Aframomum rostratum - GEO DataSets

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Select item 2002434211.

Analysis of the mechanism of curcumin against osteoarthritis using transcriptomics

(Submitter supplied) Curcumin is a polyphenolic compound extracted from the turmeric plant (Curcuma longa) and has been extensively studied for its anti-inflammatory and anti-proliferative properties. The safety and effectiveness of curcumin have been thoroughly proven. However, the mechanisms underlying the treatment of osteoarthritis remain unclear. This study aimed to reveal the potential mechanism of curcumin in the treatment of osteoarthritis through metabolomics and transcriptomics. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: TXT

Series

Accession:: GSE243421

ID:: 200243421

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001798442.

Effect of Curcuphenols and cannaniboids on H3K27Ac marks in cell lines

(Submitter supplied) Turmeric, is both a culinary spice but also used it traditional medicines and dietary supplements for a growing list of disorder including arthritis, digestive disorders respiratory infections, allergies, liver disease, depression. The activities of turmeric are commonly attributed to curcuminoids. To understand this, In this study we compare the alters epigenetic H3K27Ac marks caused by curcupheols and cannabinoids in tissue culture cell lines.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: BED

Series

Accession:: GSE179844

ID:: 200179844

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001564723.

Transcriptomic profiling of human senescent cells in the setting of curcumin intervention

(Submitter supplied) Aging and age-relataed pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using small molecules would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of curcumin, a polyphenol constituent (up to ∼5%) of the traditional medicine known as turmeric, in targeting senescent cells via induction of programmed cell death. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
9 Samples

Download data: XLS

Series

Accession:: GSE156472

ID:: 200156472

Analyze with GEO2R SRA Run Selector

Select item 2002017794.

Curcuma longa and Boswellia serrata extracts modulate different and complementary pathways on human chondrocytes in vitro: deciphering of a transcriptomic study

(Submitter supplied) Objectives: Curcuma longa (CL) and Boswellia serrata (BS) extracts are used to relieve osteoarthritis symptoms. The aim of this in vitro study was to investigate their mechanisms of action at therapeutic plasmatic concentrations on primary human osteoarthritic (OA) chondrocytes.Methods: BS (10-50 µg/mL) and CL (0.4-2 µg/mL corresponding to 1-5 µM of curcumin) were evaluated separately or in combination on primary chondrocytes isolated from 17 OA patients and cultured in alginate beads. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
140 Samples

Download data: TXT

Series

Accession:: GSE201779

ID:: 200201779

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002095285.

Expression data from tibialis anterior muscle of mice with or without treatment of dexamethasone and/or tumeric extract

(Submitter supplied) Sarcopenia is the decline in skeletal muscle mass, strength, and functions, which decreases the quality of life in elderly people. This study investigated the suppressive effect of turmeric (Curcuma longa) extract (TE) on muscle atrophy in dexamethasone (DEX)-treated mice and C2C12 myotubes. DEX treatment significantly decreased the muscle weight and significantly increased Fbxo32 and Murf1 expression in mice, and these changes were suppressed by the supplementation of an AIN-93 based diet with 2% TE. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL

Series

Accession:: GSE209528

ID:: 200209528

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001690056.

Transcriptomics analysis of mouse tumor sample

(Submitter supplied) A total of 30 differential genes were callbacked in colon tumor samples after AC(Astragalus zedoary extract) treatment.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: TXT

Series

Accession:: GSE169005

ID:: 200169005

SRA Run Selector

Select item 2001426807.

Galangin suppress H19 expression inducedpromotes cell apoptosis in hepatocellular carcinoma cells through suppression of H19 expression

(Submitter supplied) Galangin, a natural flavonoid, derived from honey and Alpinia officinarum Hance (Zingiberaceae) has excellent was anti-tumor and anti-inflammatory properties. w It has been extensively studied as a novel therapeutic agent forhich was widely used in the treatment of various cancers. However, the effect of galangin in HCC remains elusive. Using RNA sequencing, the differential expression of LncRNA in MHCC97H cells treated with galangin was investigated in the present study. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL20795
6 Samples

Download data: XLSX

Series

Accession:: GSE142680

ID:: 200142680

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000598798.

Adaptive mechanism of Campylobacter jejuni to treatment with a novel CmeABC efflux pump inhibitor (-)-α-Pinene

(Submitter supplied) Objectives: The aim of the study was to characterize (-)-α-Pinene, which is one of the chemical constituents of Alpinia katsumadai seed essential oil responsible for its resistance modulatory activity in Campylobacter jejuni. Methods: Broth microdilution method was used to evaluate the antimicrobial and resistance modulatory potential of (-)-α-Pinene and ethidium bromide accumulation assay to determine its efflux-inhibitory activity in subinhibitory concentration. more...

Organism:: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

Type:: Expression profiling by array

Platform:: GPL19011
4 Samples

Download data: GPR

Series

Accession:: GSE59879

ID:: 200059879

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000472119.

Curcumin intake affects miRNA signature in murine melanoma with mmu-miR-205-5p most significantly altered.

(Submitter supplied) Melanoma is the most aggressive form of skin cancer with estimated 48,000 deaths worldwide. The polyphenol curcumin derived from the plant Curcuma longa is well known for its anti-inflammatory and anti-cancerogenic properties. Accordingly, dietary intake of this compound may be suitable for melanoma prevention. However, how this compound affects basic cellular mechanisms in developing melanoma still remains elusive. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL16275
13 Samples

Download data: TXT

Series

Accession:: GSE47211

ID:: 200047211

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003781310.

Effect of dietary supplementation with Curcuma longa (turmeric) during Eimeria maxima and Eimeria tenella infection of chickens

(Submitter supplied) This study utilized comparative global gene expression microarray analysis to evaluate the effects of curcumin on intestinal immunity of chicken.

Organism:: Gallus gallus

Type:: Expression profiling by array

Platform:: GPL13820
2 Samples

Download data: TXT

Series

Accession:: GSE37813

ID:: 200037813

Select item 20002118211.

Curcumin Extends Lifespan, Improves Healthspan, and Modulates the Expression of Age-Associated Aging Genes in Drosophila melanogaster

(Submitter supplied) Curcumin, a yellow pigment extracted from the rhizome of the plant Curcuma longa (turmeric) has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities such as anti-oxidative, anti-inflammatory, anti-cancer, chemopreventive, and anti-neurodegenerative properties. We evaluated the impact of curcumin on lifespan, fecundity, feeding rate, oxidative stress, locomotion and gene expression in two different wild type Drosophila melanogaster strains, Canton-S and Ives, under two different experimental conditions. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
4 Samples

Download data: CEL

Series

Accession:: GSE21182

ID:: 200021182

Select item 20001698212.

Ginger and Turmeric microarray in different tissues at different developmental stages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Zingiber officinale; Curcuma longa

Type:: Expression profiling by array

Platform:: GPL8746
48 Samples

Download data: TXT

Series

Accession:: GSE16982

ID:: 200016982

Analyze with GEO2R

Select item 20001673313.

Analysis of Gene Expression in Tissues of Two Turmeric Varieties at Different Developmental Stages

(Submitter supplied) Two varieties of turmeric, FMO (Fat Mild Orange) and TYA (Thin Yellow Aromatic) were compared. Rhizomes were harvested 3, 5, and 7 months after planting, roots were harvested at 7 months, and leaves were harvested at 7 months. Plants were grown under controlled conditions in the greenhouse.