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Series GSE117168 Query DataSets for GSE117168
Status Public on Oct 23, 2018
Title Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is characterized by flares of sterile arthritis with neutrophil infiltrate and the overproduction of Interleukin (IL)-1β. The purpose of this study was to elucidate the potential role of neutrophil subsets and neutrophil extracellular traps (NETs) in the pathogenesis of PAPA. The transcriptome of PAPA normal-dense neutrophils, autologous LDGs, and healthy control normal-dense neutrophils was characterized using RNASeq. The transcriptome of a PAPA skin biopsy and a healthy control skin sample was elucidated using RNASeq.
Overall design This dataset includes a total of 5 individual samples. This study sought to characterize PAPA normal-dense neutrophils, autologous LDGs, and healthy control normal-dense neutrophils and determine their transcriptomic profiles. We also wanted to characterize the transcriptomic profile of PAPA skin compared to a healthy control skin.
Contributor(s) Mistry P, Carmona-Rivera C, Seto N, Ombrello AK, Hoffmann P, Jones A, Stone DL, Carlucci PM, Dell'Orso S, Gutierrez-Cruz G, Sun HW, Kastner DL, Aksentijevich I, Kaplan MJ
Citation(s) 30131320
Submission date Jul 16, 2018
Last update date Dec 23, 2018
Contact name Hong-wei Sun
Organization name NIAMS
Department Office of Science & Technology
Lab Biodata Mining & Discovery Section
Street address 9000 Rockville Pile
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (5)
GSM3272795 mRNA_HC_NDN_1
GSM3272796 mRNA_PAPA_NDN_1
GSM3272797 mRNA_PAPA_LDG_1
BioProject PRJNA481348
SRA SRP153925

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Supplementary file Size Download File type/resource
GSE117168_PM_RNA-Seq_gene_rpkm_submitted.txt.gz 424.7 Kb (ftp)(http) TXT
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