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Adult Erythroleukemia

MedGen UID:
389533
•Concept ID:
C2347748
•
Neoplastic Process

Definition

An erythroleukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Erythroleukemia

Professional guidelines

PubMed

Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases.
Reichard KK, Tefferi A, Abdelmagid M, Orazi A, Alexandres C, Haack J, Greipp PT
Blood Cancer J 2022 Nov 2;12(11):147. doi: 10.1038/s41408-022-00746-x. PMID: 36323674Free PMC Article
Erythroleukemia: a review of 15 cases meeting 1985 FAB criteria and survey of the literature.
Atkinson J, Hrisinko MA, Weil SC
Blood Rev 1992 Dec;6(4):204-14. doi: 10.1016/0268-960x(92)90016-j. PMID: 1486289
Treatment of acute leukaemia in adults.
Wiernik PH
Clin Haematol 1978 Jun;7(2):259-73. doi: 10.1016/s0308-2261(78)80005-8. PMID: 354832

Recent clinical studies

Etiology

Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Diagnosis and characterization of acute erythroleukemia subsets by determining the percentages of myeloblasts and proerythroblasts in 69 cases.
Kowal-Vern A, Mazzella FM, Cotelingam JD, Shrit MA, Rector JT, Schumacher HR
Am J Hematol 2000 Sep;65(1):5-13. doi: 10.1002/1096-8652(200009)65:1<5::aid-ajh2>3.0.co;2-u. PMID: 10936857
Schistocytes in erythroleukemia.
Atkins JN, Muss HB
Am J Med Sci 1985 Mar;289(3):110-3. doi: 10.1097/00000441-198503000-00004. PMID: 3856384
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia.
Takeda J, Yoshida K, Nakagawa MM, Nannya Y, Yoda A, Saiki R, Ochi Y, Zhao L, Okuda R, Qi X, Mori T, Kon A, Chiba K, Tanaka H, Shiraishi Y, Kuo MC, Kerr CM, Nagata Y, Morishita D, Hiramoto N, Hangaishi A, Nakazawa H, Ishiyama K, Miyano S, Chiba S, Miyazaki Y, Kitano T, Usuki K, Sezaki N, Tsurumi H, Miyawaki S, Maciejewski JP, Ishikawa T, Ohyashiki K, Ganser A, Heuser M, Thol F, Shih LY, Takaori-Kondo A, Makishima H, Ogawa S
Blood Cancer Discov 2022 Sep 6;3(5):410-427. doi: 10.1158/2643-3230.BCD-21-0192. PMID: 35839275Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Acute Erythroleukemias, Acute Megakaryoblastic Leukemias, and Reactive Mimics: A Guide to a Number of Perplexing Entities.
Wang SA, Hasserjian RP
Am J Clin Pathol 2015 Jul;144(1):44-60. doi: 10.1309/AJCPRKYAT6EZQHC7. PMID: 26071461
Erythroid cell differentiation.
Forget BG, Glass J, Housman D
Hamatol Bluttransfus 1976;19:109-24. doi: 10.1007/978-3-642-87524-3_12. PMID: 1070457
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Therapy

Iron chelation rescues hemolytic anemia and skin photosensitivity in congenital erythropoietic porphyria.
Blouin JM, Ged C, Lalanne M, Lamrissi-Garcia I, Morice-Picard F, Costet P, Daher R, Moreau-Gaudry F, Bedel A, Puy H, Gouya L, Karim Z, Richard E
Blood 2020 Nov 19;136(21):2457-2468. doi: 10.1182/blood.2020006037. PMID: 32678895
Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity.
Briot T, Roger E, Bou Haidar N, Bejaud J, Lautram N, Guillet C, Thépot S, Legeay S, Lagarce F
Int J Nanomedicine 2019;14:2091-2102. Epub 2019 Mar 26 doi: 10.2147/IJN.S190482. PMID: 30988610Free PMC Article
Acute erythroleukemia, M6b.
Mazzella FM, Schumacher HR
Arch Pathol Lab Med 2000 Feb;124(2):330-1. doi: 10.5858/2000-124-0330-AEM. PMID: 10656753
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053
Hodgkin's disease and acute leukemia. Report of eight cases and review of the literature.
Rosner F, Grünwald H
Am J Med 1975 Mar;58(3):339-53. doi: 10.1016/0002-9343(75)90600-2. PMID: 1090158

Prognosis

Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia.
Takeda J, Yoshida K, Nakagawa MM, Nannya Y, Yoda A, Saiki R, Ochi Y, Zhao L, Okuda R, Qi X, Mori T, Kon A, Chiba K, Tanaka H, Shiraishi Y, Kuo MC, Kerr CM, Nagata Y, Morishita D, Hiramoto N, Hangaishi A, Nakazawa H, Ishiyama K, Miyano S, Chiba S, Miyazaki Y, Kitano T, Usuki K, Sezaki N, Tsurumi H, Miyawaki S, Maciejewski JP, Ishikawa T, Ohyashiki K, Ganser A, Heuser M, Thol F, Shih LY, Takaori-Kondo A, Makishima H, Ogawa S
Blood Cancer Discov 2022 Sep 6;3(5):410-427. doi: 10.1158/2643-3230.BCD-21-0192. PMID: 35839275Free PMC Article
Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity.
Briot T, Roger E, Bou Haidar N, Bejaud J, Lautram N, Guillet C, Thépot S, Legeay S, Lagarce F
Int J Nanomedicine 2019;14:2091-2102. Epub 2019 Mar 26 doi: 10.2147/IJN.S190482. PMID: 30988610Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Erythroleukemia: a need for a new definition.
Park S, Picard F, Dreyfus F
Leukemia 2002 Aug;16(8):1399-401. doi: 10.1038/sj.leu.2402549. PMID: 12145675
Erythroid cell differentiation.
Forget BG, Glass J, Housman D
Hamatol Bluttransfus 1976;19:109-24. doi: 10.1007/978-3-642-87524-3_12. PMID: 1070457

Clinical prediction guides

Confirming the recessive inheritance of PERP-related erythrokeratoderma.
Patel N, Alkeraye S, Alobeid E, Alshidi T, Helaby R, Abdulwahab F, Shamseldin HE, Alkuraya FS
Clin Genet 2020 Apr;97(4):661-665. Epub 2020 Jan 12 doi: 10.1111/cge.13699. PMID: 31898316
Incidence and geographic distribution of adult acute leukemia in the state of Georgia.
El Rassi F, Ward KC, Flowers CR, Heffner LT, Waller EK, Winton EF, Vaughn J, Hill BG, Langston A, Nooka A, Arellano M, Khoury HJ
South Med J 2014 Aug;107(8):497-500. doi: 10.14423/SMJ.0000000000000146. PMID: 25084186
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Transcription factor GATA-1 and erythroid development.
Simon MC
Proc Soc Exp Biol Med 1993 Feb;202(2):115-21. doi: 10.3181/00379727-202-43519a. PMID: 8424101
Erythroid cell differentiation.
Forget BG, Glass J, Housman D
Hamatol Bluttransfus 1976;19:109-24. doi: 10.1007/978-3-642-87524-3_12. PMID: 1070457

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