U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

MedGen UID:
1770888
Concept ID:
C5419186
Neoplastic Process

Definition

Cutaneous squamous cell carcinoma of the head and neck that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

Professional guidelines

PubMed

Leus AJG, Horváth B, Terra JB, Diercks GFH, Plaat BEC, Oosting SF, Rácz E
Br J Dermatol 2022 Feb;186(2):371-372. Epub 2021 Nov 2 doi: 10.1111/bjd.20774. PMID: 34597438Free PMC Article
Trosman SJ, Zhu A, Nicolli EA, Leibowitz JM, Sargi ZB
Laryngoscope 2021 Jan;131(1):E136-E143. Epub 2020 Feb 17 doi: 10.1002/lary.28564. PMID: 32065413

Recent clinical studies

Etiology

Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Diagnosis

Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Therapy

Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Prognosis

Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Khandelwal AR, Echanique KA, St John M, Nathan CA
Otolaryngol Clin North Am 2021 Apr;54(2):259-269. Epub 2021 Feb 11 doi: 10.1016/j.otc.2020.11.002. PMID: 33583599
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Clinical prediction guides

Hanna GJ, Dharanesswaran H, Giobbie-Hurder A, Harran JJ, Liao Z, Pai L, Tchekmedyian V, Ruiz ES, Waldman AH, Schmults CD, Riella LV, Lizotte P, Paweletz CP, Chandraker AK, Murakami N, Silk AW
J Clin Oncol 2024 Mar 20;42(9):1021-1030. Epub 2024 Jan 22 doi: 10.1200/JCO.23.01498. PMID: 38252908Free PMC Article
Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Recent systematic reviews

Zhang H, Zhong A, Chen J
Skin Res Technol 2023 Jan;29(1):e13229. Epub 2022 Nov 3 doi: 10.1111/srt.13229. PMID: 36329570Free PMC Article
Mehta NK, Li AR, Nguyen SA, Kaczmar JM, Neskey DM, Day TA
Target Oncol 2021 Nov;16(6):743-752. Epub 2021 Oct 22 doi: 10.1007/s11523-021-00844-z. PMID: 34677815
Sahovaler A, Krishnan RJ, Yeh DH, Zhou Q, Palma D, Fung K, Yoo J, Nichols A, MacNeil SD
JAMA Otolaryngol Head Neck Surg 2019 Apr 1;145(4):352-360. doi: 10.1001/jamaoto.2018.4515. PMID: 30844021Free PMC Article
Lenzi R, Muscatello L, Saibene AM, Felisati G, Pipolo C
Eur Arch Otorhinolaryngol 2017 Jun;274(6):2389-2394. Epub 2017 Feb 24 doi: 10.1007/s00405-017-4490-2. PMID: 28236011
Dedivitis RA, Aires FT, Cernea CR, Brandão LG
Head Neck 2015 Nov;37(11):1691-7. Epub 2015 Jun 26 doi: 10.1002/hed.23804. PMID: 24958209

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...