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Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck

MedGen UID:
1691326
•Concept ID:
C4733552
•
Neoplastic Process

Definition

The reemergence of cutaneous squamous cell carcinoma of the head and neck after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck

Professional guidelines

PubMed

Surgical management of recurrent cutaneous squamous cell carcinoma of the head and neck after definitive surgery and radiotherapy.
Toppi J, Tham YS, Webb A, Henderson MA, Rischin D, Magarey MJR
ANZ J Surg 2020 Jul;90(7-8):1391-1395. Epub 2020 Jul 5 doi: 10.1111/ans.16095. PMID: 32627359

Recent clinical studies

Etiology

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.
Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347Free PMC Article
Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial.
Sacco AG, Chen R, Worden FP, Wong DJL, Adkins D, Swiecicki P, Chai-Ho W, Oppelt P, Ghosh D, Bykowski J, Molinolo A, Pittman E, Estrada MV, Gold K, Daniels G, Lippman SM, Natsuhara A, Messer K, Cohen EEW
Lancet Oncol 2021 Jun;22(6):883-892. Epub 2021 May 11 doi: 10.1016/S1470-2045(21)00136-4. PMID: 33989559
Cutaneous sebaceous carcinoma.
Wu A, Rajak SN, Huilgol SC, James C, Selva D
Australas J Dermatol 2020 Aug;61(3):e283-e292. Epub 2020 Jan 19 doi: 10.1111/ajd.13234. PMID: 31956994
Guidelines of care for the management of cutaneous squamous cell carcinoma.
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Diagnosis

Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.
Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347Free PMC Article
Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Cutaneous sebaceous carcinoma.
Wu A, Rajak SN, Huilgol SC, James C, Selva D
Australas J Dermatol 2020 Aug;61(3):e283-e292. Epub 2020 Jan 19 doi: 10.1111/ajd.13234. PMID: 31956994
Guidelines of care for the management of cutaneous squamous cell carcinoma.
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Therapy

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 study): an open-label, nonrandomized, multicenter, phase II trial.
Hughes BGM, Munoz-Couselo E, Mortier L, Bratland Å, Gutzmer R, Roshdy O, González Mendoza R, Schachter J, Arance A, Grange F, Meyer N, Joshi A, Billan S, Zhang P, Gumuscu B, Swaby RF, Grob JJ
Ann Oncol 2021 Oct;32(10):1276-1285. Epub 2021 Jul 20 doi: 10.1016/j.annonc.2021.07.008. PMID: 34293460
Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial.
Sacco AG, Chen R, Worden FP, Wong DJL, Adkins D, Swiecicki P, Chai-Ho W, Oppelt P, Ghosh D, Bykowski J, Molinolo A, Pittman E, Estrada MV, Gold K, Daniels G, Lippman SM, Natsuhara A, Messer K, Cohen EEW
Lancet Oncol 2021 Jun;22(6):883-892. Epub 2021 May 11 doi: 10.1016/S1470-2045(21)00136-4. PMID: 33989559
Guidelines of care for the management of cutaneous squamous cell carcinoma.
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Prognosis

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review.
Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347Free PMC Article
Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Epidemiology of advanced cutaneous squamous cell carcinoma.
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.
Tam S, Gross ND
Curr Oncol Rep 2019 Jul 29;21(9):82. doi: 10.1007/s11912-019-0831-1. PMID: 31359288

Clinical prediction guides

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Reactive cutaneous capillary endothelial proliferation predicted the efficacy of camrelizumab in patients with recurrent/metastatic head and neck squamous cell carcinoma.
Ding Q, Liu Y, Ju H, Song H, Xiao Y, Liu X, Ren G, Wei D
Med Oral Patol Oral Cir Bucal 2023 Nov 1;28(6):e525-e529. doi: 10.4317/medoral.25919. PMID: 37330963Free PMC Article
Immunotherapy in advanced cutaneous squamous cell carcinoma: Sydney west cancer network experience.
Hasmat S, Howle JR, Carlino MS, Sundaresan P, Veness MJ
ANZ J Surg 2023 Jan;93(1-2):235-241. Epub 2022 Dec 25 doi: 10.1111/ans.18219. PMID: 36567642
Epidemiology and treatment outcomes of cutaneous squamous cell carcinoma extending to the temporal bone.
Schachtel MJC, Gandhi M, Bowman JJ, Porceddu SV, Panizza BJ
Head Neck 2022 Dec;44(12):2727-2743. Epub 2022 Sep 9 doi: 10.1002/hed.27185. PMID: 36082824Free PMC Article
LRIG and cancer prognosis.
Lindquist D, Kvarnbrink S, Henriksson R, Hedman H
Acta Oncol 2014 Sep;53(9):1135-42. Epub 2014 Sep 2 doi: 10.3109/0284186X.2014.953258. PMID: 25180912Free PMC Article

Recent systematic reviews

Superficial versus total parotidectomy for metastatic cutaneous squamous cell carcinoma and melanoma of the head and neck: a systematic review.
Leong WS, Gowda S, Jackson R, Chabrillac E, Edafe O
J Laryngol Otol 2023 Jun;137(6):592-598. Epub 2022 Aug 1 doi: 10.1017/S0022215122001724. PMID: 35912693
Squamous Cell Carcinoma With Bone Invasion: A Systematic Review and Pooled Survival Analysis.
Russell E, Udkoff J, Knackstedt T
Dermatol Surg 2022 Oct 1;48(10):1025-1028. Epub 2022 Jul 19 doi: 10.1097/DSS.0000000000003553. PMID: 35862674
Sentinel lymph node biopsy in high-risk cutaneous squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.
Costantino A, Canali L, Festa BM, Spriano G, Mercante G, De Virgilio A
Head Neck 2022 Oct;44(10):2288-2300. Epub 2022 Jun 17 doi: 10.1002/hed.27121. PMID: 35713173
The controversial role of electrochemotherapy in head and neck cancer: a systematic review of the literature.
Lenzi R, Muscatello L, Saibene AM, Felisati G, Pipolo C
Eur Arch Otorhinolaryngol 2017 Jun;274(6):2389-2394. Epub 2017 Feb 24 doi: 10.1007/s00405-017-4490-2. PMID: 28236011
Utility of head and neck cutaneous squamous cell carcinoma sentinel node biopsy: a systematic review.
Ahmed MM, Moore BA, Schmalbach CE
Otolaryngol Head Neck Surg 2014 Feb;150(2):180-7. Epub 2013 Nov 7 doi: 10.1177/0194599813511949. PMID: 24201060

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