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Items: 1 to 20 of 156

1.

Overcoming amphotericin B resistance in Candida auris using the antiemetic drug, rolapitant

(Submitter supplied) The emergence of Candida auris poses a significant health challenge that has led to a new era of multidrug-resistant fungal infections. Invasive infections caused by C. auris are usually associated with remarkable morbidity and mortality. For many years, amphotericin B (AmB) remained the most efficient and the last line of treatment against most hard-to-treat fungal infections. However, strains of C. more...
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
3 Samples
Download data: XLSX
Series
Accession:
GSE263806
ID:
200263806

2.

Rapid in vitro evolution of flucytosine resistance in Candida auris

(Submitter supplied) Comparative transcriptomic profiling of Candida auris derivative clones collected from 5FC-containing medium in comparison to the Wild-Type Strain
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
15 Samples
Download data: TXT
Series
Accession:
GSE272878
ID:
200272878

3.

Candida auris-macrophage cellular interactions and transcriptional response

(Submitter supplied) The pathogenic yeast Candida auris represents a global threat of the utmost clinical relevance. This emerging fungal species is remarkable in its resistance to commonly used antifungal and its persistence in the nosocomial settings. The innate immune system is one the first lines of defense preventing the dissemination of pathogens in the host. C. auris is susceptible to circulating phagocytes, namely neutrophils. more...
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
6 Samples
Download data: SF
Series
Accession:
GSE236004
ID:
200236004

PubMed Full text in PMC Similar studies

4.

Small molecule inhibitors of fungal ∆(9) fatty acid desaturase as antifungal agent against Candida auris

(Submitter supplied) Candida auris has emerged as a significant healthcare-associated pathogen, posing a serious challenge due to its multidrug-resistant nature. Given the pre-existing constraints in the discovery and provision of new antifungals, there is thus an urgent imperative to design effective strategies to tackle this pressing global concern. Here, we screened a chemical library and identified phenyl-carbohydrazide derivatives with potent activity against both C. more...
Organism:
Candida albicans SC5314; Candidozyma auris
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL33190 GPL34459 GPL28368
24 Samples
Download data: TXT
Series
Accession:
GSE267057
ID:
200267057

PubMed Full text in PMC Similar studies

5.

Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris

(Submitter supplied) Candida auris has emerged as a problematic fungal pathogen associated with high morbidity and mortality. Amphotericin B (AmB) is the most effective antifungal used to treat invasive fungal candidiasis, with resistance rarely observed among clinical isolates. However, C. auris possesses extraordinary resistant profiles against all available antifungal drugs, including AmB. In our pursuit of potential solutions, we conducted a screening of a panel of 727 FDA-approved drugs and identified the proton pump inhibitor lansoprazole (LNP) as a potent enhancer of AmB’s activity against C. more...
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
12 Samples
Download data: XLSX
Series
Accession:
GSE244094
ID:
200244094

PubMed Full text in PMC Similar studies

6.

The transcription factor Rpn4 activates its own and efflux pumps’ expression to confer fluconazole resistance in Candida auris

(Submitter supplied) The goal of this RNA-Seq study is to elucidate Rpn4’s function in regulating C. auris fluconazole resistance.
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
9 Samples
Download data: TXT
Series
Accession:
GSE218140
ID:
200218140

PubMed Full text in PMC Similar studies

7.

Understanding environmental and biocide survival of Candida auris through transcriptional profiling

(Submitter supplied) Candida auris is an enigmatic fungal pathogen, recently elevated to the Critical Priority group of fungal pathogens by the World Health Organisation. Of key concern is its ability to cause outbreaks within intensive and chronic care units, which is facilitated through biofilm formation. We investigated the susceptibility of phenotypically-diverse C. auris isolates to sodium hypochlorite (NaOCl) disinfection, and the subsequent role of biofilms in surviving disinfection using a dry-surface biofilm (DSB) model and transcriptomic profiling. more...
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
12 Samples
Download data: TXT
Series
Accession:
GSE239851
ID:
200239851

8.

High-throughput profiling of Candida auris isolates reveals clade-specific metabolic differences

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Candida albicans; Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL28323 GPL28368
30 Samples
Download data
Series
Accession:
GSE223412
ID:
200223412

PubMed Full text in PMC Similar studies

9.

Transcriptional profiling of Candida auris B8441 (CAU30) grown on different carbon and nitrogen sources

(Submitter supplied) Goal of this study was to investigate the metabolic adaptation of C. auris to different carbon sources (malic acid, α-ketoglutarate, proline) and nitrogen sources (dipeptides). As a control medium with glucose as carbon source and ammonium sulfate as nitrogen source was used. Transcriptional profiles were compared after 4 h incubation at 37°C.
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
15 Samples
Download data: CSV
Series
Accession:
GSE223318
ID:
200223318

PubMed Full text in PMC Similar studies

10.

Comparative Transcriptomics Reveal Determinants of Amphotericin B Resistance in Candida auris

(Submitter supplied) Candida auris is an emerging multidrug-resistant human fungal pathogen often refractory to treatment by all classes of antifungal drugs. Amphotericin B (AmB) is a fungicidal drug that, despite its toxic side effects, remains a drug of choice for the treatment of drug-resistant fungal infections, including those caused by C. auris. However, the molecular mechanisms underlying AmB resistance are poorly understood. more...
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
12 Samples
Download data: TXT, XLSX
Series
Accession:
GSE190920
ID:
200190920

PubMed Full text in PMC Similar studies SRA Run Selector

11.

Transcriptomics and phenotyping define signatures associated with echinocandin resistance in Candida auris

(Submitter supplied) Transcriptomic analysis of different Candida auris clinical isolates
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
15 Samples
Download data: TXT
Series
Accession:
GSE198410
ID:
200198410

PubMed Full text in PMC Similar studies

12.

Identification of the lncRNA DINOR as a global stress regulator in the super fungus Candida auris

(Submitter supplied) The goal of this RNA-Seq study is to elucidate DINOR’s function in regulating C. auris morphogenesis.
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
9 Samples
Download data: TXT
Series
Accession:
GSE171261
ID:
200171261

PubMed Similar studies SRA Run Selector

13.

In vitro antifungal activity of myriocin against drug-resistant Candida auris strains

(Submitter supplied) Myriocin exhibited very low MIC values (0.016 to 0.4 mg/L) to all C. auris isolates including several multidrug-resistant strains. The yeast-form, filamentous, or aggregating-form cells were all susceptible to the chemical. The antifungal effect was majorly due to the fungistatic activity, although an extended treatment could lead to the fungicidal activity to C. auris cells. Transcriptomic analysis demonstrates that myriocin suppresses the cellular metabolic activity and induces the expression of stress or antifungal response genes.
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
6 Samples
Download data: TXT
Series
Accession:
GSE161599
ID:
200161599

SRA Run Selector

14.

Aprepitant, an antiemetic agent, displays potent synergistic interactions with azole drugs against emerging multidrug-resistant Candida auris

(Submitter supplied) Combination therapies can be a promising tool to augment the antifungal activity of azole drugs against resistant Candida species. Here, we report the interaction between aprepitant, an antiemetic agent, and azole drugs against different Candida species including the emerging multidrug-resistant C. auris. Particularly, aprepitant enhanced the antifungal activity of itraconazole against C. auris by reducing its minimum inhibitory concentration (MIC) by 2-8 folds. more...
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
4 Samples
Download data: TXT
Series
Accession:
GSE148749
ID:
200148749

PubMed Full text in PMC Similar studies SRA Run Selector

15.

Potent synergistic interactions between lopinavir and azole antifungal drugs against emerging multidrug-resistant Candida auris

(Submitter supplied) The limited number of antifungals and the emergence of multidrug-resistant Candida auris pose a significant challenge to human medicine. Here, we utilized combinatorial drug therapy as an approach to augment the activity of current azole antifungals against C. auris. We evaluated the fluconazole chemosensitization activity of 1547 FDA-approved drugs and clinical molecules against an azole-resistant strain of C. more...
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
4 Samples
Download data: TXT
Series
Accession:
GSE148341
ID:
200148341

PubMed Full text in PMC Similar studies SRA Run Selector

16.

Haploid and Deploid for Candida auris

(Submitter supplied) The expression difference for haploid and deploid of Candida auris
Organism:
Candidozyma auris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28368
9 Samples
Download data: TXT
Series
Accession:
GSE149284
ID:
200149284

SRA Run Selector

17.

Illumina NovaSeq 6000 ([Candida] auris)

Organism:
Candidozyma auris
16 Series
139 Samples
Download data
Platform
Accession:
GPL28368
ID:
100028368

18.

ROL sample 3 [C6]

Organism:
Candidozyma auris
Source name:
AR0390
Platform:
GPL28368
Series:
GSE263806
Download data
Sample
Accession:
GSM8199448
ID:
308199448

SRA Run Selector

19.

ROL sample 2 [C5]

Organism:
Candidozyma auris
Source name:
AR0390
Platform:
GPL28368
Series:
GSE263806
Download data
Sample
Accession:
GSM8199447
ID:
308199447

SRA Run Selector

20.

ROL sample 1 [C4]

Organism:
Candidozyma auris
Source name:
AR0390
Platform:
GPL28368
Series:
GSE263806
Download data
Sample
Accession:
GSM8199446
ID:
308199446

SRA Run Selector

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