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Elevated creatine kinase after exercise

MedGen UID:
870262
•Concept ID:
C4024700
•
Finding
Synonyms: Elevated CK after exercise; Elevated CPK after exercise; Elevated creatine phosphokinase after exercise; Elevated phospho-CK after exercise; Elevated phospho-creatine kinase after exercise; Increased CK after exercise; Increased creatine kinase after exercise; Increased creatine phosphokinase after exercise; Increased phospho-CK after exercise; Increased phospho-creatine kinase after exercise
 
HPO: HP:0008331

Professional guidelines

PubMed

Elevation of serum creatine phosphokinase during growth hormone treatment in patients with multiple pituitary hormone deficiency.
Momoi T, Yamanaka C, Tanaka R, Yoshida A, Okumura M, Yamakura S, Takasaki Y, Sasaki H, Kawai M
Eur J Pediatr 1995 Nov;154(11):886-9. doi: 10.1007/BF01957498. PMID: 8582399
A rapid diagnostic and treatment center for patients with chest pain in the emergency department.
Gibler WB, Runyon JP, Levy RC, Sayre MR, Kacich R, Hattemer CR, Hamilton C, Gerlach JW, Walsh RA
Ann Emerg Med 1995 Jan;25(1):1-8. doi: 10.1016/s0196-0644(95)70347-0. PMID: 7802357

Recent clinical studies

Etiology

Temperature and creatine kinase changes during a 10d taper period in sprinters.
Korman P, Kusy K, Kantanista A, Straburzyńska-Lupa A, Zieliński J
Physiol Meas 2021 Dec 29;42(12) doi: 10.1088/1361-6579/ac3d76. PMID: 34823228
Side effects of whole-body electro-myo-stimulation.
Stöllberger C, Finsterer J
Wien Med Wochenschr 2019 May;169(7-8):173-180. Epub 2018 Aug 23 doi: 10.1007/s10354-018-0655-x. PMID: 30141113
Biomarkers of Cardiac Stress and Injury in Athletes: What Do They Mean?
Donnellan E, Phelan D
Curr Heart Fail Rep 2018 Apr;15(2):116-122. doi: 10.1007/s11897-018-0385-9. PMID: 29520707
Inclusion body myositis.
Dimachkie MM, Barohn RJ
Semin Neurol 2012 Jul;32(3):237-45. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329197. PMID: 23117948Free PMC Article
Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training.
Abe T, Kearns CF, Sato Y
J Appl Physiol (1985) 2006 May;100(5):1460-6. Epub 2005 Dec 8 doi: 10.1152/japplphysiol.01267.2005. PMID: 16339340

Diagnosis

Exertional and CrossFit-Induced Rhabdomyolysis.
Meyer M, Sundaram S, Schafhalter-Zoppoth I
Clin J Sport Med 2021 Sep 1;31(5):e290-e292. doi: 10.1097/01.jsm.0000790440.65466.21. PMID: 34472544
Exertional and CrossFit-Induced Rhabdomyolysis.
Meyer M, Sundaram S, Schafhalter-Zoppoth I
Clin J Sport Med 2018 Nov;28(6):e92-e94. doi: 10.1097/JSM.0000000000000480. PMID: 28727638
Viral myositis in children.
Magee H, Goldman RD
Can Fam Physician 2017 May;63(5):365-368. PMID: 28500193Free PMC Article
Approach to asymptomatic creatine kinase elevation.
Moghadam-Kia S, Oddis CV, Aggarwal R
Cleve Clin J Med 2016 Jan;83(1):37-42. doi: 10.3949/ccjm.83a.14120. PMID: 26760521Free PMC Article
Inclusion body myositis.
Dimachkie MM, Barohn RJ
Semin Neurol 2012 Jul;32(3):237-45. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329197. PMID: 23117948Free PMC Article

Therapy

Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP).
Katsiki N, Mikhailidis DP, Bajraktari G, Miserez AR, Cicero AFG, Bruckert E, Serban MC, Mirrakhimov E, Alnouri F, Reiner Ž, Paragh G, Sahebkar A, Banach M; International Lipid Expert Panel (ILEP)
Pharmacol Res 2020 May;155:104719. Epub 2020 Feb 19 doi: 10.1016/j.phrs.2020.104719. PMID: 32087236
Exertional rhabdomyolysis and causes of elevation of creatine kinase.
Bäcker HC, Busko M, Krause FG, Exadaktylos AK, Klukowska-Roetzler J, Deml MC
Phys Sportsmed 2020 May;48(2):179-185. Epub 2019 Sep 30 doi: 10.1080/00913847.2019.1669410. PMID: 31532694
Side effects of whole-body electro-myo-stimulation.
Stöllberger C, Finsterer J
Wien Med Wochenschr 2019 May;169(7-8):173-180. Epub 2018 Aug 23 doi: 10.1007/s10354-018-0655-x. PMID: 30141113
Approach to asymptomatic creatine kinase elevation.
Moghadam-Kia S, Oddis CV, Aggarwal R
Cleve Clin J Med 2016 Jan;83(1):37-42. doi: 10.3949/ccjm.83a.14120. PMID: 26760521Free PMC Article
Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training.
Abe T, Kearns CF, Sato Y
J Appl Physiol (1985) 2006 May;100(5):1460-6. Epub 2005 Dec 8 doi: 10.1152/japplphysiol.01267.2005. PMID: 16339340

Prognosis

Changes in Creatine Kinase and Hormones Over the Course of an American Football Season.
Stone JD, Kreutzer A, Mata JD, Nystrom MG, Jagim AR, Jones MT, Oliver JM
J Strength Cond Res 2019 Sep;33(9):2481-2487. doi: 10.1519/JSC.0000000000001920. PMID: 28394834
Viral myositis in children.
Magee H, Goldman RD
Can Fam Physician 2017 May;63(5):365-368. PMID: 28500193Free PMC Article
Inclusion body myositis.
Dimachkie MM, Barohn RJ
Semin Neurol 2012 Jul;32(3):237-45. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329197. PMID: 23117948Free PMC Article
Exertional rhabdomyolysis: a clinical review with a focus on genetic influences.
Landau ME, Kenney K, Deuster P, Campbell W
J Clin Neuromuscul Dis 2012 Mar;13(3):122-36. doi: 10.1097/CND.0b013e31822721ca. PMID: 22538307
The cytokine response to strenuous exercise.
Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H
Can J Physiol Pharmacol 1998 May;76(5):505-11. doi: 10.1139/cjpp-76-5-505. PMID: 9839076

Clinical prediction guides

Exertional rhabdomyolysis and causes of elevation of creatine kinase.
Bäcker HC, Busko M, Krause FG, Exadaktylos AK, Klukowska-Roetzler J, Deml MC
Phys Sportsmed 2020 May;48(2):179-185. Epub 2019 Sep 30 doi: 10.1080/00913847.2019.1669410. PMID: 31532694
Changes in Creatine Kinase and Hormones Over the Course of an American Football Season.
Stone JD, Kreutzer A, Mata JD, Nystrom MG, Jagim AR, Jones MT, Oliver JM
J Strength Cond Res 2019 Sep;33(9):2481-2487. doi: 10.1519/JSC.0000000000001920. PMID: 28394834
Fatigue associated with prolonged graded running.
Giandolini M, Vernillo G, Samozino P, Horvais N, Edwards WB, Morin JB, Millet GY
Eur J Appl Physiol 2016 Oct;116(10):1859-73. Epub 2016 Jul 25 doi: 10.1007/s00421-016-3437-4. PMID: 27456477
Exertional rhabdomyolysis and acute kidney injury.
Patel DR, Gyamfi R, Torres A
Phys Sportsmed 2009 Apr;37(1):71-9. doi: 10.3810/psm.2009.04.1685. PMID: 20048490
The cytokine response to strenuous exercise.
Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H
Can J Physiol Pharmacol 1998 May;76(5):505-11. doi: 10.1139/cjpp-76-5-505. PMID: 9839076

Recent systematic reviews

The Effect of Monophasic Oral Contraceptives on Muscle Strength and Markers of Recovery After Exercise-Induced Muscle Damage: A Systematic Review.
Glenner-Frandsen A, With C, Gunnarsson TP, Hostrup M
Sports Health 2023 May;15(3):318-327. Epub 2022 Sep 25 doi: 10.1177/19417381221121653. PMID: 36154748Free PMC Article

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