GEO DataSets

(Submitter supplied) TP53 is mutated in 50% of all cancers, and is often functionally compromised in cancers where it is not mutated. We demonstrate that the pro-tumorigenic/metastatic Six1 homeoprotein decreases p53 levels through a mechanism that does not involve the negative regulator of p53, MDM2. Instead, Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of the ribosomal protein L26 (RPL26), a positive regulator of p53 translation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

5 related Platforms

377 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

50 Samples

Download data: TXT

(Submitter supplied) The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma (IFN-g)) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the program of gene activation in this cellular system. The even spacing and time intervals (every 30 minutes) makes this study amenable to modelling of gene networks in the system.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

25 Samples

Download data: TXT

(Submitter supplied) The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the program of gene activation in this cellular system. The even spacing and time intervals (every 30 minutes) makes this study amenable to modelling of gene networks in the system.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

25 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of HCV core transgenic mice liver comparing nontransgenic mice liver or HCV core transgenic mice liver with various core expression levels.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL2881 GPL891

9 Samples

Download data: TXT

(Submitter supplied) This experiment investigated the response of mouse pulmonary epithelial cells in culture (FE1 cell line) to 3 different brands of cigarette smoke condensate. The three brands represent a full flavour, regular and king-size light cigarettes. These vary in some key chemical consistuents. Brand #1 has the highest tar content. The cells were exposed to two doses: one at approximately 50% cytotoxicity, and the other at approximately 20%. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

66 Samples

Download data: TXT

(Submitter supplied) Breast cancers that are “triple-negative” for the clinical markers ESR1, PGR, and HER2 typically belong to the Basal-like molecular subtype. Defective Rb, p53, and Brca1 pathways are each associated with triple-negative and Basal-like subtypes. Our mouse genetic studies demonstrate that the combined inactivation of Rb and p53 pathways is sufficient to suppress the physiological cell death of mammary involution. more...

Organism:

Mus musculus

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL891

22 Samples

Download data: TXT

(Submitter supplied) The Tuba8 gene was identified as a CAR-regulated gene that was induced during phenobarbital (PB) promotion of liver tumor. TUBA8 was then over-expressed in heaptocarcinoma cells to determine the function of TUBA8.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

6 Samples

Download data: TXT

(Submitter supplied) Background: Toll-like family of receptors recognizes pathogen-associated molecular patterns (PAMPs) from different organisms. TLR4 is the receptor for bacterial lipopolysaccharide (LPS), dsRNA viral mimic poly(I:C) binds to TLR3, and bacterial CpG DNA signals through TLR9. TLR4 signaling is mediated by adaptor molecules Myd88 and TRIF while TLR3 pathway involves only the TRIF adaptor and TLR9 signals solely through Myd88. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

46 Samples

Download data: TXT

(Submitter supplied) We show that macrophages from murine spleen, liver and peritoneum display dramatically different expression profiles. Clusters of genes were found to represent unique biological functions related to adhesion, antigen presentation, phagocytosis, lipid metabolism and signal transduction. Some gene families, such as integrins, are differentially expressed among the macrophages resident in different tissues, suggesting that the tissue of residence influences their biological function.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

18 Samples

Download data: TXT

(Submitter supplied) Genetic profiles of mouse placenta were examined especially at the implantation sites of causing spontaneous abortion at day 14.5 of pregnancy. There is a number of the suffered patients from the recurrent spontaneous abortion by unknown causes. It is an important process to understand genetic profiles in the abortion placentas for the investigation of specific causes to induce rejection of normal embryos from the maternal attack. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

1 Sample

Download data: TXT

(Submitter supplied) The retinoblastoma tumor suppressor, Rb, is implicated in luminal-B and basal-like breast carcinomas, yet its effect on mammary gland development and causal role in breast cancer subtypes remain undefined. Here we show that conditional deletion of Rb in mouse mammary epithelium led to expansion of the stem/progenitor cells and to focal acinar hyperplasia with squamous metaplasia. These uniform lesions progressed into histologically diverse, transplantable mammary adenocarcinomas and adenosquamous carcinomas with features of luminal-B or basal-like carcinomas. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL4092 GPL891 GPL2881

144 Samples

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(Submitter supplied) A number of methods have been proposed to incorporate multiple scans at different intensities to reduce the quantification error and to minimize effects of saturation, but no direct comparison of their efficacy has been made. Here we used 40 technical replicates to compare individual scans at low, medium and high sensitivity with three methods for combining data from multiple scans (either 2 scan or 3 scan cases) using a variety of metrics Keywords: Multiple Scans

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

280 Samples

Download data: TXT

(Submitter supplied) MafB is a member of the large Maf family of transcription factors that share similar basic region/leucine zipper DNA binding motifs and N-terminal activation domains.Although it is well known that MafB is specifically expressed in macrophages, characterization of the null mutant phenotype in these tissues has not been previously reported. To investigate suspected MafB functions macrophages, we generated mafB/green fluorescent protein (GFP) knock-in null mutant mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

1 Sample

Download data: TXT

(Submitter supplied) The present microarray studies the differential transcription levels of various genes upon overexpression of tumor suppressor protein SMAR1. The results will lead us to potential targets which are either up/downregulated by SMAR1.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

1 Sample

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6100 GPL891

34 Samples

Download data: TXT

(Submitter supplied) Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARγ pathway as a therapeutic target in Friedreich's ataxia Friedreich's ataxia (FRDA), the most common inherited ataxia, is characterized by focal neurodegeneration, diabetes mellitus, and life-threatening cardiomyopathy. Frataxin, which is significantly reduced in patients with this recessive disorder, is a mitochondrial iron-binding protein, but how its deficiency leads to neurodegeneration and metabolic derangements is not known. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

12 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to determine the role of ERβ in the response of mouse granulosa cells to PMSG (an FSH analog) by comparing the gene expression profiles of ERβ-het and ERβ-null animals treated with this compound.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

2 Samples

Download data: TIFF, TXT

(Submitter supplied) We examined the impact of chronic lung inflammation on the pulmonary transcriptional response to inhaled urban particles. Transcript levels were measured using high density microarrays in total RNA isolated from whole lungs of wildtype and TNF-α overexpressing mice exposed by inhalation to particulate matter and euthanized immediately or 24 h post-exposure. Keywords: Toxicology, disease state analysis, stress response

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

40 Samples

Download data: TXT

(Submitter supplied) The trans-10, cis-12-isomer of conjugated linoleic acid (CLA) causes a rapid reduction of body and adipose mass in mice by decreasing adipocyte size and number. In addition to changes in adipose tissue, numerous studies have reported alterations in hepatic lipid metabolism. Livers of CLA fed mice gain mass due to lipid accumulation; however, the precise molecular mechanisms are unknown. To elucidate these mechanisms, we examined fatty acid composition and gene expression profiles of livers from a polygenic obese line of mice fed 1% trans-10, cis-12 CLA. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL891

4 Samples

Download data: TXT