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Cutaneous Squamous Cell Carcinoma of the Head and Neck

MedGen UID:
1614715
•Concept ID:
C4524517
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the skin of the head and neck. [from NCI]

Professional guidelines

PubMed

Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).
Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT
Int J Radiat Oncol Biol Phys 2020 Jul 15;107(4):641-651. Epub 2020 Apr 11 doi: 10.1016/j.ijrobp.2020.03.024. PMID: 32289475
Management of locoregional recurrence in cutaneous squamous cell carcinoma of the head and neck.
Strassen U, Hofauer B, Jacobi C, Knopf A
Eur Arch Otorhinolaryngol 2017 Jan;274(1):501-506. Epub 2016 Aug 6 doi: 10.1007/s00405-016-4243-7. PMID: 27498202
Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck.
D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

Recent clinical studies

Etiology

Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.
Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347Free PMC Article
High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region.
Staackmann C, Schild SE, Rades D
In Vivo 2021 Jul-Aug;35(4):2283-2288. doi: 10.21873/invivo.12501. PMID: 34182507Free PMC Article
Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).
Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT
Int J Radiat Oncol Biol Phys 2020 Jul 15;107(4):641-651. Epub 2020 Apr 11 doi: 10.1016/j.ijrobp.2020.03.024. PMID: 32289475
Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.
Tam S, Gross ND
Curr Oncol Rep 2019 Jul 29;21(9):82. doi: 10.1007/s11912-019-0831-1. PMID: 31359288

Diagnosis

Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.
Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347Free PMC Article
High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Survival after parotid gland metastases of cutaneous squamous cell carcinoma of the head and neck.
Meyer MF, Wolber P, Arolt C, Wessel M, Quaas A, Lang S, Klussmann JP, Semrau R, Beutner D
Oral Maxillofac Surg 2021 Sep;25(3):383-388. Epub 2021 Jan 5 doi: 10.1007/s10006-020-00934-8. PMID: 33400041Free PMC Article
Survival Outcomes for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Sullivan CB, Andresen NS, Kendell N, Al-Qurayshi Z, Pagedar NA
Ann Otol Rhinol Laryngol 2019 Oct;128(10):949-955. Epub 2019 May 15 doi: 10.1177/0003489419848786. PMID: 31091995

Therapy

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies?
Zilberg C, Lee MW, Kraitsek S, Ashford B, Ranson M, Shannon K, Iyer NG, Ch'ng S, Low TH, Palme C, Clark J, Gupta R, Yu B
J Clin Pathol 2020 Jan;73(1):17-22. Epub 2019 Jul 12 doi: 10.1136/jclinpath-2019-206038. PMID: 31300530
Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.
Tam S, Gross ND
Curr Oncol Rep 2019 Jul 29;21(9):82. doi: 10.1007/s11912-019-0831-1. PMID: 31359288
Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial.
Porceddu SV, Bressel M, Poulsen MG, Stoneley A, Veness MJ, Kenny LM, Wratten C, Corry J, Cooper S, Fogarty GB, Collins M, Collins MK, Macann AMJ, Milross CG, Penniment MG, Liu HY, King MT, Panizza BJ, Rischin D
J Clin Oncol 2018 May 1;36(13):1275-1283. Epub 2018 Mar 14 doi: 10.1200/JCO.2017.77.0941. PMID: 29537906

Prognosis

Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.
Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347Free PMC Article
High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region.
Staackmann C, Schild SE, Rades D
In Vivo 2021 Jul-Aug;35(4):2283-2288. doi: 10.21873/invivo.12501. PMID: 34182507Free PMC Article
Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.
Tam S, Gross ND
Curr Oncol Rep 2019 Jul 29;21(9):82. doi: 10.1007/s11912-019-0831-1. PMID: 31359288
Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck.
D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

Clinical prediction guides

Lymph node metastasis in cutaneous squamous cell carcinoma of the head and neck.
Fang Q, Yuan J, Zhang X, Dai L, Luo R
BMC Cancer 2024 May 29;24(1):656. doi: 10.1186/s12885-024-12384-6. PMID: 38811899Free PMC Article
High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region.
Staackmann C, Schild SE, Rades D
In Vivo 2021 Jul-Aug;35(4):2283-2288. doi: 10.21873/invivo.12501. PMID: 34182507Free PMC Article
The role of parotidectomy for advanced cutaneous squamous cell carcinoma of the head and neck.
Kampel L, Dorman A, Horovitz G, Warshavsky A, Gutfeld O, Muhanna N
Eur Arch Otorhinolaryngol 2021 Oct;278(10):3955-3963. Epub 2021 Jan 6 doi: 10.1007/s00405-020-06574-8. PMID: 33404750
Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck.
D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

Recent systematic reviews

Sentinel lymph node biopsy in high-risk cutaneous squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.
Costantino A, Canali L, Festa BM, Spriano G, Mercante G, De Virgilio A
Head Neck 2022 Oct;44(10):2288-2300. Epub 2022 Jun 17 doi: 10.1002/hed.27121. PMID: 35713173
Outcomes of Cutaneous Squamous Cell Carcinoma in the Head and Neck Region With Regional Lymph Node Metastasis: A Systematic Review and Meta-analysis.
Sahovaler A, Krishnan RJ, Yeh DH, Zhou Q, Palma D, Fung K, Yoo J, Nichols A, MacNeil SD
JAMA Otolaryngol Head Neck Surg 2019 Apr 1;145(4):352-360. doi: 10.1001/jamaoto.2018.4515. PMID: 30844021Free PMC Article
Immunosuppression Impact on Head and Neck Cutaneous Squamous Cell Carcinoma: A Systematic Review with Meta-analysis.
Elghouche AN, Pflum ZE, Schmalbach CE
Otolaryngol Head Neck Surg 2019 Mar;160(3):439-446. Epub 2018 Oct 23 doi: 10.1177/0194599818808511. PMID: 30348055

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