripheral blood of infection and sepsis patients as well as healthy controls

Organism:: Homo sapiens

Type:: Other

Platform:: GPL29783
39 Samples

Download data: TXT

Series

Accession:: GSE167914

ID:: 200167914

Analyze with GEO2R

Select item 2001171689.

Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome

(Submitter supplied) Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is characterized by flares of sterile arthritis with neutrophil infiltrate and the overproduction of Interleukin (IL)-1β. The purpose of this study was to elucidate the potential role of neutrophil subsets and neutrophil extracellular traps (NETs) in the pathogenesis of PAPA. The transcriptome of PAPA normal-dense neutrophils, autologous LDGs, and healthy control normal-dense neutrophils was characterized using RNASeq. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
5 Samples

Download data: TXT

Series

Accession:: GSE117168

ID:: 200117168

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009520310.

Exploring the molecular mechanisms of positive and negative regulation of apoptosis post Orf virus infection in sheep

(Submitter supplied) Contagious ecthyma (Orf) is a contagious disease with worldwide distribution, caused by the epitheliotropic Orf virus (ORFV), a member of the genus Parapoxvirus. In the current study, we collected the oral mucosa tissues samples (T0, T3, T7 and T15) from sheep at 0, 3, 7 and 15 days post ORFV infection, respectively. To explore the changes of comprehensive transcriptome of host cells from oral mucosa tissues post ORFV infection, the RNA-seq transcriptome comparisons were performed on these samples. more...