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| Status |
Public on Aug 28, 2024 |
| Title |
IL-12/IL-23 blockade reveals patterns of asynchronous inflammation in pyoderma gangrenosum |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
Pyoderma Gangrenosum (PG) is a rare and extremely painful neutrophilic dermatosis associated with non-healing cutaneous ulcers affecting 3-10 individuals per million people. The etiology and molecular pathogenetic events of this disease are yet unknown. To investigate how this therapeutic regime shaped the underlying inflammatory response, we performed spatial transcriptomics on lesional biopsies from patients before and after ustekinumab treatment. Our study provides high resolution temporal insights into the inflammatory environment of PG lesional skin following treatment with IL-12/IL-23 blockade in two patients with classic and peristomal PG. This work highlights that while inhibition of representative cytokines of the Th1 and Th17 pathways shows promise as a treatment for PG patients, it does not dampen all active inflammatory pathways.
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| Overall design |
Two PG patients with a samples/skin biopsy before and after ustekinumab administration. All samples were used for the spatial transcriptomic analysis.
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| Contributor(s) |
Moreau JM, Ortega-Loayza AG, Yadav R |
| Citation missing |
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| Submission date |
Aug 10, 2024 |
| Last update date |
Aug 29, 2024 |
| Contact name |
Joshua M Moreau |
| E-mail(s) |
moreauj@ohsu.edu
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| Organization name |
Oregon Health & Science University
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| Department |
Department of Dermatology
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| Lab |
Moreau
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| Street address |
2720 S Moody Ave.
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| City |
Portland |
| State/province |
OR |
| ZIP/Postal code |
97201 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1146733 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE274489_RAW.tar |
140.9 Mb |
(http)(custom) |
TAR (of CSV, JPG, JSON, MTX, PNG, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
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