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Series GSE161599 Query DataSets for GSE161599
Status Public on Dec 03, 2020
Title In vitro antifungal activity of myriocin against drug-resistant Candida auris strains
Organism [Candida] auris
Experiment type Expression profiling by high throughput sequencing
Summary Myriocin exhibited very low MIC values (0.016 to 0.4 mg/L) to all C. auris isolates including several multidrug-resistant strains. The yeast-form, filamentous, or aggregating-form cells were all susceptible to the chemical. The antifungal effect was majorly due to the fungistatic activity, although an extended treatment could lead to the fungicidal activity to C. auris cells. Transcriptomic analysis demonstrates that myriocin suppresses the cellular metabolic activity and induces the expression of stress or antifungal response genes.
Overall design total RNA profiles of Candida auris cells treated with Myriocin and DMSO
Contributor(s) Huang G, Bing J, Guan Z
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Submission date Nov 17, 2020
Last update date Dec 03, 2020
Contact name Jian Bing
Organization name Fudan University
Department School of Life Sciences
Street address Songhu Road, Yangpu District
City Shanghai
ZIP/Postal code 200438
Country China
Platforms (1)
GPL28368 Illumina NovaSeq 6000 ([Candida] auris)
Samples (6)
GSM4910700 Myriocin-1
GSM4910701 Myriocin-2
GSM4910702 Myriocin-3
BioProject PRJNA678875
SRA SRP292870

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Supplementary file Size Download File type/resource
GSE161599_Cauris-Myriocin.txt.gz 131.7 Kb (ftp)(http) TXT
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Processed data are available on Series record

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