|
| Status |
Public on Sep 22, 2010 |
| Title |
Mouse tissue-resident macrophage expression profiles |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We show that macrophages from murine spleen, liver and peritoneum display dramatically different expression profiles. Clusters of genes were found to represent unique biological functions related to adhesion, antigen presentation, phagocytosis, lipid metabolism and signal transduction. Some gene families, such as integrins, are differentially expressed among the macrophages resident in different tissues, suggesting that the tissue of residence influences their biological function.
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| |
|
| Overall design |
18 FACS sorted mouse tissue-resident macrophge samples. 6 cell types, 3 biological replicates per cell type.
|
| |
|
| Contributor(s) |
Ma Y, Clark HF, Gorgani NN |
| Citation(s) |
17998916 |
| |
| Submission date |
Sep 21, 2010 |
| Last update date |
Dec 06, 2012 |
| Contact name |
Yan Ma |
| E-mail(s) |
yanma@gene.com
|
| Phone |
650-225-4284
|
| Organization name |
Gentech Inc
|
| Department |
Bioinformatics
|
| Street address |
1 DNA Way
|
| City |
South San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94080 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL891 |
Agilent-011978 Mouse Microarray G4121A (Feature Number version) |
|
| Samples (18)
|
| GSM596606 |
peritoneal CRIghigh F4/80high Cd11bhigh replicate MN_M |
| GSM596607 |
peritoneal CRIghigh F4/80high Cd11bhigh replicate QR_Q |
| GSM596608 |
peritoneal CRIghigh F4/80high Cd11bhigh replicate UV_U |
| GSM596609 |
peritoneal CRIgnegative F4/80high Cd11bhigh replicate MN_N |
| GSM596610 |
peritoneal CRIgnegative F4/80high Cd11bhigh replicate QR_R |
| GSM596611 |
peritoneal CRIgnegative F4/80high Cd11bhigh replicate UV_V |
| GSM596612 |
splenic CRIgnegative F4/80intermediate Cd11bnegative replicate OP_O |
| GSM596613 |
splenic CRIgnegative F4/80intermediate Cd11bnegative replicate ST_S |
| GSM596614 |
splenic CRIgnegative F4/80intermediate Cd11bnegative replicate WX_W |
| GSM596615 |
splenic CRIgnegative F4/80low Cd11blow replicate OP_P |
| GSM596616 |
splenic CRIgnegative F4/80low Cd11blow replicate ST_T |
| GSM596617 |
splenic CRIgnegative F4/80low Cd11blow replicate WX_X |
| GSM596618 |
Kupffer CRIgwt F4/80high Cd11blow replicate 1 |
| GSM596619 |
Kupffer CRIgwt F4/80high Cd11blow replicate 2 |
| GSM596620 |
Kupffer CRIgwt F4/80high Cd11blow replicate 3 |
| GSM596621 |
Kupffer CRIgko F4/80high Cd11blow replicate 1 |
| GSM596622 |
Kupffer CRIgko F4/80high Cd11blow replicate 2 |
| GSM596623 |
Kupffer CRIgko F4/80high Cd11blow replicate 3 |
|
| Relations |
| BioProject |
PRJNA132983 |
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