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Elevated creatine kinase after exercise

MedGen UID:
870262
•Concept ID:
C4024700
•
Finding
Synonyms: Elevated CK after exercise; Elevated CPK after exercise; Elevated creatine phosphokinase after exercise; Elevated phospho-CK after exercise; Elevated phospho-creatine kinase after exercise; Increased CK after exercise; Increased creatine kinase after exercise; Increased creatine phosphokinase after exercise; Increased phospho-CK after exercise; Increased phospho-creatine kinase after exercise
 
HPO: HP:0008331

Professional guidelines

PubMed

Elevation of serum creatine phosphokinase during growth hormone treatment in patients with multiple pituitary hormone deficiency.
Momoi T, Yamanaka C, Tanaka R, Yoshida A, Okumura M, Yamakura S, Takasaki Y, Sasaki H, Kawai M
Eur J Pediatr 1995 Nov;154(11):886-9. doi: 10.1007/BF01957498. PMID: 8582399
A rapid diagnostic and treatment center for patients with chest pain in the emergency department.
Gibler WB, Runyon JP, Levy RC, Sayre MR, Kacich R, Hattemer CR, Hamilton C, Gerlach JW, Walsh RA
Ann Emerg Med 1995 Jan;25(1):1-8. doi: 10.1016/s0196-0644(95)70347-0. PMID: 7802357

Recent clinical studies

Etiology

Effects of pre-sleep protein supplementation on plasma markers of muscle damage and inflammatory cytokines resulting from sprint interval training in trained swimmers.
Wu C, Deng J, Gao C
J Int Soc Sports Nutr 2023 Dec;20(1):2244478. doi: 10.1080/15502783.2023.2244478. PMID: 37543952Free PMC Article
Side effects of whole-body electro-myo-stimulation.
Stöllberger C, Finsterer J
Wien Med Wochenschr 2019 May;169(7-8):173-180. Epub 2018 Aug 23 doi: 10.1007/s10354-018-0655-x. PMID: 30141113
Biomarkers of Cardiac Stress and Injury in Athletes: What Do They Mean?
Donnellan E, Phelan D
Curr Heart Fail Rep 2018 Apr;15(2):116-122. doi: 10.1007/s11897-018-0385-9. PMID: 29520707
Exertional rhabdomyolysis and acute kidney injury.
Patel DR, Gyamfi R, Torres A
Phys Sportsmed 2009 Apr;37(1):71-9. doi: 10.3810/psm.2009.04.1685. PMID: 20048490
Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training.
Abe T, Kearns CF, Sato Y
J Appl Physiol (1985) 2006 May;100(5):1460-6. Epub 2005 Dec 8 doi: 10.1152/japplphysiol.01267.2005. PMID: 16339340

Diagnosis

Exertional rhabdomyolysis and causes of elevation of creatine kinase.
Bäcker HC, Busko M, Krause FG, Exadaktylos AK, Klukowska-Roetzler J, Deml MC
Phys Sportsmed 2020 May;48(2):179-185. Epub 2019 Sep 30 doi: 10.1080/00913847.2019.1669410. PMID: 31532694
Kidney Injury and Repair Biomarkers in Marathon Runners.
Mansour SG, Verma G, Pata RW, Martin TG, Perazella MA, Parikh CR
Am J Kidney Dis 2017 Aug;70(2):252-261. Epub 2017 Mar 28 doi: 10.1053/j.ajkd.2017.01.045. PMID: 28363731Free PMC Article
Approach to asymptomatic creatine kinase elevation.
Moghadam-Kia S, Oddis CV, Aggarwal R
Cleve Clin J Med 2016 Jan;83(1):37-42. doi: 10.3949/ccjm.83a.14120. PMID: 26760521Free PMC Article
Inclusion body myositis.
Dimachkie MM, Barohn RJ
Semin Neurol 2012 Jul;32(3):237-45. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329197. PMID: 23117948Free PMC Article
Incidence and follow-up of inflammatory cardiac complications after smallpox vaccination.
Eckart RE, Love SS, Atwood JE, Arness MK, Cassimatis DC, Campbell CL, Boyd SY, Murphy JG, Swerdlow DL, Collins LC, Riddle JR, Tornberg DN, Grabenstein JD, Engler RJ; Department of Defense Smallpox Vaccination Clinical Evaluation Team
J Am Coll Cardiol 2004 Jul 7;44(1):201-5. doi: 10.1016/j.jacc.2004.05.004. PMID: 15234435

Therapy

Effects of pre-sleep protein supplementation on plasma markers of muscle damage and inflammatory cytokines resulting from sprint interval training in trained swimmers.
Wu C, Deng J, Gao C
J Int Soc Sports Nutr 2023 Dec;20(1):2244478. doi: 10.1080/15502783.2023.2244478. PMID: 37543952Free PMC Article
Exertional rhabdomyolysis and causes of elevation of creatine kinase.
Bäcker HC, Busko M, Krause FG, Exadaktylos AK, Klukowska-Roetzler J, Deml MC
Phys Sportsmed 2020 May;48(2):179-185. Epub 2019 Sep 30 doi: 10.1080/00913847.2019.1669410. PMID: 31532694
Side effects of whole-body electro-myo-stimulation.
Stöllberger C, Finsterer J
Wien Med Wochenschr 2019 May;169(7-8):173-180. Epub 2018 Aug 23 doi: 10.1007/s10354-018-0655-x. PMID: 30141113
Approach to asymptomatic creatine kinase elevation.
Moghadam-Kia S, Oddis CV, Aggarwal R
Cleve Clin J Med 2016 Jan;83(1):37-42. doi: 10.3949/ccjm.83a.14120. PMID: 26760521Free PMC Article
Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training.
Abe T, Kearns CF, Sato Y
J Appl Physiol (1985) 2006 May;100(5):1460-6. Epub 2005 Dec 8 doi: 10.1152/japplphysiol.01267.2005. PMID: 16339340

Prognosis

Well-Trained Elders Have Antioxidant Responses and an Equal Magnitude of EIMD as Young Adults.
Tékus E, Szénási NL, Szabó E, Heckel Z, Mintál T, Kőszegi T, Atlasz T, Gazdag Z, Váczi M, Wilhelm M
Int J Environ Res Public Health 2022 Jul 22;19(15) doi: 10.3390/ijerph19158889. PMID: 35897260Free PMC Article
Exertional rhabdomyolysis and causes of elevation of creatine kinase.
Bäcker HC, Busko M, Krause FG, Exadaktylos AK, Klukowska-Roetzler J, Deml MC
Phys Sportsmed 2020 May;48(2):179-185. Epub 2019 Sep 30 doi: 10.1080/00913847.2019.1669410. PMID: 31532694
Viral myositis in children.
Magee H, Goldman RD
Can Fam Physician 2017 May;63(5):365-368. PMID: 28500193Free PMC Article
Kidney Injury and Repair Biomarkers in Marathon Runners.
Mansour SG, Verma G, Pata RW, Martin TG, Perazella MA, Parikh CR
Am J Kidney Dis 2017 Aug;70(2):252-261. Epub 2017 Mar 28 doi: 10.1053/j.ajkd.2017.01.045. PMID: 28363731Free PMC Article
Exertional rhabdomyolysis and acute kidney injury.
Patel DR, Gyamfi R, Torres A
Phys Sportsmed 2009 Apr;37(1):71-9. doi: 10.3810/psm.2009.04.1685. PMID: 20048490

Clinical prediction guides

Effects of pre-sleep protein supplementation on plasma markers of muscle damage and inflammatory cytokines resulting from sprint interval training in trained swimmers.
Wu C, Deng J, Gao C
J Int Soc Sports Nutr 2023 Dec;20(1):2244478. doi: 10.1080/15502783.2023.2244478. PMID: 37543952Free PMC Article
Clinical, morphological and genetic characterization of Brody disease: an international study of 40 patients.
Molenaar JP, Verhoeven JI, Rodenburg RJ, Kamsteeg EJ, Erasmus CE, Vicart S, Behin A, Bassez G, Magot A, Péréon Y, Brandom BW, Guglielmi V, Vattemi G, Chevessier F, Mathieu J, Franques J, Suetterlin K, Hanna MG, Guyant-Marechal L, Snoeck MM, Roberts ME, Kuntzer T, Fernandez-Torron R, Martínez-Arroyo A, Seeger J, Kusters B, Treves S, van Engelen BG, Eymard B, Voermans NC, Sternberg D
Brain 2020 Feb 1;143(2):452-466. doi: 10.1093/brain/awz410. PMID: 32040565Free PMC Article
Exertional rhabdomyolysis and causes of elevation of creatine kinase.
Bäcker HC, Busko M, Krause FG, Exadaktylos AK, Klukowska-Roetzler J, Deml MC
Phys Sportsmed 2020 May;48(2):179-185. Epub 2019 Sep 30 doi: 10.1080/00913847.2019.1669410. PMID: 31532694
Fatigue associated with prolonged graded running.
Giandolini M, Vernillo G, Samozino P, Horvais N, Edwards WB, Morin JB, Millet GY
Eur J Appl Physiol 2016 Oct;116(10):1859-73. Epub 2016 Jul 25 doi: 10.1007/s00421-016-3437-4. PMID: 27456477
Exertional rhabdomyolysis and acute kidney injury.
Patel DR, Gyamfi R, Torres A
Phys Sportsmed 2009 Apr;37(1):71-9. doi: 10.3810/psm.2009.04.1685. PMID: 20048490

Recent systematic reviews

The Effect of Monophasic Oral Contraceptives on Muscle Strength and Markers of Recovery After Exercise-Induced Muscle Damage: A Systematic Review.
Glenner-Frandsen A, With C, Gunnarsson TP, Hostrup M
Sports Health 2023 May;15(3):318-327. Epub 2022 Sep 25 doi: 10.1177/19417381221121653. PMID: 36154748Free PMC Article

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