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Erythroleukemia

MedGen UID:
1614281
•Concept ID:
C4520840
•
Neoplastic Process
Synonyms: erythroleukemia; Erythroleukemia (Erythroid/Myeloid); Erythroleukemia, Erythroid/Myeloid
 
Monarch Initiative: MONDO:0859598

Definition

Acute erythroid leukemia characterised by the presence of at least 50% erythroid precursors and at least 20% myeloblasts in the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythroleukemia

Professional guidelines

PubMed

Erythroleukemia-historical perspectives and recent advances in diagnosis and management.
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Acute erythroleukemia: diagnosis and management.
Santos FP, Bueso-Ramos CE, Ravandi F
Expert Rev Hematol 2010 Dec;3(6):705-18. doi: 10.1586/ehm.10.62. PMID: 21091147
Review: erythroleukemia: clinical course and management.
Masood A, Holkova B, Chanan-Khan A
Clin Adv Hematol Oncol 2010 Apr;8(4):288-90. PMID: 20505652

Recent clinical studies

Etiology

Erythroleukemia: an Update.
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Revisiting erythroleukemia.
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
Vardiman J, Reichard K
Am J Clin Pathol 2015 Jul;144(1):29-43. doi: 10.1309/AJCP58RSMFRHLHHH. PMID: 26071460
The history of myeloproliferative disorders: before and after Dameshek.
Tefferi A
Leukemia 2008 Jan;22(1):3-13. Epub 2007 Sep 20 doi: 10.1038/sj.leu.2404946. PMID: 17882283
CD36: a multiligand molecule.
Ge Y, Elghetany MT
Lab Hematol 2005;11(1):31-7. doi: 10.1532/LH96.04056. PMID: 15790550

Diagnosis

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.
Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Erythroleukemia: an Update.
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Pure erythroid leukemia.
Wang W, Wang SA, Medeiros LJ, Khoury JD
Am J Hematol 2017 Mar;92(3):292-296. Epub 2017 Feb 3 doi: 10.1002/ajh.24626. PMID: 28006859
Revisiting erythroleukemia.
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Regulation of the MIR155 host gene in physiological and pathological processes.
Elton TS, Selemon H, Elton SM, Parinandi NL
Gene 2013 Dec 10;532(1):1-12. Epub 2012 Dec 14 doi: 10.1016/j.gene.2012.12.009. PMID: 23246696

Therapy

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.
Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Development of a curative treatment within the AML-BFM studies.
Creutzig U, Zimmermann M, Dworzak MN, Ritter J, Schellong G, Reinhardt D
Klin Padiatr 2013 May;225 Suppl 1:S79-86. Epub 2013 May 22 doi: 10.1055/s-0033-1337968. PMID: 23700063
Discovery and development of SAHA as an anticancer agent.
Marks PA
Oncogene 2007 Feb 26;26(9):1351-6. doi: 10.1038/sj.onc.1210204. PMID: 17322921
From discovery to the coming generation of histone deacetylase inhibitors.
Yoshida M, Matsuyama A, Komatsu Y, Nishino N
Curr Med Chem 2003 Nov;10(22):2351-8. doi: 10.2174/0929867033456602. PMID: 14529478
The antitumor effects of interferon.
Gresser I
Med Oncol Tumor Pharmacother 1986;3(3-4):223-30. doi: 10.1007/BF02934998. PMID: 2433551

Prognosis

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.
Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Erythroleukemia: an Update.
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Erythroleukemia-historical perspectives and recent advances in diagnosis and management.
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Revisiting erythroleukemia.
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Acute erythroid leukemia.
Zuo Z, Polski JM, Kasyan A, Medeiros LJ
Arch Pathol Lab Med 2010 Sep;134(9):1261-70. doi: 10.5858/2009-0350-RA.1. PMID: 20807044

Clinical prediction guides

GAPDH is involved in the heme-maturation of myoglobin and hemoglobin.
Tupta B, Stuehr E, Sumi MP, Sweeny EA, Smith B, Stuehr DJ, Ghosh A
FASEB J 2022 Feb;36(2):e22099. doi: 10.1096/fj.202101237RR. PMID: 34972240Free PMC Article
Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole Derivatives.
Al-Jaidi BA, Telfah ST, Bardaweel SK, Deb PK, Borah P, Venugopala KN, Bataineh YA, Al Khames Aga QA
Curr Drug Metab 2021;22(7):532-536. doi: 10.2174/1389200221666201217094602. PMID: 33334285
Confirming the recessive inheritance of PERP-related erythrokeratoderma.
Patel N, Alkeraye S, Alobeid E, Alshidi T, Helaby R, Abdulwahab F, Shamseldin HE, Alkuraya FS
Clin Genet 2020 Apr;97(4):661-665. Epub 2020 Jan 12 doi: 10.1111/cge.13699. PMID: 31898316
Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
Vardiman J, Reichard K
Am J Clin Pathol 2015 Jul;144(1):29-43. doi: 10.1309/AJCP58RSMFRHLHHH. PMID: 26071460
Transcription factor GATA-1 and erythroid development.
Simon MC
Proc Soc Exp Biol Med 1993 Feb;202(2):115-21. doi: 10.3181/00379727-202-43519a. PMID: 8424101

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