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Burkitt Leukemia

MedGen UID:
1658558
•Concept ID:
C4721444
•
Neoplastic Process
Synonyms: Burkitt Cell Leukemia; Burkitt's Leukemia; Burkitts Leukemia; L3 Lymphocytic Leukemia; L3 Lymphocytic Leukemias; Leukemia, Burkitt; Leukemia, Burkitt Cell; Leukemia, Burkitt's; Leukemia, L3 Lymphocytic; Leukemia, Lymphoblastic, Burkitt-Type; Leukemia, Lymphocytic, L3; Lymphocytic Leukemia, L3
SNOMED CT: Acute lymphoblastic leukemia, mature B-cell type (22197008); Burkitt cell leukemia (22197008); Burkitt's cell leukemia (22197008); Acute lymphoblastic leukemia, Burkitt's type (22197008); Burkitt's leukemia (277571004)

Definition

The leukemic counterpart of Burkitt''s lymphoma. The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood. This is an aggressive leukemia. [from NCI]

Professional guidelines

PubMed

Liposomal cytarabine in prophylaxis or curative treatment of central nervous system involvement in Burkitt leukemia/lymphoma.
Segot A, Raffoux E, Lengline E, Thieblemont C, Dombret H, Boissel N, Cluzeau T
Ann Hematol 2015 Nov;94(11):1859-63. Epub 2015 Aug 18 doi: 10.1007/s00277-015-2475-z. PMID: 26280395

Recent clinical studies

Etiology

Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.
Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Bridging the gap in outpatient care: Can a daily patient-reported outcome measure help?
Meryk A, Kropshofer G, Hetzer B, Riedl D, Lehmann J, Rumpold G, Haid A, Holzner B, Crazzolara R
Cancer Rep (Hoboken) 2022 Jan;5(1):e1421. Epub 2021 Jul 10 doi: 10.1002/cnr2.1421. PMID: 34245127Free PMC Article
Long-term outcome of hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse.
Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
Progressive or relapsed Burkitt lymphoma or leukemia in children and adolescents after BFM-type first-line therapy.
Woessmann W, Zimmermann M, Meinhardt A, Müller S, Hauch H, Knörr F, Oschlies I, Klapper W, Niggli F, Kabickova E, Attarbaschi A, Reiter A, Burkhardt B
Blood 2020 Apr 2;135(14):1124-1132. doi: 10.1182/blood.2019003591. PMID: 31961927
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Diagnosis

Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
TCF3-HLF-Positive Acute Lymphoblastic Leukemia Resembling Burkitt Leukemia: Cell Morphologic and Immunophenotypic Findings.
Li MJ, Yu CH, Chou SW, Su YH, Liao KW, Chang HH, Yang YL
JCO Precis Oncol 2022 Aug;6:e2200236. doi: 10.1200/PO.22.00236. PMID: 36001860Free PMC Article
Burkitt leukemia.
Huang Q
Arch Pathol Lab Med 2004 Dec;128(12):1459-60. doi: 10.5858/2004-128-1459-BL. PMID: 15578900
Adult Burkitt leukemia and lymphoma.
Blum KA, Lozanski G, Byrd JC
Blood 2004 Nov 15;104(10):3009-20. Epub 2004 Jul 20 doi: 10.1182/blood-2004-02-0405. PMID: 15265787
Oncogenes and leukemia.
Butturini A, Gale RP
Leukemia 1990 Feb;4(2):138-60. PMID: 2406517

Therapy

Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
Monoclonal antibodies in frontline acute lymphoblastic leukemia.
Chew S, Jammal N, Kantarjian H, Jabbour E
Best Pract Res Clin Haematol 2020 Dec;33(4):101226. Epub 2020 Nov 18 doi: 10.1016/j.beha.2020.101226. PMID: 33279178
Burkitt Leukemia Presenting as Acute Appendicitis: A Case Report and Literature Review.
Mimery AH, Jabbour J, Sykes B, MacDermid E, Al-Askari M, De Clercq S
Am J Case Rep 2020 Feb 13;21:e921568. doi: 10.12659/AJCR.921568. PMID: 32094318Free PMC Article
Monoclonal antibodies in acute lymphoblastic leukemia.
Jabbour E, O'Brien S, Ravandi F, Kantarjian H
Blood 2015 Jun 25;125(26):4010-6. Epub 2015 May 21 doi: 10.1182/blood-2014-08-596403. PMID: 25999456Free PMC Article
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Prognosis

Long-term outcome of hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse.
Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
Burkitt leukemia limited to the bone marrow has a better prognosis than Burkitt lymphoma with bone marrow involvement in adults.
Song JY, Venkataraman G, Fedoriw Y, Herrera AF, Siddiqi T, Alikhan MB, Kim YS, Murata-Collins J, Weisenburger DD, Liu X, Duffield AS
Leuk Lymphoma 2016;57(4):866-71. Epub 2015 Oct 8 doi: 10.3109/10428194.2015.1085529. PMID: 26450341
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584
Williams-Beuren Syndrome and Burkitt Leukemia.
Zhukova N, Naqvi A
J Pediatr Hematol Oncol 2013 Jan;35(1):e30-2. doi: 10.1097/MPH.0b013e318270672f. PMID: 23018576
Adult Burkitt leukemia and lymphoma.
Blum KA, Lozanski G, Byrd JC
Blood 2004 Nov 15;104(10):3009-20. Epub 2004 Jul 20 doi: 10.1182/blood-2004-02-0405. PMID: 15265787

Clinical prediction guides

Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
Long-term outcome of hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse.
Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
Burkitt Leukemia With Precursor B-Cell Immunophenotype and Dual Translocation of t(14;18) and t(8;14) in a Child: Case Report and Review of the Literature.
Odaman Al I, Bayram C, Koç B, Ersoy G, Pasli Uysalol E, Aki H, Özdemir GN
J Pediatr Hematol Oncol 2020 Jan;42(1):e61-e63. doi: 10.1097/MPH.0000000000001354. PMID: 30499905
High cure rates in Burkitt lymphoma and leukemia: a Northern Italy Leukemia Group study of the German short intensive rituximab-chemotherapy program.
Intermesoli T, Rambaldi A, Rossi G, Delaini F, Romani C, Pogliani EM, Pagani C, Angelucci E, Terruzzi E, Levis A, Cassibba V, Mattei D, Gianfaldoni G, Scattolin AM, Di Bona E, Oldani E, Parolini M, Gökbuget N, Bassan R
Haematologica 2013 Nov;98(11):1718-25. Epub 2013 Jun 10 doi: 10.3324/haematol.2013.086827. PMID: 23753030Free PMC Article
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Recent systematic reviews

Pediatric precursor B-cell acute lymphoblastic leukemia with MYC 8q24 translocation - how to treat?
Zhang C, Amos Burke GA
Leuk Lymphoma 2018 Aug;59(8):1807-1813. Epub 2017 Oct 12 doi: 10.1080/10428194.2017.1387914. PMID: 29022749

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